{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T03:14:14Z","timestamp":1752549254468,"version":"3.37.0"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T00:00:00Z","timestamp":1733097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Homozygous inheritance of the R<jats:sup>N<\/jats:sup> haplotype, characterized by the absence of the high frequency antigen Sec, as well as partial C and e antigens, is rare and is associated with potential for alloimmunization. Anti\u2010Sec has been reported to be associated with a risk of delayed hemolytic transfusion reaction and hemolytic disease of the fetus and newborn (HDFN).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We report the case of a 36\u2010year\u2010old pregnant woman with known sickle cell trait (SCT) and homozygous for the R<jats:sup>N<\/jats:sup> haplotype with anti\u2010Sec, anti\u2010c, and anti\u2010e. Morphological ultrasound identified dextro\u2010transposition of the great arteries in the fetus. Neonatal cardiac surgery was planned with cardiopulmonary bypass support. Due to the rarity of this genotype, there were no compatible donors in our registry. For this reason, in addition to two previously glycerolized maternal donations, the mother donated three units during pregnancy and one unit postpartum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>This case highlights the many complexities for the blood supplier pertaining to organizing blood donations during pregnancy, the risk of leukoreduction failure and jellification during the deglycerolization process of units from donors with rare blood carrying the SCT, as well as planning the rare\u2010blood inventory and managing expiry dates to provide transfusion support during delivery, neonatal surgery, and the postoperative period. This case also exemplifies the importance of a strong partnership between blood suppliers and medical teams.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.18087","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T06:39:14Z","timestamp":1733207954000},"page":"234-239","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Planning antepartum directed donations in preparation for neonatal cardiac surgery in the absence of compatible donors"],"prefix":"10.1111","volume":"65","author":[{"given":"Marc","family":"Bienz","sequence":"first","affiliation":[{"name":"Transfusion Medicine H\u00e9ma\u2010Qu\u00e9bec  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto  Toronto Ontario Canada"},{"name":"Division of Hematology, Department of Medicine McGill University  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Constanzo\u2010Yanez","sequence":"additional","affiliation":[{"name":"Transfusion Medicine H\u00e9ma\u2010Qu\u00e9bec  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3024-7170","authenticated-orcid":false,"given":"Nadia","family":"Baillargeon","sequence":"additional","affiliation":[{"name":"Transfusion Medicine H\u00e9ma\u2010Qu\u00e9bec  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8144-1443","authenticated-orcid":false,"given":"Gabriel Andr\u00e9","family":"Leiva\u2010Torres","sequence":"additional","affiliation":[{"name":"Transfusion Medicine H\u00e9ma\u2010Qu\u00e9bec  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e9lissa","family":"Boileau","sequence":"additional","affiliation":[{"name":"Department of Hematology\u2010Oncology H\u00f4pital Maisonneuve\u2010Rosemont  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Cloutier","sequence":"additional","affiliation":[{"name":"Transfusion Medicine H\u00e9ma\u2010Qu\u00e9bec  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey","family":"Laforce\u2010Lavoie","sequence":"additional","affiliation":[{"name":"Transfusion Medicine H\u00e9ma\u2010Qu\u00e9bec  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Robitaille","sequence":"additional","affiliation":[{"name":"Transfusion Medicine H\u00e9ma\u2010Qu\u00e9bec  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Division of Hematology and Oncology, Department of Pediatrics CHU Sainte\u2010Justine  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Pediatrics Universit\u00e9 de Montr\u00e9al  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,2]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"International Society of Blood Transfusion (ISBT).Red cell immunogenetics and blood group terminology. Blood Group Allele Tables. (ISBT 004) RHCE blood group alleles v6.2\u201031\u2010MAR\u20102022 Amsterdam (ISBT Central Office). updated 2022\u201003\u201031. Available from:https:\/\/www.isbtweb.org\/resource\/004rhce.html"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-415849-8.00006-5"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118493595.ch5"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1989.29990070185.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.14740\/jmc3479"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/140.suppl1.191"},{"volume-title":"National Standard of Canada CAN\/CSA\u2010Z902:20 Blood and blood components","year":"2020","key":"e_1_2_9_8_1"},{"key":"e_1_2_9_9_1","first-page":"72A","article-title":"2022 plenary, Oral, and poster abstract presentations","volume":"62","year":"2022","journal-title":"Transfusion"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.12348"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17021"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17077"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.21307\/immunohematology-2019-281"},{"volume-title":"Standards for blood banks and transfusion services","year":"2022","author":"(AABB) AftAoBB","key":"e_1_2_9_14_1"},{"key":"e_1_2_9_15_1","unstructured":"Audrey Laforce\u2010LavoieM\u2010JDG ConstanzoJ YanezNA LoiselleS RobitailleN MarcC.Supplement P\u2010BB\u201094: Sickle\u2010Cell Trait Donors: Can we process red blood cell products with the ACP 215? AABB annual meeting 2019; San Antonio: Transfusion.2019."},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1976.16677060246.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cryobiol.2024.104903"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.18087","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T04:14:20Z","timestamp":1739333660000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.18087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,2]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/trf.18087"],"URL":"https:\/\/doi.org\/10.1111\/trf.18087","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"type":"print","value":"0041-1132"},{"type":"electronic","value":"1537-2995"}],"subject":[],"published":{"date-parts":[[2024,12,2]]},"assertion":[{"value":"2024-08-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}