{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:19:06Z","timestamp":1788347946512,"version":"build-2803163510"},"reference-count":12,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>H\u00e9ma\u2010Qu\u00e9bec (Qu\u00e9bec, Canada) currently defers prospective blood donors for 3, 6, or 12\u2009months depending on their self\u2010reported risk factors for hepatitis B virus (HBV) infection. However, this policy may be needlessly complex and overly cautious, thereby potentially causing confusion among donors and deferring those with an acceptable safety profile. Based on published window period estimates, a uniform deferral period of 3 or 4 months may be considered. To inform our policy update, we estimated the incremental risk of adopting an HBV deferral period of 4 months versus 3 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design and Methods<\/jats:title>\n                    <jats:p>This probit analysis was an adaptation of the Weusten model. The analysis considered the characteristics of the current nucleic acid test (NAT)\u2010HBV assay (i.e., Procleix Ultrio plus assay in minipools of 16) and HBV viral dynamics. The incremental risk of banking an HBV\u2010contaminated whole blood donation was evaluated through a Monte\u2010Carlo simulation in which 10,000 infected donors were simulated; corresponding to 833\u2009years of observation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The window period for the NAT 50% endpoint limit of detection (LOD\n                      <jats:sub>50<\/jats:sub>\n                      ) was estimated at 34.5\u2009days (range\u2009=\u200912.4\u2013136.5), and 28.2\u2009days (range\u2009=\u200910.1\u2013111.4) for the LOD\n                      <jats:sub>95<\/jats:sub>\n                      . Of the 10,000 simulated infected donors, 32 (and 104 using an eclipse phase [EP] of 8\u2009days) would test negative by NAT between 3 and 4 months post\u2010HBV exposure, corresponding to one HBV contamination every 7.8 (or 2.4 using the 8\u2010day EP) million donations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Adopting an HBV deferral of 3 months poses a negligible incremental risk compared with 4 months and is acceptable given the resulting gain in newly eligible donors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.18381","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T09:06:08Z","timestamp":1755162368000},"page":"1793-1797","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>HBV<\/scp>\n                    deferrals and\n                    <scp>NAT<\/scp>\n                    window period: Assessing the impact of 3\u2010month versus 4\u2010month testing delays"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1748-4198","authenticated-orcid":false,"given":"Antoine","family":"Lewin","sequence":"first","affiliation":[{"name":"Medical Affairs and Innovation, H\u00e9ma\u2010Qu\u00e9bec  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Germain","sequence":"additional","affiliation":[{"name":"Medical Affairs and Innovation, H\u00e9ma\u2010Qu\u00e9bec  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Lachance","sequence":"additional","affiliation":[{"name":"Medical Affairs and Innovation, H\u00e9ma\u2010Qu\u00e9bec  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5332-2789","authenticated-orcid":false,"given":"Sheila","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Epidemiology and Surveillance, Canadian Blood Services  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katy","family":"Davison","sequence":"additional","affiliation":[{"name":"NHSBT and UK Health Security Agency (UKHSA) Epidemiology Unit, UKHSA  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0773-7315","authenticated-orcid":false,"given":"Hans","family":"Zaaijer","sequence":"additional","affiliation":[{"name":"Department of Blood\u2010Borne Infections, Donor Medicine Research Sanquin Blood Supply Foundation  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Renaud","sequence":"additional","affiliation":[{"name":"Medical Affairs and Innovation, H\u00e9ma\u2010Qu\u00e9bec  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,14]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"US FDA.Revised recommendations for reducing the risk of human immunodeficiency virus transmission by blood and blood products [Internet].2023. Report No.: 85 FR 15417 [cited 2025]. 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