{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T10:23:39Z","timestamp":1778754219982,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Platelet transfusions (PLT\u2010t) are a cornerstone of contemporary trauma resuscitation, but little is known about their use in the postresuscitation period. Our aims were to describe the utilization of PLT\u2010t after resuscitation and examine their impact on platelet count and clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design and Methods<\/jats:title>\n                    <jats:p>Adult trauma patients admitted to critical care at a single major trauma center were included. We compared patients who received PLT\u2010t postresuscitation (&gt;24\u2009h after injury) with those who did not and examined platelet increments before and after each individual PLT\u2010t episode. Logistic regressions were constructed to examine the association between postresuscitation PLT\u2010t and clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This study included 803 injured patients, of whom 109 (14%) received at least one PLT\u2010t after resuscitation. Overall, 30% (221\/725) of all platelet units administered to the cohort were given in the postresuscitation phase, most in the first week of admission and to patients with moderate\u2013severe thrombocytopenia. The median platelet count increment following transfusion was 19\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L (interquartile range 1\u201330), and 24% of transfusions failed to increase the platelet count within 24\u2009h. Postresuscitation PLT\u2010t in patients with moderate\u2013severe thrombocytopenia was independently associated with reduced mortality (OR 0.42,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.039) but a longer critical care length of stay among survivors (coefficient 0.35,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.007).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Postresuscitation PLT\u2010t is frequently administered in trauma patients. The impact on platelet counts is variable, likely attributable to differences in timing and pretransfusion platelet count. After adjusting for relevant confounders, postresuscitation PLT\u2010t was associated with reduced mortality in this cohort.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.18414","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T07:07:04Z","timestamp":1758265624000},"page":"2055-2064","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Postresuscitation platelet transfusion in major trauma patients"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9176-8351","authenticated-orcid":false,"given":"Andrea","family":"Rossetto","sequence":"first","affiliation":[{"name":"Centre for Trauma Sciences, Blizard Institute Queen Mary University of London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Barts Health National Health Service Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ella","family":"Ykema","sequence":"additional","affiliation":[{"name":"Centre for Trauma Sciences, Blizard Institute Queen Mary University of London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ross","family":"Davenport","sequence":"additional","affiliation":[{"name":"Centre for Trauma Sciences, Blizard Institute Queen Mary University of London  London UK"},{"name":"Barts Health National Health Service Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine","family":"Cole","sequence":"additional","affiliation":[{"name":"Centre for Trauma Sciences, Blizard Institute Queen Mary University of London  London UK"},{"name":"Barts Health National Health Service Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Vulliamy","sequence":"additional","affiliation":[{"name":"Centre for Trauma Sciences, Blizard Institute Queen Mary University of London  London UK"},{"name":"Barts Health National Health Service Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-022-03928-y"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018017699"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/sla.0000000000006317"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-020-06266-1"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-023-04327-7"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/ta.0000000000001333"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1807320"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(16)30392-0"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-10-605493"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00028"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-023-07225-2"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-019-2591-6"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpth.2025.102890"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtha.2023.05.005"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0000000000000859"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1702171"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-023-07135-3"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(07)60411-5"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-11-680744"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12919"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/sla.0000000000002825"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/shk.0000000000000779"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-7622-5-5"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(86)90290-1"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.19360"},{"key":"e_1_2_10_27_1","unstructured":"National Institute for Health and Care Excellence.Blood Transfusion (NICE Guideline 24). 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