{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T15:05:07Z","timestamp":1789657507490,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>As low titer group O whole blood (LTOWB) increases in popularity, blood centers are finding innovative ways of maintaining the supply. One potential way is collecting LTOWB from parous female donors without testing for HLA antibodies. This in silico simulation predicted the risk of an LTOWB unit containing an HLA antibody and the subsequent risk for an HLA\u2010incompatible transfusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An LTOWB blood bank with 1 million units was simulated consisting of male, nulliparous, and parous female donors. The proportion of each donor type was modeled after the sex distribution at US blood centers. The parity of female donors was calculated based on the average number of live births per female depending on her age. HLA\u2010alloimmunization risk was determined by her parity status. The HLA haplotypes of the simulated recipients were derived from the 100 most common HLA haplotypes in the US National Marrow Registry Program database. The proportion of different race\/ethnic groups in the US was used to simulate 100,000 LTOWB recipients to whom between 1 and 10 units were administered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, the risk of an LTOWB unit containing at least one HLA antibody was 12.2% and the rate of receiving an HLA\u2010incompatible unit was 21.3%. The risk of receiving an HLA\u2010incompatible unit rose from 4.8% after receipt of one unit to 36.5% after 10 units.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Blood collectors and hospitals should evaluate the potential TRALI risk against the benefit of a potentially expanded inventory of LTOWB before collecting plasma\u2010containing products from non\u2010HLA\u2010tested parous female donors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.18141","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T13:24:57Z","timestamp":1738761897000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["An in silico simulation of the frequency of administering\n                    <scp>HLA<\/scp>\n                    \u2010incompatible low titer group O whole blood units when the donor pool includes unscreened female donors"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6740-2758","authenticated-orcid":false,"given":"Mark H.","family":"Yazer","sequence":"first","affiliation":[{"name":"Department of Pathology University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Ngamsuntikul","sequence":"additional","affiliation":[{"name":"South Texas Blood &amp; Tissue  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7210-1909","authenticated-orcid":false,"given":"Manish","family":"Gandhi","sequence":"additional","affiliation":[{"name":"Division of Transfusion Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8823-2719","authenticated-orcid":false,"given":"Torunn","family":"Apelseth","sequence":"additional","affiliation":[{"name":"Norwegian Center for Blood Preparedness, Department of Immunology and Transfusion Medicine Haukeland University Hospital  Bergen Norway"},{"name":"Institute of Clinical Science, Faculty of Medicine University of Bergen  Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audra","family":"Taylor","sequence":"additional","affiliation":[{"name":"South Texas Blood &amp; Tissue  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6850-7495","authenticated-orcid":false,"given":"Jansen N.","family":"Seheult","sequence":"additional","affiliation":[{"name":"Division of Hematopathology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0041-1132.2004.04347.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000159849.94750.51"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15311"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2018.1.585"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0000000000000607"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1175387"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13459"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2021.100926"},{"key":"e_1_2_7_10_1","first-page":"465","article-title":"Human neutrophil antigen 3 genotype impacts neutrophil\u2010mediated endothelial cell cytotoxicity in a two\u2010event model of TRALI","volume":"20","author":"Chiaretti S","year":"2022","journal-title":"Blood Transfus"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-286146"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01102.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02715.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02969.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2012.01596.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02652.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15387"},{"key":"e_1_2_7_18_1","unstructured":"AABB.Board of Directors. 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