{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T17:09:26Z","timestamp":1792343366411,"version":"4.4.0"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T00:00:00Z","timestamp":1757203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T00:00:00Z","timestamp":1757203200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000038","name":"U.S. Food and Drug Administration","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The Transfusion\u2010Transmissible Infections Monitoring System assesses trends in ~60% of the US blood supply. Donors with high\u2010risk behaviors, including injection drug use, men having sex with other men, or exchanging sex for money\/drugs were deferred for 12\u2009months (12M) from 2016 to 2020 and 3\u2009months (3M) from 2020 to 2023. Here we evaluate HIV, HBV, and HCV incidence and window\u2010period residual risk (WPRR) in two ~3\u2010year periods of 12M (2017\u20132020) and 3M (2020\u20132023) to identify any differences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      First\u2010time (FT), repeat (RPT), and overall weighted incidence\/100,000 person\u2010years (phtpy) for HIV, HBV, and HCV were estimated based on serology and nucleic acid test results. WPRR was calculated by multiplying respective incidence by agent\u2010specific WP. Fisher's exact test evaluated incidence changes between the two periods (\n                      <jats:italic>\u03b1<\/jats:italic>\n                      \u2009=\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall weighted incidence for HIV, HBV, and HCV was 2.22, 1.59, and 0.53 phtpy versus 1.03, 0.93, and 0.16 phtpy in 12M and 3M periods, respectively. Overall WPRR per 1,000,000 donations for HIV, HBV, and HCV was 0.45, 0.63, and 0.53 versus 0.23, 0.43, and 0.16 in 12M and 3M periods, respectively. All comparisons by agent and by period were significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Despite reducing donor deferral periods for many infectious risk behaviors, HIV, HBV, and HCV overall incidence declined from the 12M to 3M periods. WPRR also declined from 12M to 3M, remaining under 1 per 2,000,000 donations in the 3M period. Thus, changes in policy did not adversely impact the safety of the blood supply with respect to the major infectious disease agents.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.18398","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T10:30:51Z","timestamp":1757327451000},"page":"1876-1887","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Incidence and window period residual risk of human immunodeficiency virus, hepatitis B virus, and hepatitis C virus in United States blood donations, 2017 to 2023: The transfusion\u2010transmissible infections monitoring system"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9106-1858","authenticated-orcid":false,"given":"Emilya","family":"Huseynova","sequence":"first","affiliation":[{"name":"Transfusion Safety and Surveillance American Red Cross  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Haynes","sequence":"additional","affiliation":[{"name":"Transfusion Safety and Surveillance American Red Cross  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward P.","family":"Notari","sequence":"additional","affiliation":[{"name":"Transfusion Safety and Surveillance American Red Cross  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Custer","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Vitalant Research Institute  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Reik","sequence":"additional","affiliation":[{"name":"OneBlood  St. Petersburg Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jed","family":"Gorlin","sequence":"additional","affiliation":[{"name":"Physician Services New York Blood Center Enterprises  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6848-1224","authenticated-orcid":false,"given":"Artur","family":"Belov","sequence":"additional","affiliation":[{"name":"Center for Biologics Evaluation and Research US Food and Drug Administration  Silver Spring Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benyam","family":"Hailu","sequence":"additional","affiliation":[{"name":"National Heart, Lung, and Blood Institute US National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbee","family":"Whitaker","sequence":"additional","affiliation":[{"name":"Center for Biologics Evaluation and Research US Food and Drug Administration  Silver Spring Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger Y.","family":"Dodd","sequence":"additional","affiliation":[{"name":"Transfusion Safety and Surveillance American Red Cross  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L.","family":"Stramer","sequence":"additional","affiliation":[{"name":"Infectious Disease Consultant  North Potomac Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,7]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"US Food and Drug Administration.Revised recommendations for reducing the risk of human immunodeficiency virus transmission by blood and blood products \u2010 Guidance for Industry. Published Apr 2020. Last updated Aug 2020. Accessed Apr 5. Retrieved from:https:\/\/www.fda.gov\/media\/92490\/download2025."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17707"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16250"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02804.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16005"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.18424"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02622.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17851"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12213"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020007003"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2024.104429"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13592"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-88530-2"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hsr2.2206"},{"key":"e_1_2_10_16_1","article-title":"Health landscapes in the south: rurality, racism, and a path forward","author":"Cafer A","year":"2020","journal-title":"Study the South"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2020.02.001"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02650.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-015-1036-8"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2012.10.006"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13726"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.18195"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.70469"},{"key":"e_1_2_10_24_1","unstructured":"NHS Blood and Transplant UK Health Security Agency.Safe Supplies 2022: monitoring safety in donors and recipients. Annual safety report shows no impact on safety since more gay and bisexual men were able to donate blood.2023Oct 12. Available from:https:\/\/www.nhsbt.nhs.uk\/news\/annual-safety-report-shows-no-impact-on-safety\/"},{"key":"e_1_2_10_25_1","volume-title":"Surveillance Report 2023","author":"O'Brien S","year":"2024"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.18398","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/trf.18398","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.18398","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T07:23:11Z","timestamp":1771312991000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.18398"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,7]]},"references-count":24,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1111\/trf.18398"],"URL":"https:\/\/doi.org\/10.1111\/trf.18398","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,7]]},"assertion":[{"value":"2025-07-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}