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Current resuscitation approaches minimize crystalloids and emphasize plasma and other blood components to achieve a balanced transfusion as early as possible after injury. Owing to the nature of military operations, military medical systems must contend with great distances, degraded infrastructure, and harsh environments, as well as combat and humanitarian assistance and disaster relief (HADR) scenarios. These factors limit both patient movement and the ability to deliver blood products to the point of need. Current projections are that future military scenarios will have longer times to reach a medical treatment facility than experienced in recent conflicts, increasing the need for logistically efficient blood products. Freeze\u2010dried plasma (FDP) is rapidly available, easy to use, and shelf\u2010stable at room temperature, making it easier to deliver at the point of need in challenging military environments. For the past 30\u2009years, FDP has been available in only a few countries. Where it has been available, it has become the preferred plasma for austere or military expeditionary settings. Recently, a new FDP, OctaplasLG Powder, was approved in 17 countries worldwide and for emergency use by the Canadian and United States militaries. It is expected that FDP will soon become available to many more militaries. This review discusses the importance of plasma, reassesses the potential military uses of FDP across the range of military operations, and provides a brief discussion of OctaplasLG Powder.<\/jats:p>","DOI":"10.1111\/trf.18213","type":"journal-article","created":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T06:01:19Z","timestamp":1743832879000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Potential military applications for a new freeze\u2010dried plasma"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1324-4835","authenticated-orcid":false,"given":"Anthony E.","family":"Pusateri","sequence":"first","affiliation":[{"name":"Naval Medical Research Unit San Antonio Joint Base San Antonio\u2010Fort Sam Houston  San Antonio Texas USA"},{"name":"Department of Surgery Uniformed Services University of Health Sciences  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam J.","family":"Kishman","sequence":"additional","affiliation":[{"name":"Expeditionary and Trauma Medicine Naval Medical Research Unit San Antonio, Joint Base San Antonio\u2010Fort Sam Houston  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad Azlan Bin","family":"Ariffin","sequence":"additional","affiliation":[{"name":"Royal Medical and Dental Corps Hospital Angkatan Tentera Tuanku Mizan  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Watts","sequence":"additional","affiliation":[{"name":"Defence Science and Technology Laboratory  Salisbury UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emrys","family":"Kirkman","sequence":"additional","affiliation":[{"name":"Defence Science and Technology Laboratory  Salisbury UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1749-1726","authenticated-orcid":false,"given":"Richard B.","family":"Weiskopf","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan S.","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Combat Casualty Care Directorate Naval Medical Research Unit San Antonio, Joint Base San Antonio\u2010Fort Sam Houston  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandy J.","family":"Snyder","sequence":"additional","affiliation":[{"name":"Congressionally Directed Medical Research Programs  Fort Detrick Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Cardin","sequence":"additional","affiliation":[{"name":"United States Army Institute of Surgical Research Joint Base San Antonio\u2010Fort Sam Houston  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewell M.","family":"Hollis","sequence":"additional","affiliation":[{"name":"Naval Medical Center Portsmouth  Portsmouth Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Hegener","sequence":"additional","affiliation":[{"name":"Octapharma AG  Lachen Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ta.0000199961.02677.19"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e3182755dcc"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000000292"},{"key":"e_1_2_7_5_1","unstructured":"American College of Surgeons Trauma Quality Improvement Program.Massive transfusion in trauma guidelines [2024 May 22].2014Available from:https:\/\/www.facs.org\/-\/media\/files\/quality-programs\/trauma\/tqip\/transfusion_guildelines.ashx"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0000000000001025"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-023-04327-7"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15261"},{"key":"e_1_2_7_9_1","unstructured":"NHS.Dried blood plasma project to help save soldiers' lives launches. 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