{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:30:26Z","timestamp":1790375426151,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN 75N92019D00032"],"award-info":[{"award-number":["HHSN 75N92019D00032"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN 75N92019D00033"],"award-info":[{"award-number":["HHSN 75N92019D00033"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Despite data supporting the safety of SARS\u2010CoV\u20102 vaccination, concerns regarding the receipt of blood products from donors previously infected or vaccinated against SARS\u2010CoV\u20102 persist. We assessed whether transfusions of plasma or platelet products from donors with prior SARS\u2010CoV\u20102 infection or vaccination were associated with adverse outcomes in patients without COVID\u201019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We linked donor SARS\u2010CoV\u20102 spike and nucleocapsid antibody data and vaccination history to blood products transfused between June 1, 2020 and March 31, 2022. We used logistic regression, adjusting for demographics and comorbidities, to calculate odds ratios and 95% confidence intervals (CI) for posttransfusion thrombosis, increased respiratory requirement, and hospital mortality. Outcomes were assessed as per transfused unit from previously infected or vaccinated donors compared to units from uninfected or unvaccinated donors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 8715 hospitalizations of 7773 transfusion recipients linked to donor SARS\u2010CoV\u20102 antibody data, there were 251 thromboses, 700 hospitalizations with increased respiratory requirements, and 1443 deaths. Among 15,167 transfused plasma units, 4993 and 1106 were from vaccinated donors and previously infected donors, respectively. Among 19,295 transfused platelet units, 8530 and 1368 were from vaccinated and previously infected donors, respectively. There were no associations between the transfusion of blood products from vaccinated or previously infected donors and thrombosis, increased respiratory requirements, or hospital mortality (all CI including 1). Nor were there associations between the receipt of blood products from recently infected or vaccinated donors or high SARS\u2010CoV\u20102 antibody titers and adverse outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Donor SARS\u2010Cov\u20102 infection and vaccination were not associated with adverse patient outcomes and do not need to be considered in blood allocation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.18159","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T18:50:53Z","timestamp":1741719053000},"page":"485-495","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Blood donor <scp>SARS<\/scp>\u2010<scp>CoV<\/scp>\u20102 infection or vaccination and adverse outcomes in plasma and platelet transfusion recipients"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1063-6155","authenticated-orcid":false,"given":"Nareg H.","family":"Roubinian","sequence":"first","affiliation":[{"name":"Kaiser Permanente Northern California Division of Research  Pleasanton California USA"},{"name":"Vitalant Research Institute  San Francisco California USA"},{"name":"Department of Laboratory Medicine, UCSF  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0859-6828","authenticated-orcid":false,"given":"John","family":"Greene","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Northern California Division of Research  Pleasanton California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9008-9154","authenticated-orcid":false,"given":"Bryan R.","family":"Spencer","sequence":"additional","affiliation":[{"name":"American Red Cross, 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6251-366X","authenticated-orcid":false,"given":"Brian","family":"Custer","sequence":"additional","affiliation":[{"name":"Vitalant Research Institute  San Francisco California USA"},{"name":"Department of Laboratory Medicine, UCSF  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Kleinman","sequence":"additional","affiliation":[{"name":"University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent X.","family":"Liu","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Northern California Division of Research  Pleasanton California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0526-2088","authenticated-orcid":false,"given":"Philip 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