{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T17:09:27Z","timestamp":1792343367505,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Alpha\u2010gal syndrome (AGS) is caused by IgE antibodies against the alpha\u2010gal oligosaccharide, which is structurally similar to the Group B antigen. Recent case reports of severe allergic transfusion reactions (ATRs) in Group O patients receiving Group B plasma and platelets raise the possibility of a new adverse event, herein called transfusion\u2010related AGS (TRAGS). The primary goal of this study was to assess the frequency of Groups B and AB plasma and platelet transfusions to Group O patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design and Methods<\/jats:title>\n                    <jats:p>In this multi\u2010site retrospective study, participating sites submitted the numbers of platelet and plasma transfusions administered during a 2\u2010year period categorized by patient and product ABO group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fourteen sites from 10 countries participated. Group O patients received Group AB for an average of 9.9% (range 2.8%\u201329.2%) of plasma transfusions and Group B for 3.2% (0%\u201312.8%). AB plasma transfusion to Group O patients represented 4.5% (0.9%\u201314.6%) of the total plasma transfused; Group B 1.4% (0%\u20135.1%). Group O patients received Group AB for an average of 1.5% (range 0%\u20135.9%) of platelet transfusions and Group B for 4.1% (0%\u201314.2%). AB platelet transfusion to Group O patients represented 0.6% (0%\u20132.7%) of the total platelets transfused; Group B platelets were 1.8% (0%\u20136.7%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Evidence supporting the possibility of a new adverse event, TRAGS, is accumulating. This study quantifies how often Group O patients may be exposed to Group B antigen in Group B or AB plasma and\/or platelet transfusions, providing an estimate of the scope of potential risk for TRAGS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.18338","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T11:58:37Z","timestamp":1752235117000},"page":"1621-1629","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["<scp>ABO<\/scp>\n                    \u2010mismatched platelet and plasma transfusion practices and the potential for transfusion\u2010related alpha\u2010gal syndrome: The Biomedical Excellence for Safer Transfusion Collaborative Study"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8601-5438","authenticated-orcid":false,"given":"Nancy M.","family":"Dunbar","sequence":"first","affiliation":[{"name":"Dartmouth Hitchcock Medical Center  Lebanon New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0041-804X","authenticated-orcid":false,"given":"Richard M.","family":"Kaufman","sequence":"additional","affiliation":[{"name":"Dartmouth Hitchcock Medical Center  Lebanon New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina S.","family":"Bary","sequence":"additional","affiliation":[{"name":"M\u2010Health Fairview  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory R. 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