{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T15:04:39Z","timestamp":1789657479005,"version":"4.0.1"},"reference-count":37,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The Los Angeles Development and Rapid Operationalization of Prehospital Blood (LA\u2010DROP) pilot will protocolize prehospital administration of low titer O\u2010positive whole blood (LTO\u2009+\u2009WB) to patients with hemorrhagic shock in Los Angeles County (LAC). We sought to quantify the risk of death from hemolytic disease of the fetus and newborn (HDFN) associated with RhD\u2010negative alloimmunization in females of childbearing potential (FCPs) as a result of LA\u2010DROP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design and Methods<\/jats:title>\n                    <jats:p>Retrospective data from LAC EMS databases were used in combination with estimates from published literature to assign probability distributions to each event in the sequence required for a transfusion of LTO\u2009+\u2009WB to result in a death from HDFN. Markov chain Monte Carlo simulation was used to derive risk estimates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We estimated that the proposed prehospital transfusion strategy would result on average in one death from HDFN for every 10,000 transfusions in the overall population (95% confidence interval [CI] 6000\u201325,000) and for every 1800 transfusions in FCPs (95% CI 1000\u20134300). Based on the projected annual volume of transfusions under LA\u2010DROP, this would result in one death due to HDFN approximately every 26\u2009years (95% CI 15\u201364).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The estimated per\u2010transfusion risk of HDFN is similar to previously published work from other populations. The estimated frequency of deaths from HDFN associated with LA\u2010DROP is lower than some previously published calculations, likely because of narrower eligibility criteria for transfusion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.18184","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T01:29:41Z","timestamp":1741742981000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A prehospital protocol for transfusion of low\u2010titer O\u2010positive whole blood in patients with hemorrhagic shock in Los Angeles County: Modeling the risk of hemolytic disease of the fetus and newborn"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8490-7950","authenticated-orcid":false,"given":"Kelsey","family":"Wilhelm","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine Harbor\u2010UCLA Medical Center &amp; The Lundquist Institute  Torrance California USA"},{"name":"David Geffen School of Medicine at UCLA  Los Angeles California USA"},{"name":"City of Compton Fire Department  Compton California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6361-6688","authenticated-orcid":false,"given":"Caroline","family":"Lauer","sequence":"additional","affiliation":[{"name":"David Geffen School of Medicine at UCLA  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0888-9732","authenticated-orcid":false,"given":"Rachel","family":"Rangwala","sequence":"additional","affiliation":[{"name":"David Geffen School of Medicine at UCLA  Los Angeles California USA"},{"name":"Department of Pathology and Laboratory Medicine Harbor\u2010UCLA Medical Center  Torrance California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanin","family":"Zadeh","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Harbor\u2010UCLA Medical Center  Torrance California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1721-0541","authenticated-orcid":false,"given":"Philip C.","family":"Spinella","sequence":"additional","affiliation":[{"name":"Department of Surgery and Critical Care Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Tolles","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Harbor\u2010UCLA Medical Center &amp; The Lundquist Institute  Torrance California USA"},{"name":"David Geffen School of Medicine at UCLA  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,1]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e31819d85fb"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000006244"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17746"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17787"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13249"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/16078454.2022.2161215"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17767"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17700"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/PHH.0000000000000745"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/10903127.2019.1588444"},{"key":"e_1_2_9_12_1","unstructured":"Los Angeles County EMS Agency Ref. 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