{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T09:40:01Z","timestamp":1739526001031,"version":"3.37.0"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,22]],"date-time":"2024-12-22T00:00:00Z","timestamp":1734825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Acute myocardial infarction (AMI) poses a significant global health burden, warranting meticulous management strategies, particularly in patients with concurrent anemia. Blood transfusion strategies play a pivotal role in optimizing oxygen delivery while minimizing transfusion\u2010related risks. Two contrasting approaches, liberal and restrictive transfusion strategies, have emerged, yet their comparative effectiveness remains uncertain due to conflicting evidence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a systematic review and meta\u2010analysis focusing on randomized controlled trials (RCTs) comparing liberal versus restrictive transfusion strategies in AMI patients with anemia (hemoglobin levels &lt;10\u2009g\/dL). Comprehensive searches were performed across electronic databases up to March 31, 2024. Data extraction, risk of bias assessment using Cochrane's RoB 2 tool, and meta\u2010analysis were conducted following methodology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 327 initially identified studies, four high\u2010quality RCTs met the inclusion criteria. These trials encompassed varied sample sizes and patient demographics. Meta\u2010analysis revealed no significant difference in 30\u2010day all\u2010cause mortality nor recurrent MI between liberal and restrictive transfusion strategies. However, combining these outcomes into a composite measure demonstrated a significant reduction favoring liberal transfusion (pooled odds ratio\u2009=\u20090.82; 95% confidence interval\u2009=\u20090.69\u20130.99).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>While liberal transfusion strategies show promise in reducing adverse outcomes, clinical decision\u2010making should be guided by individual patient factors and preferences. Personalized care remains paramount in determining the most appropriate transfusion approach for AMI patients with anemia. Further research is warranted to elucidate the optimal transfusion strategy in this population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.18110","type":"journal-article","created":{"date-parts":[[2024,12,22]],"date-time":"2024-12-22T18:39:14Z","timestamp":1734892754000},"page":"260-266","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative efficacy of liberal and restrictive blood transfusion strategies in anemic patients with acute myocardial infarction: A systematic review and meta\u2010analysis of randomized controlled trials"],"prefix":"10.1111","volume":"65","author":[{"given":"Chia Siang","family":"Kow","sequence":"first","affiliation":[{"name":"School of Pharmacy, IMU University  Kuala Lumpur Malaysia"},{"name":"School of Applied Sciences, University of Huddersfield  Huddersfield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dinesh Sangarran","family":"Ramachandram","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Monash University Malaysia  Sunway City Selangor Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed Shahzad","family":"Hasan","sequence":"additional","affiliation":[{"name":"School of Applied Sciences, University of Huddersfield  Huddersfield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3754-1690","authenticated-orcid":false,"given":"Kaeshaelya","family":"Thiruchelvam","sequence":"additional","affiliation":[{"name":"School of Pharmacy, IMU University  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,22]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_8_2_1","DOI":"10.1186\/s12872-017-0482-9"},{"key":"e_1_2_8_3_1","article-title":"Acute anemia and myocardial infarction","volume":"13","author":"Padda J","year":"2021","journal-title":"Cureus"},{"key":"e_1_2_8_4_1","article-title":"Restrictive versus liberal red blood cell transfusion strategies for people with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem cell support","volume":"1","author":"Estcourt LJ","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"doi-asserted-by":"publisher","key":"e_1_2_8_5_1","DOI":"10.1016\/j.hsr.2022.100059"},{"doi-asserted-by":"publisher","key":"e_1_2_8_6_1","DOI":"10.1136\/bmj.n71"},{"unstructured":"Cochrane Methods Bias.RoB 2: A Revised Cochrane Risk\u2010of\u2010Bias Tool for Randomized Trials.2023. Available from:https:\/\/methods.cochrane.org\/bias\/resources\/rob\u20102\u2010revised\u2010cochrane\u2010risk\u2010bias\u2010tool\u2010randomized\u2010trials","key":"e_1_2_8_7_1"},{"doi-asserted-by":"publisher","key":"e_1_2_8_8_1","DOI":"10.1016\/j.ahj.2013.03.001"},{"doi-asserted-by":"publisher","key":"e_1_2_8_9_1","DOI":"10.1016\/j.amjcard.2011.06.014"},{"doi-asserted-by":"publisher","key":"e_1_2_8_10_1","DOI":"10.1001\/jama.2021.0135"},{"doi-asserted-by":"publisher","key":"e_1_2_8_11_1","DOI":"10.1056\/NEJMoa2307983"},{"doi-asserted-by":"publisher","key":"e_1_2_8_12_1","DOI":"10.1016\/j.amjmed.2014.01.011"},{"doi-asserted-by":"publisher","key":"e_1_2_8_13_1","DOI":"10.2450\/BloodTransfus.427"},{"doi-asserted-by":"publisher","key":"e_1_2_8_14_1","DOI":"10.1161\/01.CIR.0000162477.70955.5F"},{"doi-asserted-by":"publisher","key":"e_1_2_8_15_1","DOI":"10.1007\/s00395-020-0799-x"},{"doi-asserted-by":"publisher","key":"e_1_2_8_16_1","DOI":"10.1056\/NEJMra1612789"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.18110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T08:56:21Z","timestamp":1739523381000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.18110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,22]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1111\/trf.18110"],"URL":"https:\/\/doi.org\/10.1111\/trf.18110","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"type":"print","value":"0041-1132"},{"type":"electronic","value":"1537-2995"}],"subject":[],"published":{"date-parts":[[2024,12,22]]},"assertion":[{"value":"2024-04-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}