{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T22:15:08Z","timestamp":1788992108026,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T00:00:00Z","timestamp":1757203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T00:00:00Z","timestamp":1757203200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000014","name":"Canadian Blood Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000014","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Donors are deferred if they are on antiretroviral medications (ARV) as post\u2010exposure or pre\u2010exposure prophylaxis (PEP or PrEP) for human immunodeficiency virus (HIV). We assessed donor compliance by measuring ARV levels in selected anonymized donor samples collected from September 22, 2022 to December 31, 2024, almost all after the introduction of sexual risk behavior screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      EDTA plasma samples collected at the time of donation (retention samples) were retrieved, frozen, and shipped for measurement of tenofovir and emtricitabine. Samples were from randomly selected first\u2010time male donors in large urban areas (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009520), syphilis (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009133), or HIV (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096) confirmed positive donors, and donors deferred for PEP or PrEP use on a previous donation attempt who returned to successfully donate (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009225 tests, 115 unique donors). We compare our results to international studies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All samples from first\u2010time male donors, HIV\u2010positive donors, syphilis\u2010positive female donors, and female donors previously deferred for PEP or PrEP were negative. Three of 110 male syphilis\u2010positive donors (2.7%) and 14 of 85 male donors previously deferred for PEP or PrEP (16.5%) were positive for ARV. Eleven of these donors were tested multiple times, and 10 were positive more than once.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Results on syphilis\u2010positive male donors were similar to findings in England and the Netherlands. Noncompliance with criteria for ARV use was high in male donors previously deferred for PEP\/PrEP. Messaging regarding recipient risk is particularly difficult in this group, since it is at odds with the reduction in individual HIV risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.18393","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T10:30:29Z","timestamp":1757327429000},"page":"1869-1875","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Nondisclosure of use of antiretroviral medications in Canadian blood donors"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9904-9952","authenticated-orcid":false,"given":"Mindy","family":"Goldman","sequence":"first","affiliation":[{"name":"Medical Affairs and Innovation Canadian Blood Services  Ottawa Ontario Canada"},{"name":"Department of Pathology and Laboratory Medicine University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2519-1109","authenticated-orcid":false,"given":"Steven J.","family":"Drews","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanson","family":"Brumme","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Faculty of Medicine University of British Columbia  Vancouver British Columbia Canada"},{"name":"BC Centre for Excellence in HIV\/AIDS  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hope R.","family":"Lapointe","sequence":"additional","affiliation":[{"name":"BC Centre for Excellence in HIV\/AIDS  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7055-440X","authenticated-orcid":false,"given":"Timothy","family":"Tang","sequence":"additional","affiliation":[{"name":"BC Centre for Excellence in HIV\/AIDS  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori","family":"Osmond","sequence":"additional","affiliation":[{"name":"Medical Affairs and Innovation Canadian Blood Services  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5332-2789","authenticated-orcid":false,"given":"Sheila F.","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Medical Affairs and Innovation Canadian Blood Services  Ottawa Ontario Canada"},{"name":"School of Epidemiology and Public Health University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020006890"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2023.150754"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.170494"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000001577"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2024.107222"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13011"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12790"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020008122"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12993"},{"key":"e_1_2_8_11_1","unstructured":"Association for the Advancement of Blood & Biotherapies.Updated recommendations on donor deferral for use of antiretroviral medications for HIV prevention and treatment including long\u2010acting injectable PrEP and the impact on blood safety. AABB Association Bulletin #22\u201003.https:\/\/www.abhh.com.br\/acreditacao\/painel\/uploads\/61f229c0ca150dc1ce44c58dab6f1dc4.pdf. Accessed 28 August 2025."},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2021-054981"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2023.28.11.2300135"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17941"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.18275"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.14745\/ccdr.v48i23a01"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17393"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13773"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13587"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13033"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16349"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16753"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15623"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.18302"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.220645"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.18393","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/trf.18393","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.18393","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T07:23:13Z","timestamp":1771312993000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.18393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,7]]},"references-count":24,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1111\/trf.18393"],"URL":"https:\/\/doi.org\/10.1111\/trf.18393","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,7]]},"assertion":[{"value":"2025-06-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}