{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T18:43:37Z","timestamp":1786214617544,"version":"build-2736575974"},"reference-count":13,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2026,8]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Post\u2010transfusion purpura (PTP) is a rare and severe transfusion reaction characterized by rapid\u2010onset thrombocytopenia, typically occurring 1\u20132\u2009weeks after platelet or RBC transfusion. While PTP is commonly seen in patients with prior pregnancies or transfusions, its occurrence in trauma patients has rarely been reported. We present a case highlighting the challenges of PTP diagnosis and management in the post\u2010trauma setting.<\/jats:p>\n <\/jats:sec>\n \n Case Report<\/jats:title>\n \n A 38\u2010year\u2010old female was airlifted to Harborview Medical Center, Seattle, WA, USA, following a motor vehicle accident, requiring administration of blood products via massive transfusion protocol. On hospital Day 8, she developed abrupt and significant thrombocytopenia, with a drop in platelets from 157 \u00d7\u200910\n 3<\/jats:sup>\n \/uL to 3 \u00d7\u200910\n 3<\/jats:sup>\n \/uL by hospital Day 9. Surgical intervention, anticoagulation, and additional platelet transfusions were held for five days while a PTP workup was ordered and intravenous immunoglobulin (IVIG) therapy started. Despite concerns around halting acute surgical care, the platelet count steadily improved after 5\u2009days, allowing for reinitiation of surgical intervention. Additional testing revealed the presence of anti\u2010HPA\u20101a antibodies, confirming the diagnosis of PTP.\n <\/jats:p>\n <\/jats:sec>\n \n Discussion<\/jats:title>\n This case emphasizes the complexity of diagnosing PTP in the acute trauma setting following massive transfusion protocol. Effective communication between the transfusion medicine, hematology\/oncology, and trauma surgery teams was crucial to successfully manage this patient, highlighting the importance of a supportive multidisciplinary approach in these complex clinical scenarios.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/trf.18443","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T05:40:16Z","timestamp":1760420416000},"page":"1686-1689","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnosis and management of post\u2010transfusion purpura in the acute trauma setting: A case report"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8169-3991","authenticated-orcid":false,"given":"Tara","family":"Krishnan","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Washington Medical Center Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Washington Medical Center Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margery","family":"Gang","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology University of Washington Medical Center Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui Xiao","family":"Chao","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology University of Washington Medical Center Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Giustini","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology University of Washington Medical Center Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8596-4420","authenticated-orcid":false,"given":"John","family":"Hess","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Washington Medical Center Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0904084"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2018.00157"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.01787.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/JBM.S189176"},{"key":"e_1_2_7_6_1","unstructured":"WhitakerBI RajbhandaryS HarrisA.The 2013 AABB Blood Collection Utilization and Patient Blood Management Survey 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