{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T17:04:34Z","timestamp":1772643874972,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007403","name":"Dagmar Marshalls Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007403","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Platelet transfusions are frequently used in the Intensive Care Unit (ICU) as prophylaxis against bleeding complications. Several guidelines exist on when to administer platelet transfusions in the ICU, but studies indicate that these guidelines are not necessarily followed. The aim of this qualitative study was to understand how experienced ICU physicians make decisions on prescribing prophylactic platelet transfusions and to gain insight into their general concerns and views on blood product transfusions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Descriptive qualitative study using semi\u2010structured, in\u2010depth interviews with clinicians working in ICUs in Austria, Denmark, France, Germany, Spain, and the United Kingdom. The <jats:bold>i<\/jats:bold>nterviews were recorded, transcribed verbatim, and analyzed using thematic analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified four main themes influencing the decision to prescribe prophylactic platelet transfusions: Guidelines, social and cultural aspects (including religion), previous personal experiences, and fear of consequences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Most doctors expressed uncertainty about balancing benefits and harm. Platelet transfusions were often used to prevent bleeding despite uncertainty on the effect and were typically triggered by fear of consequences when performing a procedure, which was an important driver. The departmental culture and colleagues' attitudes were far more important influencers on decision\u2010making than guideline recommendations. Most doctors thought it was possible for blood products to transfer unknown and potentially harmful substances to patients, although this did not appear to influence their daily practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.18290","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T13:51:46Z","timestamp":1748353906000},"page":"1231-1241","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["How experienced <scp>ICU<\/scp> specialists make decisions on prophylactic platelet transfusions\u2014A qualitative study"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7352-8728","authenticated-orcid":false,"given":"Lene","family":"Russell","sequence":"first","affiliation":[{"name":"Department of Intensive Care Medicine Copenhagen University Hospital\u2014Gentofte  Hellerup Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"},{"name":"Medical Intensive Care Unit Saint\u2010Louis University Hospital  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn","family":"Puxty","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Glasgow Royal Infirmary  Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elie","family":"Azoulay","sequence":"additional","affiliation":[{"name":"Medical Intensive Care Unit Saint\u2010Louis University Hospital  Paris France"},{"name":"Famirea Study Group Universit\u00e9 Paris Cit\u00e9 University (EA)  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne","family":"McPeake","sequence":"additional","affiliation":[{"name":"The Healthcare Improvement Studies Institute University of Cambridge  Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Kentish\u2010Barnes","sequence":"additional","affiliation":[{"name":"Medical Intensive Care Unit Saint\u2010Louis University Hospital  Paris France"},{"name":"Famirea Study Group Universit\u00e9 Paris Cit\u00e9 University (EA)  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10943-016-0353-1"},{"key":"e_1_2_9_3_1","first-page":"14","article-title":"Blood and blood\u2010associated symbols beyond medicine and transfusion: far more complex than first appears","volume":"12","author":"Garraud O","year":"2014","journal-title":"Blood Transfus"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.00892.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2012.03866.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.76.1734"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17064"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.13699"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.7326\/M14-1589"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-019-05884-8"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14423"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13555"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-019-2591-6"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16561"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-023-07225-2"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/14780887.2020.1769238"},{"key":"e_1_2_9_17_1","first-page":"376","volume-title":"Thematic analysis. 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