{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T18:54:54Z","timestamp":1754160894444,"version":"3.41.2"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:00:00Z","timestamp":1743724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","award":["IN\u2010NL\u2010980\u20107034"],"award-info":[{"award-number":["IN\u2010NL\u2010980\u20107034"]}],"id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hepatitis Delta virus (HDV) requires co\u2010infection with hepatitis B virus (HBV) and increases the risk of hepatitis\u2010related morbidity and mortality compared to HBV mono\u2010infection. HBV\/HDV co\u2010infected patients will likely benefit from new HDV antiviral drugs, but reliable estimates of co\u2010infection rates are lacking due to limited HDV testing of HBV\u2010infected patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>First\u2010time blood and bone tissue donors in the Netherlands (2006\u20132023) with a newly diagnosed chronic HBV infection were retrospectively tested for HDV antibodies, and for HDV RNA if HDV antibodies were detected. HBV genotyping using phylogenetic analysis was performed to determine the most likely origin of HBV infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>HBV\u2010DNA was detected in 254\/758.081 (0.034%) first\u2010time donors in the Netherlands. HBsAg\u2010positive first\u2010time donors had a median age of 43\u2009years (IQR: 33\u201352), were predominantly male (67%), mostly first\u2010 or second\u2010generation migrants (76%) and HBV (sub)genotype strongly correlated with the country of birth. HDV testing was performed for 200 first\u2010time donors with chronic (HBsAg\u2010positive) HBV infection: 5 donors (2.5%) had HDV antibodies, and 1 donor (0.5%) also had detectable HDV RNA. None of the 17 donors with occult (HBsAg\u2010negative) HBV infection had experienced HDV infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Chronic HBV\/HDV co\u2010infection in first\u2010time donors in the Netherlands is extremely rare, affecting 0.00013% of all first\u2010time donors, and only 0.5% of HBsAg\u2010positive first\u2010time donors consisting predominantly of migrants from high(er) HDV\u2010endemic countries. Despite low HBV\/HDV co\u2010infection rates, a one\u2010time HDV reflex testing strategy for HBsAg\u2010positive patients remains essential to identify patients and to initiate antiviral treatment if needed to reduce the risk of serious liver disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.18238","type":"journal-article","created":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T18:37:59Z","timestamp":1743878279000},"page":"841-847","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Low rate of hepatitis Delta virus co\u2010infection in first\u2010time blood donors diagnosed with chronic hepatitis B virus infection in the Netherlands"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6934-5056","authenticated-orcid":false,"given":"Thijs J. W.","family":"van de Laar","sequence":"first","affiliation":[{"name":"Department of Donor Medicine Research Sanquin Research  Amsterdam The Netherlands"},{"name":"Department of Medical Microbiology Onze Lieve Vrouwe Gasthuis  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lesley A.","family":"Patmore","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Erasmus MC University Medical Centre  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel M.","family":"Molier","sequence":"additional","affiliation":[{"name":"Department of Donor Medicine Research Sanquin Research  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milan J.","family":"Sonneveld","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Erasmus MC University Medical Centre  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jolanda J. C.","family":"Voermans","sequence":"additional","affiliation":[{"name":"Department of Viroscience, Erasmus MC University Medical Centre  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ed","family":"Slot","sequence":"additional","affiliation":[{"name":"Department of Medical Affairs Sanquin Corporate Staff  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariet C. W.","family":"Feltkamp","sequence":"additional","affiliation":[{"name":"Department of Donor Medicine Research Sanquin Research  Amsterdam The Netherlands"},{"name":"Department of Medical Microbiology Leiden University Medical Centre  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annemiek A.","family":"van der Eijk","sequence":"additional","affiliation":[{"name":"Department of Viroscience, Erasmus MC University Medical Centre  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0773-7315","authenticated-orcid":false,"given":"Hans L.","family":"Zaaijer","sequence":"additional","affiliation":[{"name":"Department of Donor Medicine Research Sanquin Research  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.23242"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000642"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-023-07960-y"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiz633"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.04.008"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-316601"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.02.041"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.10.043"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2024.05.001"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2023.150769"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13713"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/v15020409"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.15161"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2017.12.011"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2021.104870"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16543"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/v14112507"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i23.7152"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/v14081749"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2024.01.035"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2024.06.031"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.05.001"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-77737-4"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2025.30.7.2400344"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17190"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.18238","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T05:54:01Z","timestamp":1753682041000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.18238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,4]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1111\/trf.18238"],"URL":"https:\/\/doi.org\/10.1111\/trf.18238","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"type":"print","value":"0041-1132"},{"type":"electronic","value":"1537-2995"}],"subject":[],"published":{"date-parts":[[2025,4,4]]},"assertion":[{"value":"2025-02-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}