{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:11:18Z","timestamp":1789564278420,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Little is known about how platelet shortages impact patient care and outcomes. In the summer of 2024, a ransomware event substantially impacted blood product processing capacity in South Florida, creating a natural experiment to evaluate such a shortage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design and Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective study of platelet test results\u2014categorized as &lt;10,000\/\u03bcL (universal transfusion recommendation), 10,000\u201349,000\/\u03bcL (equivocal transfusion indication), and \u226550,000\/\u03bcL (transfusion rarely indicated)\u2014from adults hospitalized at the University of Miami Hospital and Clinics during (July 29\u2013August 4) versus pre\u2010 (July 1\u2013July 28) or post\u2010 (August 5\u2013September 1) shortage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 26,457 platelet results\u201446.3% pre\u2010, 11.3% during, 42.3% post\u2010shortage\u2014from 3605 hospitalizations. Platelet counts of 10,000\u201349,000\/\u03bcL in the pre\u2010 (odds ratio [95% confidence interval]: 3.05 [1.43, 6.51]) and post\u2010 (2.89 [1.27, 6.60]) periods were more often followed by transfusions within 6\u2009h than during the shortage. No difference was observed following platelet counts &lt;10,000\/\u03bcL or \u226550,000\/\u03bcL. We found no statistically significant difference in hospital mortality or hemorrhage across periods. However, during the shortage mortality was numerically higher (20.0% vs. pre: 15.2%, post: 18.3%) and hemorrhage was lower (0.0% vs. pre: 19.0%, post: 18.3%) for hospitalizations with nadir platelet counts of 10,000\u201349,000\/\u03bcL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Shortage conditions were associated with fewer platelet transfusions following counts of 10,000\u201349,000\/\u03bcL without significant patient harm. These findings suggest that, with sufficient resources, it is possible to change practice quickly and that guideline\u2010concordant care for platelet transfusions may reduce waste while maintaining quality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.70055","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T17:26:43Z","timestamp":1767115603000},"page":"334-341","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of a Platelet Shortage with process and clinical outcomes"],"prefix":"10.1111","volume":"66","author":[{"given":"Hayley B.","family":"Gershengorn","sequence":"first","affiliation":[{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine University of Miami Miller School of Medicine  Miami Florida USA"},{"name":"Division of Critical Care Medicine, Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyun","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Laboratory Medicine, Department of Pathology and Laboratory Medicine University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Carlotto","sequence":"additional","affiliation":[{"name":"Care Transformation University of Miami Hospital and Clinics  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samira","family":"Patel","sequence":"additional","affiliation":[{"name":"Care Transformation University of Miami Hospital and Clinics  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M.","family":"Mallow","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipen J.","family":"Parekh","sequence":"additional","affiliation":[{"name":"Department of Urology University of Miami Miller School of Medicine  Miami Florida USA"},{"name":"UHealth Leadership University of Miami Hospital and Clinics  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kymberlee J.","family":"Manni","sequence":"additional","affiliation":[{"name":"UHealth Leadership University of Miami Hospital and Clinics  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanira","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine University of Miami Miller School of Medicine  Miami Florida USA"},{"name":"UHealth Leadership University of Miami Hospital and Clinics  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1934"},{"key":"e_1_2_9_3_1","unstructured":"Red Cross declares emergency blood shortage calls for donations during National Blood Donor Month [monograph on the internet].American Red Cross.2024. Available from:https:\/\/www.redcross.org\/about\u2010us\/news\u2010and\u2010events\/press\u2010release\/2024\/red\u2010cross\u2010declares\u2010emergency\u2010blood\u2010shortage\u2010calls\u2010for\u2010donations\u2010during\u2010national\u2010blood\u2010donor\u2010month.html."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.2841"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/OP.24.00394"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2024.0581"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27479"},{"key":"e_1_2_9_8_1","unstructured":"OneBlood Returns to Normal Distribution of Blood to Hospitals Following Ransomware Event [monograph on the internet].OneBlood.2024. Available from:https:\/\/www.oneblood.org\/media\/press\u2010releases\/oneblood\u2010returns\u2010to\u2010normal\u2010distribution\u2010of\u2010blood\u2010to\u2010hospitals\u2010following\u2010ransomware\u2010event.html."},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2019.07.021"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201808-564PS"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199801000-00004"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01709751"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14423"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2025.7529"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/1062860616636221"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2010.02358.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.5858\/2008-132-1321-PCWPUC"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.70055","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/trf.70055","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.70055","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T12:58:47Z","timestamp":1789563527000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.70055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,30]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/trf.70055"],"URL":"https:\/\/doi.org\/10.1111\/trf.70055","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,30]]},"assertion":[{"value":"2025-08-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}