{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:25:40Z","timestamp":1791383140771,"version":"4.3.3"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T00:00:00Z","timestamp":1740960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000102","name":"Health Resources and Services Administration","doi-asserted-by":"publisher","award":["H30MC2404"],"award-info":[{"award-number":["H30MC2404"]}],"id":[{"id":"10.13039\/100000102","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction\/Background<\/jats:title><jats:p>Platelet membrane glycoproteins (GPs) serve several functions, the most significant of which is their role in primary hemostasis. Among these, GP IIb\/IIIa is the primary fibrinogen receptor and is essential for platelet aggregation. Its deficiency or dysfunction impairs platelet aggregation, leading to Glanzmann thrombasthenia, a rare autosomal recessive bleeding disorder. In contrast, platelet GP IV (CD36) has a limited role in primary hemostasis. While also rare, CD36 deficiency has a disproportionately higher prevalence in individuals of East Asian, African, and Arabian descent.<\/jats:p><jats:p>Patients with platelet GP deficiencies can develop antibodies against the missing GPs, leading to immune\u2010mediated platelet transfusion refractoriness (PTR). Consequently, they are unresponsive to platelet transfusions when mostly needed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Presentation<\/jats:title><jats:p>Here we present the case of an Egyptian male with a lifelong history of an incompletely characterized bleeding disorder who presented for pre\u2010surgical evaluation. We diagnosed the patient with Type I Glanzmann thrombasthenia. Further evaluation revealed anti\u2010CD36 antibodies, leading to the discovery of a concurrent platelet CD36 deficiency. The dual GP deficiency significantly complicated his management, as finding crossmatch\u2010compatible platelets was challenging due to the rarity of CD36\u2010deficient blood donors in the United States.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion\/Conclusion<\/jats:title><jats:p>Awareness of coexisting platelet disorders and their ramifications is limited, mostly because these are stochastically rare (~1 in 100 million for the present case). This case highlights the importance of thoroughly evaluating platelet glycoprotein deficiencies, particularly in individuals with severe bleeding disorders and from ethnic backgrounds with a predisposition to specific platelet disorders. Such an approach can prevent future platelet antibody formation or reduce bleeding risk with pre\u2010existing antibodies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.18176","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T23:51:14Z","timestamp":1741737074000},"page":"767-772","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Management challenge of a rare concomitant platelet glycoprotein <scp>IV<\/scp>\/<scp>CD36<\/scp> and <scp>IIb<\/scp>\/<scp>IIIa<\/scp> deficiencies: Case illustration"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7050-0020","authenticated-orcid":false,"given":"Tro","family":"Sekayan","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Hematology\/Oncology University of California San Diego  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth S.","family":"Allen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Division of Laboratory and Genomic Medicine University of California San Diego  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Kopko","sequence":"additional","affiliation":[{"name":"Department of Pathology, Division of Laboratory and Genomic Medicine University of California San Diego  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9101-9326","authenticated-orcid":false,"given":"Laura D.","family":"Stephens","sequence":"additional","affiliation":[{"name":"Department of Pathology, Division of Laboratory and Genomic Medicine University of California San Diego  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pathology, Division of Laboratory and Genomic Medicine University of California San Diego  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9553-9081","authenticated-orcid":false,"given":"Brian R.","family":"Curtis","sequence":"additional","affiliation":[{"name":"Platelet and Neutrophil Immunology and Hematology Genetics Labs, Versiti  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mia J.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Platelet and Neutrophil Immunology and Hematology Genetics Labs, Versiti  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Trapp\u2010Stamborski","sequence":"additional","affiliation":[{"name":"Platelet and Neutrophil Immunology and Hematology Genetics Labs, Versiti  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"von Drygalski","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology\/Oncology University of California San Diego  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2023.282836"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-1768935"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/hematology.2020000137"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.214239"},{"key":"e_1_2_11_6_1","first-page":"685","article-title":"in vivo\u201d disorder of platelet adhesiveness in Willebrand's disease and Glanzmann's thrombasthenias. Trial interpretation","volume":"2","author":"Caen J","year":"1962","journal-title":"Nouv Rev Fr Hematol"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1974.tb06660.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/255720a0"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V101.3.929"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113548"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108805"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V75.7.1383.1383"},{"key":"e_1_2_11_13_1","volume-title":"Prescribing Information (coagulation factor VIIa [recombinant])","author":"NovoSeven RT","year":"2020"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-58491-z"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/labmed\/lmz091"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V83.2.392.392"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10122356"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.781294"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04662-6"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1989.tb00826.x"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02749.x"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1995.35996029165.x"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V82.3.820.820"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2002.00176.x"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.21037\/aob-21-36"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2015.30"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.18176","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T17:49:45Z","timestamp":1744912185000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.18176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,3]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1111\/trf.18176"],"URL":"https:\/\/doi.org\/10.1111\/trf.18176","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,3]]},"assertion":[{"value":"2025-01-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}