{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T15:05:10Z","timestamp":1789657510884,"version":"4.0.1"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The increasing use of extracorporeal membrane oxygenation (ECMO) has highlighted challenges in managing bleeding complications. Optimal transfusion strategies remain uncertain for this diverse patient group, necessitating accurate predictive tools. This study developed and validated a machine learning (ML) algorithm to predict bleeding complications in patients with ECMO, using red blood cell (RBC) transfusion as a surrogate marker.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data from the Tokushukai Medical Database (2018\u20132022), covering 71 hospitals, were used. An ML approach was employed to predict bleeding complications, using RBC transfusion events as a surrogate marker. Model performance was evaluated using precision, recall, F1 score, and accuracy. SHapley Additive exPlanations (SHAP) analysis was conducted to identify key factors influencing model predictions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Out of 470 ECMO\u2010treated intensive care unit patients, 357 were included for model development. Forty\u2010seven variables were used, with the light gradient boosting machine (LightGBM) and random forest models performing better than the other models, with receiver operating characteristic (ROC) area under the curve (AUC) above 0.7 for both (accuracy: 70.5%, ROC AUC: 0.703, recall: 0.784, and ROC AUC: 0.705, respectively). Models such as extreme gradient boosting performed similarly, while support vector classification had the lowest performance. SHAP analysis identified circulating blood volume, hemoglobin, and weight as the most important predictive factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The LightGBM and Random Forest models effectively predict bleeding complications in patients with ECMO, using RBC transfusion as a surrogate marker. This tool can support early identification of high\u2010risk patients and improve overall transfusion management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.18261","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T08:08:44Z","timestamp":1745568524000},"page":"1051-1060","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Machine learning\u2010based prediction of bleeding risk in extracorporeal membrane oxygenation patients using transfusion as a surrogate marker"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8987-0103","authenticated-orcid":false,"given":"Tadashi","family":"Kamio","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine Jichi Medical University Saitama Medical Center  Saitama Japan"},{"name":"Division of Critical Care Shonan Kamakura General Hospital  Kamakura Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Ikegami","sequence":"additional","affiliation":[{"name":"Terumo Corporation Shonan Center  Nakai\u2010machi Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megumi","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Terumo Corporation Shonan Center  Nakai\u2010machi Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiichiro","family":"Ishii","sequence":"additional","affiliation":[{"name":"Terumo Corporation Shonan Center  Nakai\u2010machi Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayato","family":"Tajima","sequence":"additional","affiliation":[{"name":"Terumo Corporation Shonan Center  Nakai\u2010machi Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihito","family":"Machida","sequence":"additional","affiliation":[{"name":"Terumo Corporation Shonan Center  Nakai\u2010machi Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2262-1898","authenticated-orcid":false,"given":"Kiyomitsu","family":"Fukaguchi","sequence":"additional","affiliation":[{"name":"Division of Critical Care Shonan Kamakura General Hospital  Kamakura Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2017-311928"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-023-04572-w"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-021-06593-x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2020.09.004"},{"key":"e_1_2_10_6_1","unstructured":"Extracorporeal Life Support Organization.General guidelines for all ECLS cases (Version 1.4). ELSO.2017.https:\/\/www.elso.org\/Resources\/Guidelines.aspx. Accessed date October 30 2024."},{"key":"e_1_2_10_7_1","first-page":"CD002042","article-title":"Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion","volume":"10","author":"Carson JL","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/membranes11040251"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17582"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-03403-6"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000003493"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10916-008-9220-2"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfy011"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13017-020-00303-6"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare10112146"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000003050"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.04.009"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.009449"},{"key":"e_1_2_10_19_1","volume-title":"Treasure Island (FL) ineligible companies. Disclosure: Sandeep Sharma declares no relevant financial relationships with ineligible companies: StatPearls Publishing copyright \u00a92024. 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