{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T09:06:24Z","timestamp":1789549584357,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:00:00Z","timestamp":1760832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:00:00Z","timestamp":1760832000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Rh immune globulin (RhIG) is used to prevent D alloimmunization and reduce the risk of hemolytic disease of the fetus and newborn (HDFN). Its use has been expanded to include immunoprophylaxis after D\u2010incompatible transfusions. In the United States, a protracted RhIG shortage began in 2023. The AABB (Association for the Advancement of Blood &amp; Biotherapies) Clinical Hemotherapy Subsection created a survey to assess RhIG usage patterns during this shortage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A survey was developed and electronically distributed to AABB\u2010accredited institutions. The number of responses was tallied. Frequencies were calculated, and free text comments were categorized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 112 responses (13.7%) were received from all regions of the United States. While 6.2% (6\/97) of respondents noticed increased RhIG usage, 70.0% (56\/80) experienced a shortage of RhIG. The most common indication reported for RhIG use was D\u2010negative pregnant patients carrying a D\u2010unknown or D\u2010positive fetus\/neonate. Some respondents also permitted RhIG use in D\u2010negative adult males and females outside of childbearing age following D\u2010incompatible transfusion. The most common institutional responses to the shortage were to: formally monitor RhIG inventory (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200937), add (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200934)\/switch (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200924) manufacturers, and redistribute RhIG between facilities (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200922). Few respondents (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20097) limited or discontinued RhIG use in non\u2010obstetric patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>While the majority of survey respondents were affected by the RhIG shortage, transfusion services still allowed RhIG to be issued outside of obstetric care. Given that RhIG is a limited resource and its intended goal is to reduce anti\u2010D HDFN, more effective management of RhIG utilization is needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.18465","type":"journal-article","created":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T17:23:28Z","timestamp":1760894608000},"page":"2286-2292","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A survey on the use of Rh immune globulin during a nationwide shortage"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2579-8640","authenticated-orcid":false,"given":"Kerry","family":"O'Brien","sequence":"first","affiliation":[{"name":"Department of Pathology Beth Israel Deaconess Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Abels","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Yale University Medical Center  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Bakhtary","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4572-0290","authenticated-orcid":false,"given":"Melissa","family":"George","sequence":"additional","affiliation":[{"name":"Department of Pathology Penn State Health Milton S. Hershey Medical Center  Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9101-9326","authenticated-orcid":false,"given":"Laura","family":"Stephens","sequence":"additional","affiliation":[{"name":"Department of Pathology University of California San Diego  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2292-3167","authenticated-orcid":false,"given":"Wen","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0041-1132.2003.00632.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12099"},{"key":"e_1_2_9_4_1","unstructured":"Rh(D) immune globulin (human). [cited 2025 Sep 29]. Available from:https:\/\/www.rhogam.com\/pdfs\/RhoGAM%20Prescribing%20Information.pdf"},{"key":"e_1_2_9_5_1","unstructured":"HyperRHO\u00ae S\/D Full Dose. [cited 2025 Sep 29]. Available from:https:\/\/grifolsug-pi.com\/inserts\/hyperrho-fd.pdf."},{"key":"e_1_2_9_6_1","unstructured":"WinRho highlights of prescribing information. [cited 2025 Sep 29]. Available from:https:\/\/winrho.com\/pdfs\/kamada_winrho-uspi.pdf."},{"key":"e_1_2_9_7_1","unstructured":"Highlights of prescribing information. [cited 2025 Sep 30]. Available from:https:\/\/labeling.cslbehring.com\/PI\/US\/Rhophylac\/EN\/Rhophylac-Prescribing-Information.pdf"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1997.tb126698.x"},{"key":"e_1_2_9_9_1","volume-title":"CBER\u2010regulated products: current shortages"},{"key":"e_1_2_9_10_1","unstructured":"Association Bulletin #24\u201002\u2014use of Rh immune globulin and considerations in the setting of supply shortages and limited availability. Available at:https:\/\/www.aabb.org\/docs\/default\u2010source\/default\u2010document\u2010library\/resources\/association\u2010bulletins\/ab24\u201002.pdf?sfvrsn=73ea486_6"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002232"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2024.02.288"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2022.07.002"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogc.2017.11.007"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12091"},{"key":"e_1_2_9_16_1","volume-title":"Guidelines for the use of Rh(D) immunoglobulin (anti\u2010D) in obstetrics (C\u2010Obs 6)","author":"The Royal Australian and New Zealand College of Obstetricians and Gynaecologists (RANZCOG)","year":"2021"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13158"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2000.02414.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2002.00074.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17348"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.11.019"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-11-4303"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.8.2523"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e318142ac5f"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17812"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.22043"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0000000000001011"},{"key":"e_1_2_9_28_1","unstructured":"Strengthening supply chain of anti\u2010D immunoglobulins. [cited 2025 Jul 30]. Available from:https:\/\/www.ema.europa.eu\/en\/news\/strengthening-supply-chain-anti-d-immunoglobulins"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.18465","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/trf.18465","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.18465","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T14:27:43Z","timestamp":1774276063000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.18465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,19]]},"references-count":27,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/trf.18465"],"URL":"https:\/\/doi.org\/10.1111\/trf.18465","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,19]]},"assertion":[{"value":"2025-08-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}