{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T06:06:58Z","timestamp":1779170818932,"version":"3.51.4"},"reference-count":58,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T00:00:00Z","timestamp":1763251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T00:00:00Z","timestamp":1763251200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100012114","name":"Defence Research and Development Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012114","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dried plasma offers a practical alternative for remote damage control resuscitation, providing hemostatic support and volume replacement. The Arctic presents challenges that necessitate the need for blood\u2010based resuscitation to extend the \u201cgolden hour.\u201d To address this, we evaluated the hemostatic and thermal stability of dried plasma following exposure during military Arctic operations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design and Methods<\/jats:title>\n                    <jats:p>OctaplasLG powder kits were deployed with Canadian Armed Forces medical providers during three Arctic operations. Dried plasma was subjected to substantial temperature fluctuations (\u221235.2 to 26.5\u00b0C) and multiple freeze\u2013thaw cycles. Upon return, dried plasma was reconstituted and evaluated using hemostatic\/coagulation panels and differential scanning calorimetry (DSC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Arctic\u2010exposed dried plasma retained visual integrity and protein concentration consistent with controls. Hemostatic function, including prothrombin time, activated partial thromboplastin time, fibrinogen, D\u2010dimer, factor V, factor VIII, plasminogen, antithrombin III, protein C, ADAMTS13, and viscoelastic profiles remained within normal ranges, with protein S activity below the lower limit. However, von Willebrand factor antigen levels were elevated in both dried plasma groups, though distribution remained normal and unlikely to be clinically significant for resuscitation. DSC thermograms revealed five characteristic thermal transitions consistent with controls, indicating preserved structural integrity. Enthalpy analysis demonstrated a strong correlation with fibrinogen concentration, suggesting its role in plasma stability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Dried plasma retains its hemostatic and thermal stability following Arctic deployment, supporting remote damage control resuscitation in the absence of whole blood. Nonetheless, field implementation is challenged by the propensity of the diluent to freeze and the logistical requirement for warmed infusion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.70003","type":"journal-article","created":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T14:14:42Z","timestamp":1763302482000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dried plasma retains hemostatic function and thermal stability during Arctic military operations"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3303-5966","authenticated-orcid":false,"given":"Kanwal","family":"Singh","sequence":"first","affiliation":[{"name":"Defence Research and Development Canada Toronto Research Centre  Toronto Ontario Canada"},{"name":"Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, Trauma and Acute Care Surgery St. Michael's Hospital  Toronto Ontario Canada"},{"name":"Royal Canadian Medical Services Department of National Defence  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5580-1273","authenticated-orcid":false,"given":"Aron A.","family":"Shoara","sequence":"additional","affiliation":[{"name":"Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, Trauma and Acute Care Surgery St. Michael's Hospital  Toronto Ontario Canada"},{"name":"Royal Canadian Medical Services Department of National Defence  Ottawa Ontario Canada"},{"name":"Centre for Innovation Canadian Blood Services  Toronto Ontario Canada"},{"name":"Department of Surgery, Temerty Faculty of Medicine University of Toronto  Toronto Ontario Canada"},{"name":"D\u00e9partement de Chimie Universit\u00e9 de Sherbrooke  Sherbrooke Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5276-9573","authenticated-orcid":false,"given":"Henry T.","family":"Peng","sequence":"additional","affiliation":[{"name":"Defence Research and Development Canada Toronto Research Centre  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5461-3354","authenticated-orcid":false,"given":"Viktor","family":"Prifti","sequence":"additional","affiliation":[{"name":"Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, Trauma and Acute Care Surgery St. Michael's Hospital  Toronto Ontario Canada"},{"name":"Department of Surgery, Temerty Faculty of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katy","family":"Moes","sequence":"additional","affiliation":[{"name":"Defence Research and Development Canada Toronto Research Centre  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cerys","family":"McGuinness","sequence":"additional","affiliation":[{"name":"Defence Research and Development Canada Toronto Research Centre  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tristan","family":"Bonnici","sequence":"additional","affiliation":[{"name":"Defence Research and Development Canada Toronto Research Centre  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Shiu","sequence":"additional","affiliation":[{"name":"Defence Research and Development Canada Toronto Research Centre  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0387-9711","authenticated-orcid":false,"given":"Sushmaa Chandralekha","family":"Selvakumar","sequence":"additional","affiliation":[{"name":"Thrombosis and Atherosclerosis Research Institute McMaster University and Hamilton Health Sciences  Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5796-958X","authenticated-orcid":false,"given":"Peter","family":"Andrisani","sequence":"additional","affiliation":[{"name":"Thrombosis and Atherosclerosis Research Institute McMaster University and Hamilton Health Sciences  Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5584-3844","authenticated-orcid":false,"given":"Pierre\u2010Marc","family":"Dion","sequence":"additional","affiliation":[{"name":"Royal Canadian Medical Services Department of National Defence  Ottawa Ontario Canada"},{"name":"Department of Family Medicine McGill University  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damien","family":"Miller","sequence":"additional","affiliation":[{"name":"Royal Canadian Medical Services Department of National Defence  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6984-1812","authenticated-orcid":false,"given":"Sebastian","family":"Vuong","sequence":"additional","affiliation":[{"name":"Royal Canadian Medical Services Department of National Defence  Ottawa Ontario Canada"},{"name":"Depatment of Anesthesiology McMaster University and Hamilton Health Sciences  Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7979-7603","authenticated-orcid":false,"given":"Colin A.","family":"Kretz","sequence":"additional","affiliation":[{"name":"Thrombosis and Atherosclerosis Research Institute McMaster University and Hamilton Health Sciences  Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7023-3856","authenticated-orcid":false,"given":"Philip J.","family":"Wallace","sequence":"additional","affiliation":[{"name":"Defence Research and Development Canada Toronto Research Centre  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2300-0620","authenticated-orcid":false,"given":"Shawn G.","family":"Rhind","sequence":"additional","affiliation":[{"name":"Defence Research and Development Canada Toronto Research Centre  Toronto Ontario Canada"},{"name":"Faculty of Kinesiology &amp; Physical Education University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4935-9861","authenticated-orcid":false,"given":"Wendy","family":"Sullivan\u2010Kwantes","sequence":"additional","affiliation":[{"name":"Defence Research and Development Canada Toronto Research Centre  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4943-9415","authenticated-orcid":false,"given":"Andrew N.","family":"Beckett","sequence":"additional","affiliation":[{"name":"Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, Trauma and Acute Care Surgery St. Michael's Hospital  Toronto Ontario Canada"},{"name":"Royal Canadian Medical Services Department of National Defence  Ottawa Ontario Canada"},{"name":"Centre for Innovation Canadian Blood Services  Toronto Ontario Canada"},{"name":"Department of Surgery, Temerty Faculty of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,16]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e3182755dcc"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000002610"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000004103"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TA.0000064510.10435.DD"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1503\/cjs.001815"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/milmed\/usy112"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12667"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12245-019-0253-8"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000003324"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00068-022-02050-6"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e3181271ba3"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.18124"},{"issue":"2","key":"e_1_2_12_14_1","doi-asserted-by":"crossref","DOI":"10.1136\/tsaco-2025-001828","article-title":"Bridging the gap: whole blood and plasma in prehospital hemorrhagic shock resuscitation","volume":"10","author":"Matthew J","year":"2025","journal-title":"Trauma Surg Acute Care Open"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000004089"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/life14050619"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2023.150807"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.19298"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17139"},{"key":"e_1_2_12_20_1","unstructured":"Department of National Defence.Our north strong and free: a renewed vision for Canada's defence [Internet]. Department of National Defence. Accessed August 01 2025. Seminars in Nephrology. Available from:https:\/\/www.canada.ca\/en\/department\u2010national\u2010defence\/corporate\/reports\u2010publications\/north\u2010strong\u2010free\u20102024\/canada\u2010time\u2010global\u2010uncertainty.html"},{"key":"e_1_2_12_21_1","unstructured":"GosnellR JensenB.NATO and the Arctic. Washington DC: CSIS Center for Strategic and International Studies.2024."},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2019.5085"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.15097"},{"key":"e_1_2_12_24_1","volume-title":"Octaplas LG powder for solution for infusion: making a vital contribution to the health of Canadian soldiers","author":"Octapharma","year":"2024"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2024.111771"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1503\/cjs.006924"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21739"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtha.2023.03.021"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/life14020172"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2025.108392"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2017.08.010"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.107.119453"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.1c03781"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2012.08.001"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2007.09.004"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021004404"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-06-528406"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13798"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2008.02845.x"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15873"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0000000000001089"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15667"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15856"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830360104"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13203219"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13491"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2011.06.015"},{"key":"e_1_2_12_49_1","first-page":"167","volume-title":"Advances in protein chemistry","author":"Privalov PL","year":"1979"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867054546564"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/bip.1978.360170212"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpc.2010.09.007"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0269600"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.906768"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2004.08.003"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16756"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16319"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1080\/22423982.2023.2196047"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.250648"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.70003","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/trf.70003","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.70003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T05:21:41Z","timestamp":1779168101000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.70003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,16]]},"references-count":58,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/trf.70003"],"URL":"https:\/\/doi.org\/10.1111\/trf.70003","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,16]]},"assertion":[{"value":"2025-08-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}