{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T06:02:58Z","timestamp":1763186578940,"version":"3.45.0"},"reference-count":17,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:00:00Z","timestamp":1758758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2025,11]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Deficiency of Rh antigens affects the red blood cell (RBC) membrane integrity, thus reducing erythrocyte survival, clinically manifesting as chronic hemolytic anemia. Various mutations cause such Rh\n null\/mod<\/jats:sub>\n phenotypes. Parvovirus B19 infection causes transient red cell aplasia, leading to potentially severe anemia in patients with chronic hemolytic disorders.\n <\/jats:p>\n <\/jats:sec>\n \n Study Design and Methods<\/jats:title>\n A patient with known, etiologically unclear mild chronic anemia presented with a syncopal event. Clinical and laboratory work\u2010up, including targeted genetic analyses of RBC genes, was performed.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The patient was severely anemic with moderate signs of hemolysis and evidence of impaired erythropoiesis. Immunohematological work\u2010up identified a lack of Rh antigen expression. A homozygous\n c.1034G>A<\/jats:italic>\n missense mutation in\n RHAG<\/jats:italic>\n adequately explains this finding, as well as the chronic hemolysis. Parvovirus B19 was identified as causal for the acute aplastic crisis.\n <\/jats:p>\n <\/jats:sec>\n \n Discussion<\/jats:title>\n \n This is the first clinical report of parvovirus B19\u2010related red cell aplasia in a patient with the\n RHAG*01M.15<\/jats:italic>\n phenotype.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/trf.18378","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T05:21:27Z","timestamp":1758864087000},"page":"2203-2206","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transient severe anemia triggered by parvovirus\n B19<\/scp>\n infection in a patient with homozygous\n RhAG<\/scp>\n deficiency"],"prefix":"10.1111","volume":"65","author":[{"given":"Anna","family":"Hausdorf","sequence":"first","affiliation":[{"name":"German Red Cross Blood Service Baden\u2010W\u00fcrttemberg\u2010Hesse Institute Frankfurt Frankfurt am Main Germany"},{"name":"Department of Hematology and Oncology Municipal Hospital Frankfurt\u2010H\u00f6chst Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans\u2010G\u00fcnter","family":"Derigs","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Municipal Hospital Frankfurt\u2010H\u00f6chst Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0088-2675","authenticated-orcid":false,"given":"Halvard","family":"Bonig","sequence":"additional","affiliation":[{"name":"German Red Cross Blood Service Baden\u2010W\u00fcrttemberg\u2010Hesse Institute Frankfurt Frankfurt am Main Germany"},{"name":"Goethe University Medical School Institute for Transfusion Medicine and Immunohematology Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Fleck","sequence":"additional","affiliation":[{"name":"German Red Cross Blood Service Baden\u2010W\u00fcrttemberg\u2010Hesse Institute Frankfurt Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0038-385X","authenticated-orcid":false,"given":"Susanne","family":"Braeuninger","sequence":"additional","affiliation":[{"name":"German Red Cross Blood Service Baden\u2010W\u00fcrttemberg\u2010Hesse Institute Frankfurt Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,25]]},"reference":[{"volume-title":"Guideline on haemoglobin cutoffs to define anaemia in individuals and populations","year":"2024","author":"World Health Organization","key":"e_1_2_4_2_1"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.1039"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(61)92183-3"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0037-1963(00)90040-4"},{"issue":"6","key":"e_1_2_4_6_1","first-page":"623","article-title":"An unlinked modifier of Rh blood groups: effects when heterozygous and when homozygous","volume":"24","author":"Chown B","year":"1972","journal-title":"Am J Hum Genet"},{"key":"e_1_2_4_7_1","unstructured":"International Society of Blood Transfusion (ISBT).(ISBT 030) RHAG blood group alleles v6.4 31\u2010JUL\u20102023. ISBT Amsterdam.https:\/\/www.isbtweb.org\/Accessed 16 Jan 2025"},{"issue":"1","key":"e_1_2_4_8_1","first-page":"204","article-title":"A blood donor with Rhmod phenotype detected by RHD PCR","volume":"117","author":"Wagner FF","year":"2022","journal-title":"Vox Sang"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V36.3.310.310"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V63.5.1046.1046"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830240306"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/beha.1999.0047"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2010.01388.x"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0296-168"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13476"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15792"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00040-16"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1996.36496226154.x"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.18378","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T05:58:09Z","timestamp":1763186289000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.18378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,25]]},"references-count":17,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/trf.18378"],"URL":"https:\/\/doi.org\/10.1111\/trf.18378","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"type":"print","value":"0041-1132"},{"type":"electronic","value":"1537-2995"}],"subject":[],"published":{"date-parts":[[2025,9,25]]},"assertion":[{"value":"2024-10-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}