{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T15:04:27Z","timestamp":1789657467873,"version":"4.0.1"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Many blood services defer blood donors with out\u2010of\u2010range blood pressure (BP) readings, but evidence supporting this practice is equivocal. This study assessed the association of pre\u2010donation BP with vasovagal reactions (VVR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design and Methods<\/jats:title>\n                    <jats:p>Up until April 2020 (\u201cpre\u2010pandemic period\u201d), donors in Qu\u00e9bec (Canada) were deferred if their pre\u2010donation systolic BP was within &lt;90 to &gt;180\u2009mmHg, or if their pre\u2010donation diastolic BP was within &lt;50 to &gt;100\u2009mmHg. Between June 2022 and December 2023 (\u201clate\u2010pandemic period\u201d), BP was measured, but donors with out\u2010of\u2010range readings were no longer deferred. The analysis assessed the association of pre\u2010donation BP with on\u2010site VVRs during the late\u2010pandemic period and compared the rates of on\u2010site VVRs during the pre\u2010pandemic and late\u2010pandemic periods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>189,329 donors made 532,042 donations (mean age\u2009=\u200944.9\u2009years). Overall, 15,825 VVRs occurred, including 14,974 (94.8%) mild VVRs and 15,634 (99.0%) among donors with a normal BP. After adjustment for age, sex, and first\u2010time\/repeat status, the odds ratio of VVRs in donors with a low BP was 1.03 (95% confidence interval [CI]\u2009=\u20090.67\u20131.63) and 0.96 (95% CI\u2009=\u20090.81\u20131.14) in donors with a high BP, compared to donors with a normal BP. Finally, the VVR rate (95% CI) was 3.0% (2.9%\u20133.1%) during the pre\u2010pandemic period and 3.1% (3.0%\u20133.1%) during the late\u2010pandemic period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>There was no association between pre\u2010donation BP and the odds of VVR. The incidence of VVR did not increase after withdrawing the BP deferral. This study provides the most compelling evidence in support of withdrawing BP deferrals in blood donors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.18264","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:55:47Z","timestamp":1745888147000},"page":"1083-1091","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Deferring blood donors with out\u2010of\u2010range blood pressure: Does it decrease the risk of adverse reactions?"],"prefix":"10.1111","volume":"65","author":[{"given":"Catherine","family":"Thibeault","sequence":"first","affiliation":[{"name":"Medical Affairs and Innovation H\u00e9ma\u2010Qu\u00e9bec, Montr\u00e9al  Qu\u00e9bec City Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1748-4198","authenticated-orcid":false,"given":"Antoine","family":"Lewin","sequence":"additional","affiliation":[{"name":"Medical Affairs and Innovation H\u00e9ma\u2010Qu\u00e9bec, Montr\u00e9al  Qu\u00e9bec City Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Rabusseau","sequence":"additional","affiliation":[{"name":"Medical Affairs and Innovation H\u00e9ma\u2010Qu\u00e9bec  Qu\u00e9bec QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Germain","sequence":"additional","affiliation":[{"name":"Medical Affairs and Innovation H\u00e9ma\u2010Qu\u00e9bec  Qu\u00e9bec QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01745.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2003.00478.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2003.00368.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17173"},{"key":"e_1_2_8_6_1","unstructured":"World Health Organization.Blood donor selection \u2013 guidelines on assessing donor suitability for blood donation [Internet]. [cited 2024 Aug 14]. Available from:https:\/\/www.who.int\/publications\/i\/item\/9789241548519"},{"key":"e_1_2_8_7_1","unstructured":"European Directorate for the Quality of Medicines & HealthCare (EQDM).Guide to the preparation use and quality assurance of blood components [Internet]. [cited 2024 Aug 14]. Available from:https:\/\/freepub.edqm.eu\/publications\/AUTOPUB_48\/detail"},{"key":"e_1_2_8_8_1","unstructured":"US Food and Drug Administration.Blood pressure and pulse donor eligibility requirements \u2013 compliance policy [Internet]. [cited 2024 Sep 17]. Available from:https:\/\/www.fda.gov\/regulatory\u2010information\/search\u2010fda\u2010guidance\u2010documents\/blood\u2010pressure\u2010and\u2010pulse\u2010donor\u2010eligibility\u2010requirements\u2010compliance\u2010policy"},{"issue":"99","key":"e_1_2_8_9_1","first-page":"29841","article-title":"Requirements for blood and blood components intended for transfusion or for further manufacturing use. Final rule","volume":"80","author":"Food and Drug Administration, HHS","year":"2015","journal-title":"Fed Regist"},{"issue":"1","key":"e_1_2_8_10_1","first-page":"s28","article-title":"Risk factors for complications in donors at first and repeat whole blood donation: a cohort study with assessment of the impact on donor return","volume":"12","author":"Wiersum\u2010Osselton JC","year":"2014","journal-title":"Blood Transfus"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0148854"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/ajts.AJTS_111_17"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16603"},{"issue":"4","key":"e_1_2_8_14_1","first-page":"200","article-title":"Frequency of adverse events during blood and apheresis donations: a single\u2010center study","volume":"29","author":"Franchini M","year":"2002","journal-title":"Infusionsther Transfusionsmed"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03432.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1980.20681057157.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2012.04.002"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1999.39399219291.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12772"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jash.2014.03.332"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16375"},{"key":"e_1_2_8_22_1","unstructured":"Legifrance.Arr\u00eat\u00e9 du 17 d\u00e9cembre 2019 fixant les crit\u00e8res de s\u00e9lection des donneurs de sang [Internet]. Available from:https:\/\/www.legifrance.gouv.fr\/loda\/id\/JORFTEXT000039667225\/"},{"key":"e_1_2_8_23_1","unstructured":"ThibeaultC Desch\u00eanesJ RenaudC GermainM Gr\u00e9goireY LewinA et al.Adverse reactions amid a suspension of donor blood pressure measurement: a retrospective observational study in Qu\u00e9bec. Toronto Canada. [cited 2024 Sep 17]. 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