{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:41:49Z","timestamp":1790883709987,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1189490"],"award-info":[{"award-number":["GNT1189490"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1194811"],"award-info":[{"award-number":["GNT1194811"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Transfusion practices among intensive care unit (ICU) patients with sepsis vary widely. While restrictive hemoglobin thresholds for red blood cell (RBC) transfusion are well studied, the indications and thresholds for platelet and plasma transfusions remain uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We performed a sepsis\u2010specific sub\u2010analysis of the\n                      <jats:italic>International Point Prevalence Study of Intensive Care Unit Transfusion Practices<\/jats:italic>\n                      , a prospective, multicenter, observational study capturing all adult ICU admissions during four pre\u2010scheduled weeks between March 2019 and October 2022. Patients admitted with sepsis or septic shock, or who developed sepsis during their ICU stay, were included. We recorded demographics, daily laboratory values, and transfusion triggers. Primary endpoints were the proportions of patients receiving RBCs, platelets, or plasma; secondary endpoints were indications, pre\u2010transfusion thresholds, and blood loss.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 3643 screened patients, 799 (22%) fulfilled sepsis criteria; within this subgroup, 317 (40%) received at least one blood component. RBCs were transfused in 269 patients (34%), primarily to address anemia or hemodynamic instability, at a mean pre\u2010transfusion hemoglobin of 7.5\u2009\u00b1\u20091.4\u2009g\/dL, consistent with restrictive practice. Platelets were given to 78 patients (10%) for prophylaxis or active bleeding at a median count of 26\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \u2009cells\/L (interquartile range 16\u201351\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \u2009cells\/L). Plasma was administered to 108 patients (14%), half for bleeding control and half for non\u2010bleeding indications.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This largest international snapshot of septic ICU transfusion practices confirms adherence to restrictive RBC thresholds but reveals substantial variability in platelet and plasma use. These findings underscore the need for targeted trials to refine transfusion guidelines in sepsis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.18445","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T08:49:37Z","timestamp":1761122977000},"page":"2272-2285","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Global transfusion practices in septic patients in the intensive care unit: insights from the\n                    <scp>InPUT<\/scp>\n                    \u2010study sub\u2010analysis"],"prefix":"10.1111","volume":"65","author":[{"given":"Vincent C.","family":"Kurucz","sequence":"first","affiliation":[{"name":"Department of Intensive Care Amsterdam University Medical Centers  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew W. J.","family":"Flint","sequence":"additional","affiliation":[{"name":"Transfusion Research Unit, School of Public Health and Preventive Medicine Monash University  Melbourne Australia"},{"name":"The Australian and New Zealand Intensive Care Research Centre (ANZIC\u2010RC), School of Public Health and Preventive Medicine Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Poole","sequence":"additional","affiliation":[{"name":"The Australian and New Zealand Intensive Care Research Centre (ANZIC\u2010RC), School of Public Health and Preventive Medicine Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3738-0397","authenticated-orcid":false,"given":"Merijn C.","family":"Reuland","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Amsterdam University Medical Centers  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"van den Oord","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Amsterdam University Medical Centers  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline M.","family":"Schaap","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Amsterdam University Medical Centers  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Bakker","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Adults Erasmus MC University Medical Centers  Rotterdam The Netherlands"},{"name":"Department of Pulmonary and Critical Care New York University  New York New York USA"},{"name":"Department of Pulmonary and Critical Care Columbia University  New York New York USA"},{"name":"Department of Intensive Care Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Cecconi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care IRCCS Humanitas Research Hospital  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0014-8879","authenticated-orcid":false,"given":"Aarne","family":"Feldheiser","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy EvangKliniken Essen\u2010Mitte, Huyssens\u2010Stiftung\/Knappschaft  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Meier","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Kepler University Clinic, Kepler University  Linz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9698-7185","authenticated-orcid":false,"given":"Zoe","family":"McQuilten","sequence":"additional","affiliation":[{"name":"Transfusion Research Unit, School of Public Health and Preventive Medicine Monash University  Melbourne Australia"},{"name":"The Australian and New Zealand Intensive Care Research Centre (ANZIC\u2010RC), School of Public Health and Preventive Medicine Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcella C. A.","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Amsterdam University Medical Centers  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanne","family":"de Bruin","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Amsterdam University Medical Centers  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas W. L.","family":"Scheeren","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarikul","family":"Hamid","sequence":"additional","affiliation":[{"name":"Department of Critical Care Asgar Ali Hospital  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Aubron","sequence":"additional","affiliation":[{"name":"M\u00e9decine Intensive R\u00e9animation, CHU de Brest Universit\u00e9 de Bretagne Occidentale  Brest France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u00ebl","family":"Piagnerelli","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, CHU Charleroi Marie Curie Universit\u00e9 Libre de Brussels  Charleroi 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