{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T18:52:26Z","timestamp":1758048746481,"version":"3.44.0"},"reference-count":10,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cold agglutinins are IgM\u2010mediated autoimmune hemolytic processes that most often cause destruction of red blood cells at colder temperatures. Here we describe a case of a patient with history of living donor renal transplantation that developed an atypical autoantibody causing profound anemia and hemolysis which, although IgM in nature, reacted best at warmer temperatures and was caused by a lymphoproliferative disorder. The investigations and serological findings here raise awareness to less common forms of autoimmune hemolytic disorders and describe specialized tests that can help uncover these antibodies. This case also highlights a rare presentation of post\u2010transplant lymphoproliferative disorder manifesting clinically as hemolytic anemia.<\/jats:p>","DOI":"10.1111\/trf.18353","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T06:39:13Z","timestamp":1753425553000},"page":"1756-1760","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rare case of warm <scp>IgM<\/scp> autoimmune hemolytic anemia"],"prefix":"10.1111","volume":"65","author":[{"given":"Bryan","family":"Tordon","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Calgary  Calgary Alberta Canada"},{"name":"Alberta Precision Laboratories (Formerly Calgary Laboratory Services)  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nour","family":"Alhomsi","sequence":"additional","affiliation":[{"name":"Hamilton Health Sciences Transfusion Medicine  Hamilton Ontario Canada"},{"name":"Department of Pathology and Laboratory Medicine McMaster University  Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Iqbal","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine McMaster University  Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azim","family":"Gangji","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine McMaster University  Hamilton Ontario Canada"},{"name":"Department of Education &amp; Learning St. Joseph's Healthcare Hamilton  Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gwen","family":"Clarke","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Alberta  Edmonton Alberta Canada"},{"name":"Department of Laboratory Medicine and Pathology Island Heath  Victoria British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7675-4058","authenticated-orcid":false,"given":"Shuoyan","family":"Ning","sequence":"additional","affiliation":[{"name":"Hamilton Health Sciences Transfusion Medicine  Hamilton Ontario Canada"},{"name":"Department of Pathology and Laboratory Medicine McMaster University  Hamilton Ontario Canada"},{"name":"Division of Hematology, Department of Medicine McMaster University  Hamilton Ontario Canada"},{"name":"Canadian Blood Services  Ancaster Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01957.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2019.100648"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000204666"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000461976"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200105000-00015"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.1291-18"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2015.05.001"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1974.tb02446.x"},{"key":"e_1_2_7_10_1","first-page":"447","volume-title":"Judd's methods in immunohematology","author":"Judd WJ","year":"2008"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.21307\/immunohematology-2020-004"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.18353","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T10:03:32Z","timestamp":1757757812000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.18353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,24]]},"references-count":10,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1111\/trf.18353"],"URL":"https:\/\/doi.org\/10.1111\/trf.18353","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"type":"print","value":"0041-1132"},{"type":"electronic","value":"1537-2995"}],"subject":[],"published":{"date-parts":[[2025,7,24]]},"assertion":[{"value":"2024-12-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}