{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T02:08:44Z","timestamp":1791166124232,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1177784"],"award-info":[{"award-number":["1177784"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1194811"],"award-info":[{"award-number":["1194811"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["2009177"],"award-info":[{"award-number":["2009177"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1151512"],"award-info":[{"award-number":["APP1151512"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001779","name":"Monash University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001779","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015675","name":"National Blood Authority","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015675","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003463","name":"Haematology Society of Australia and New Zealand","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003463","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Evidence guiding optimal transfusion practice for patients with myelodysplastic syndromes (MDS) is lacking. Many patients have concurrent cardiac disease. Data on practice are sparse. We aimed to describe the use of red blood cell (RBC) transfusion and the prevalence of cardiac comorbidities in patients with MDS within Australia's largest public hospital network to better understand real\u2010world practices and outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort study of patients aged \u226518\u2009years with MDS, MDS\/myeloproliferative overlap neoplasm or chronic myelomonocytic leukemia admitted from 2016 to 2018 to determine RBC transfusion\u2010related endpoints.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One hundred and seventy\u2010nine patients (median age 78\u2009years, 61.5% male) were included, with a median follow\u2010up of 46\u2009weeks. Of these, 102 (57.0%) received RBC transfusion. Transfused patients had lower presenting Hb (87 vs. 105\u2009g\/L,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), higher rates of cardiac disease (29.4% vs. 12.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009) and 5\u2010azacytidine use (31.4% vs. 13.0%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004). Sixty\u2010five patients (36.3%) received outpatient RBC transfusions, with a median of 2\u2009units RBC per transfusion and 14\u2009days between transfusions. The median pre\u2010transfusion Hb was 80\u2009g\/L (IQR 74\u201386\u2009g\/L). Forty patients (22.4%) had evidence of cardiac disease, with similar pre\u2010transfusion Hb for patients with and without cardiac disease (median Hb 79\u2009g\/L vs. 81\u2009g\/L,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.1).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Patients with MDS frequently require RBC transfusion, and restrictive transfusion strategies predominate despite many patients having cardiac comorbidities. Further research is needed to address optimal transfusion strategies in such patients and associated cardiac outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.18391","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T09:41:11Z","timestamp":1756460471000},"page":"1803-1809","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Red blood cell transfusion practice and cardiac comorbidities in patients with myelodysplastic syndromes"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1923-3133","authenticated-orcid":false,"given":"Allison","family":"Mo","sequence":"first","affiliation":[{"name":"Transfusion Research Unit, School of Public Health &amp; Preventive Medicine, Faculty of Medicine, Nursing &amp; Health Sciences Monash University  Melbourne Australia"},{"name":"Monash Hematology, Monash Health  Melbourne Australia"},{"name":"Austin Pathology and Department of Haematology, Austin Health  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica M.","family":"Wood","sequence":"additional","affiliation":[{"name":"Transfusion Research Unit, School of Public Health &amp; Preventive Medicine, Faculty of Medicine, Nursing &amp; Health Sciences Monash University  Melbourne Australia"},{"name":"Monash Hematology, Monash Health  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jake","family":"Shortt","sequence":"additional","affiliation":[{"name":"Monash Hematology, Monash Health  Melbourne Australia"},{"name":"Department of Medicine, School of Clinical Sciences, Faculty of Medicine, Nursing &amp; Health Sciences Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9698-7185","authenticated-orcid":false,"given":"Zoe K.","family":"McQuilten","sequence":"additional","affiliation":[{"name":"Transfusion Research Unit, School of Public Health &amp; Preventive Medicine, Faculty of Medicine, Nursing &amp; Health Sciences Monash University  Melbourne Australia"},{"name":"Monash Hematology, Monash Health  Melbourne Australia"},{"name":"Department of Haematology Alfred Health  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04272.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)00874-7"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(99)00113-7"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16946"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.02810"},{"key":"e_1_2_10_7_1","article-title":"Transfusion thresholds for guiding red blood cell transfusion","author":"Carson JL","year":"2021","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_8_1","article-title":"Restrictive versus liberal red blood cell transfusion strategies for people with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem cell support","volume":"5","author":"Radford M","year":"2024","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17540"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2023.101114"},{"key":"e_1_2_10_11_1","unstructured":"National Blood Authority.Module 3 Medical. 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