{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T03:23:34Z","timestamp":1772767414284,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012023","name":"Stichting Sanquin Bloedvoorziening","doi-asserted-by":"publisher","award":["PPOC12\u2010028\/ L1852"],"award-info":[{"award-number":["PPOC12\u2010028\/ L1852"]}],"id":[{"id":"10.13039\/501100012023","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The changes in platelet structure and function arising from its collection and storage are collectively called \u201cplatelet storage lesion.\u201d In patients this might potentially be associated with impaired hemostasis and adverse events. We performed a hypothesis\u2010generating retrospective study in cardiac surgery patients transfused with platelets in two hospitals between 2005 and 2017.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design and Methods<\/jats:title>\n                    <jats:p>We explored whether longer storage duration of platelets is associated with changes in in\u2010hospital mortality, blood loss after surgery, reoperation for bleeding, stroke, myocardial infarction, infection, systemic inflammatory response syndrome, shock, and multi\u2010organ failure in cardiac surgery patients. Platelet concentrates were classified as platelets with shorter storage duration (PSSD; stored 1\u20133\u2009days) or platelets with longer storage duration (PLSD; stored 4\u20137\u2009days). Associations between storage duration and endpoints were quantified using logistic regression adjusted for potential confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In patients transfused with PLSD, in\u2010hospital mortality (212\/2117; 10.0%) was significantly higher than in patients transfused with PSSD (109\/1439; 7.6%) (adjusted odds ratio [aOR] 1.47, 95% confidence interval [CI] 1.13\u20131.91). Patients transfused with PLSD experienced postoperative blood loss \u22651000\u2009mL (102\/285; 35.8%) significantly more frequently than patients transfused with PSSD (87\/326; 26.7%), aOR 1.74 (95% CI 1.19\u20132.52). In patients transfused with PLSD, the need for reoperation for bleeding (99\/285; 34.7%) was significantly higher than in patients transfused with PSSD (87\/326; 26.7%) (aOR 1.62, 95% CI 1.12\u20132.35). There was no notable association with other endpoints.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In cardiac surgery patients, transfusion of PLSD was associated with higher in\u2010hospital mortality, more blood loss, and reoperations for bleeding, compared to transfusion of PSSD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.18410","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T09:20:11Z","timestamp":1758100811000},"page":"2034-2044","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Storage duration of platelet concentrates and clinical outcomes in cardiac surgery patients"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3027-6406","authenticated-orcid":false,"given":"Fabienne M. A.","family":"van Hout","sequence":"first","affiliation":[{"name":"Department of Clinical Epidemiology Leiden University Medical Center  Leiden The Netherlands"},{"name":"Department of Cardiothoracic Surgery Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3161-5684","authenticated-orcid":false,"given":"Camila","family":"Caram\u2010Deelder","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aad","family":"Pors","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6545-7277","authenticated-orcid":false,"given":"Rutger A.","family":"Middelburg","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J. M.","family":"Klautz","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter M. J.","family":"Rosseel","sequence":"additional","affiliation":[{"name":"Department of Cardiac Anesthesiology and Intensive Care Amphia Hospital  Breda The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hendrik J. F.","family":"Helmerhorst","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Leiden University Medical Center  Leiden The Netherlands"},{"name":"Department of Intensive Care Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leo M. 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