{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T15:16:29Z","timestamp":1774278989352,"version":"3.50.1"},"reference-count":5,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2025,12]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n The e antigen is the highest prevalence antigen commonly encountered in the Rh blood system, while Di\n b<\/jats:sup>\n has a prevalence of nearly 100% in most populations studied. The immune response to these antigens is clinically significant with respect to hemolysis (hemolytic disease of the fetus\/newborn and hemolytic transfusion reactions).\n <\/jats:p>\n <\/jats:sec>\n \n Case Presentation<\/jats:title>\n \n A 33\u2010year\u2010old G6P4 pregnant woman presented for an initial prenatal visit. Anti\u2010e was detected at the time of delivery of her 5th baby. Initial blood bank testing for her 6th pregnancy revealed strong pan\u2010reactivity that proved to be anti\u2010e and anti\u2010Di\n b<\/jats:sup>\n . A combined antibody titer of 16 led to pregnancy monitoring using serial fetal middle cerebral artery Doppler sonography. All results were in the normal range, indicating a low risk for severe fetal anemia. The patient donated 3\u2009units of blood for autologous and\/or neonatal transfusion. She ultimately had a vaginal delivery at ~37\u2009weeks gestational age with minimal blood loss. Her neonate had a normal hemoglobin\/hematocrit at delivery and no clinical evidence of jaundice even though he had a strongly reactive DAT, typed positive for both e and Di\n b<\/jats:sup>\n , and had both antibodies eluted from his red cells. On close follow\u2010up, he developed mild jaundice but did not require treatment.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Though this pregnant patient had 2 clinically significant antibodies to high prevalence blood group antigens, they did not affect the neonate adversely. This case demonstrates that close collaboration between obstetricians, neonatologists, and transfusion medicine specialists is essential for positive patient outcomes in cases like this.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/trf.18439","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T06:06:10Z","timestamp":1760076370000},"page":"2423-2426","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Successful outcome of a pregnancy complicated by anti\u2010e and anti\u2010Di\n b<\/sup>"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1031-8816","authenticated-orcid":false,"given":"Douglas","family":"Blackall","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Services Providence Health and Services Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten","family":"Alcorn","sequence":"additional","affiliation":[{"name":"Bloodworks Northwest Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavan","family":"Parikh","sequence":"additional","affiliation":[{"name":"Women and Children's Services, Providence Health and Services Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-024-02186-w"},{"key":"e_1_2_6_3_1","volume-title":"The blood group antigen FactsBook","author":"Reid ME","year":"2012"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.00743.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/labmed\/lmac149"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211897"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.18439","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/trf.18439","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.18439","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T14:27:30Z","timestamp":1774276050000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.18439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,9]]},"references-count":5,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/trf.18439"],"URL":"https:\/\/doi.org\/10.1111\/trf.18439","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,9]]},"assertion":[{"value":"2025-06-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}