{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T15:05:08Z","timestamp":1789657508376,"version":"4.0.1"},"reference-count":29,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T00:00:00Z","timestamp":1742688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T00:00:00Z","timestamp":1742688000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The use of low\u2010titer O whole blood (LTOWB) for traumatic hemorrhage is growing. Most LTOWB for use in adults is RhD\u2010positive, which presents potential risks to females of childbearing potential (FCP); however, data on practice patterns are lacking. We sought to assess the use of LTOWB among FCPs compared to similarly aged males in facilities with documented LTOWB capabilities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We compared FCP (females 15\u201350\u2009years of age) to similarly aged males (or sex unclassified\/undocumented) who were included in the Trauma Quality Improvement Program database from 2020 to 2022. This database records transfusion volumes administered within the first 4\u2009h after admission and patient demographics. We compared LTOWB use among FCPs versus similarly aged males using descriptive, inferential, and multivariable statistics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were 79,298 that met inclusion for this analysis. There were 16,823 (21%) FCPs, of whom, 2759\/16,823 (16%) received any volume of LTOWB compared to 16,310\/62,475 (26%) of the males. Furthermore, among LTOWB recipients, the median (interquartile range) volume administered to FCPs was 1162\u2009mL (500\u20131000) compared to 1352\u2009mL (500\u20131000,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.003) for males. In our multivariable logistic regression analysis, males had a higher odds for the receipt of LTOWB compared to FCPs (odds ratio 1.76, 95% confidence interval 1.68\u20131.84) after adjusting for age, mechanism of injury, and composite injury severity score. These findings persisted on sensitivity testing.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Males were more likely than FCPs to receive LTOWB during trauma resuscitation in unadjusted and adjusted analyses. The reasons for such differences require elucidation in future prospective studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.18208","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T01:30:06Z","timestamp":1742779806000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A national database review of whole blood use among females of childbearing potential experiencing traumatic hemorrhage"],"prefix":"10.1111","volume":"65","author":[{"given":"James M.","family":"Makinen","sequence":"first","affiliation":[{"name":"Department of Anesthesiology University of Colorado School of Medicine  Aurora Colorado USA"},{"name":"Department of Emergency Medicine University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Douin","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Trauma Brooke Army Medical Center, JBSA Fort Sam Houston  San Antonio Texas USA"},{"name":"Department of Surgery Uniformed Services University of the Health Sciences  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan S.","family":"Hirshberg","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Maternal\u2010Fetal Medicine University of Colorado School of Medicine  Aurora Colorado USA"},{"name":"Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Whitney R.","family":"Jenson","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of GI, Trauma and Endocrine Surgery University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie M.","family":"Winkle","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology University of Colorado School of Medicine  Aurora Colorado USA"},{"name":"Department of Emergency Medicine University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6740-2758","authenticated-orcid":false,"given":"Mark H.","family":"Yazer","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven G.","family":"Schauer","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology University of Colorado School of Medicine  Aurora Colorado USA"},{"name":"Department of Emergency Medicine University of Colorado School of Medicine  Aurora Colorado USA"},{"name":"Center for Combat and Battlefield (COMBAT) Research University of Colorado School of Medicine  Aurora Colorado USA"},{"name":"US Army Medical Center of Excellence JBSA Fort Sam Houston  San Antonio Texas 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is time to reconsider the risks of transfusing RhD negative females of childbearing potential with RhD positive red blood cells in bleeding emergencies","volume":"59","author":"Yazer MH","year":"2019","journal-title":"Transfus Clin 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