{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T18:54:56Z","timestamp":1754160896684,"version":"3.41.2"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T00:00:00Z","timestamp":1744243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Early detection and intervention for fetal hemolytic disease are essential to prevent severe complications. This study evaluates the antenatal and postnatal clinical and laboratory characteristics of newborns who underwent intrauterine intravascular transfusion due to anti\u2010D\u2010induced hemolytic disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>Twenty newborns who received intrauterine transfusions between 18 and 35\u2009weeks of gestation were included. Data on maternal history, transfusion frequency, birth anthropometrics, ABO blood group, D typing, laboratory findings, morbidities, and hospitalization duration were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen cases (65%) had anti\u2010D antibody titers \u22651:1024. Intrauterine transfusions were administered once in 55% of cases, twice in 15%, and three or more times in 30%, with a mean gestational age of 29.6\u2009\u00b1\u20092.3\u2009weeks. The mean birth weight and gestational age were 2478.7\u2009\u00b1\u2009222.03\u2009g and 35.6\u2009\u00b1\u20092.08\u2009weeks, respectively. Severe hyperbilirubinemia requiring treatment was present in 50% of newborns, while 50% exhibited anemia\u2010related complications. Hypoxic\u2013ischemic encephalopathy and intracranial hemorrhage were observed in 55% and 45% of cases, respectively. Exchange transfusions were required in 65% (once) and 10% (twice) of cases. All newborns received standard hemolytic disease treatments, including high\u2010intensity phototherapy (94.3\u2009\u00b1\u200922.4\u2009h), infusion therapy (packed red cell transfusions, 10\u2009mL\/kg, 8\u2009\u00b1\u20092 times), and intravenous immunoglobulin (0.5\u20131\u2009g\/kg, 6\u2009\u00b1\u20091 times).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Newborns with anti\u2010D\u2010alloimmunization\u2010induced hemolytic disease requiring intrauterine transfusion demand intensive neonatal care to manage anemia, hyperbilirubinemia, hypoxic\u2013ischemic encephalopathy, and intracranial hemorrhage.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.18248","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T10:39:26Z","timestamp":1744281566000},"page":"985-991","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Several features of newborns following intrauterine intravascular blood transfusion for fetal hemolytic disease caused by anti\u2010D alloimmunization"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1508-1056","authenticated-orcid":false,"given":"Altay","family":"Babacan","sequence":"first","affiliation":[{"name":"Department of Pediatrics Ufuk University Faculty of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selenay Sevinc","family":"Sarklioglu","sequence":"additional","affiliation":[{"name":"Department of Genetic Medicine Weill Cornell Medicine  New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerem","family":"Cavus","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Ufuk University, Faculty of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serdar \u00dcmit","family":"Sarici","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ufuk University, Faculty of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2015.1.146"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/PHMT.S327032"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2013.04.021"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-017-1420-7"},{"key":"e_1_2_10_6_1","first-page":"73","article-title":"Diagnosis, treatment, prevention of hemolytic disease of the fetus is RH sensitization","volume":"6","author":"Savelyeva G","year":"2006","journal-title":"Ros Vestn Perinatal i Pediatr"},{"key":"e_1_2_10_7_1","unstructured":"ShabalovNP.Neonatology\/Textbook Vol. 2 \u2013 \u0422\u0418 \u2013 4th ed. 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[Updated 2022 Nov 22]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 20232022https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK557423Accessed 02 Oct 2023."},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.864609"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.18295\/squmj.2018.18.01.006"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.14746"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.18248","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T05:54:18Z","timestamp":1753682058000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.18248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,10]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1111\/trf.18248"],"URL":"https:\/\/doi.org\/10.1111\/trf.18248","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"type":"print","value":"0041-1132"},{"type":"electronic","value":"1537-2995"}],"subject":[],"published":{"date-parts":[[2025,4,10]]},"assertion":[{"value":"2024-05-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}