{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:52:01Z","timestamp":1790628721720,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neonates with hemolytic disease of the fetus and newborn (HDFN) may require exchange transfusions (ET) for severe hyperbilirubinemia. We evaluated if ET in neonates with HDFN was associated with the maximum maternal titer and antibody\u2010dependent cellular cytotoxicity (ADCC) and we determined the change in the number of hospitals performing ET in the Netherlands.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design and Methods<\/jats:title>\n                    <jats:p>National, multicenter analysis of neonates for whom an ET product (c.q. reconstituted whole blood) was ordered between Jan 1, 2011 and Dec 31, 2021 in the Netherlands. To quantify the ET risk, we retrieved maternal serological test results for cases with an ET for non\u2010ABO HDFN (numerator) and from all alloimmunized pregnancies (denominator). Current and past ET practices were assessed with a questionnaire.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010four participating centers ordered 1564 of the total 1824 (84%) ET products in the 11\u2010year study period. We identified 627 patients for whom a product was ordered, among these 111 (17.7%) received ET for HDFN. We found increasing ET rates in D\u2010mediated HDFN from 0.9% (5\/558) when maximum titers were\u2009\u2264\u20091:32 to 19.6% (18\/92) if titers were 1:512. Rates of ET increased from 1.1% (9\/823) if the maximum ADCC was &lt;50% to 18.7% (72\/386) if the ADCC was \u226550%. The number of hospitals practicing ET nowadays was 36.7% (18\/49), a 56.1% decline compared to before 2010 (41\/49).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Antenatal serological tests may aid caregivers to anticipate the need for ET in neonates with non\u2010ABO HDFN. We found a substantially altered treatment landscape with considerably fewer Dutch hospitals performing ET.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.70056","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T17:25:46Z","timestamp":1767115546000},"page":"296-305","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Antenatal risk estimation for exchange transfusions in neonates with hemolytic disease of the fetus and newborn in a changing treatment landscape: A multicenter, retrospective cohort study"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4820-143X","authenticated-orcid":false,"given":"Derek P.","family":"de Winter","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology, Willem\u2010Alexander Children's Hospital Leiden University Medical Center  Leiden The Netherlands"},{"name":"Division of Fetal Medicine, Department of Obstetrics Leiden University Medical Center  Leiden The Netherlands"},{"name":"Department of Immunohematology Diagnostic Services Sanquin Diagnostic Services  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7044-0525","authenticated-orcid":false,"given":"Masja","family":"de Haas","sequence":"additional","affiliation":[{"name":"Division of Fetal Medicine, Department of Obstetrics Leiden University Medical Center  Leiden The Netherlands"},{"name":"Department of Haematology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8159-7501","authenticated-orcid":false,"given":"Christian V.","family":"Hulzebos","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology, Beatrix Children's Hospital University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u00ebl V.","family":"Lukens","sequence":"additional","affiliation":[{"name":"Laboratory for Blood Transfusion, Department of Laboratory Medicine University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra A.","family":"Prins","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Emma Children's Hospital Amsterdam University Medical Center  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4907-6466","authenticated-orcid":false,"given":"Jasper V.","family":"Been","sequence":"additional","affiliation":[{"name":"Department of Neonatal and Pediatric Intensive Care, Division of Neonatology, Erasmus MC Sophia Children's Hospital University Medical Center Rotterdam  Rotterdam The Netherlands"},{"name":"Department of Obstetrics and Gynecology, Erasmus MC Sophia Children's Hospital University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther J.","family":"d'Haens","sequence":"additional","affiliation":[{"name":"Department of Neonatology Isala  Zwolle The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dani\u00ebl C.","family":"Vijlbrief","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Wilhemina Children's Hospital, UMC Utrecht Utrecht University  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine L. A. G.","family":"Vrancken","sequence":"additional","affiliation":[{"name":"Department of Neonatology Radboud UMC, Amalia Children's Hospital  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda M. P.","family":"Trompenaars","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology, MosaKids Children's Hospital Maastricht University Medical Center  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huib","family":"Ceelie","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry Franciscus Gasthuis &amp; Vlietland  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lieke M. J.","family":"van Zogchel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Jeroen Bosch Hospital  's\u2010Hertogenbosch The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemiek M. C. P.","family":"Joosen","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry M\u00e1xima Medical Center  Veldhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens B.","family":"Meijssen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Meander Medical Center  Amersfoort The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. L. A. M.","family":"van Hillegersberg","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Sint Antonius Ziekenhuis  The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janneke C.","family":"Zant","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry Northwest Clinics  Alkmaar and Den Helder The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maaike C.","family":"van Rossem","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Rijnstate  Arnhem The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"van Beek","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Amphia Hospital  Breda The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helene G.","family":"Stas","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Maasstad Ziekenhuis  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare E.","family":"Counsilman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Flevoziekenhuis  Almere The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. R.","family":"Knol","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Medisch Centrum Leeuwarden  Leeuwarden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. A. M.","family":"Schiering","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Spaarne Gasthuis  Haarlem\/Hoofddorp The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerdina H.","family":"Dubbink\u2010Verheij","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Groene Hart Ziekenhuis  Gouda The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9343-9957","authenticated-orcid":false,"given":"E. J. T.","family":"Verweij","sequence":"additional","affiliation":[{"name":"Division of Fetal Medicine, Department of Obstetrics Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3513-5066","authenticated-orcid":false,"given":"Enrico","family":"Lopriore","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology, Willem\u2010Alexander Children's Hospital Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the WISE investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-022-04724-0"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474086.2022.2138853"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2015.1.146"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12265"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.41.6.1047"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13090"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-2910"},{"issue":"6","key":"e_1_2_11_9_1","first-page":"384","article-title":"Exchange transfusion trends and risk factors for extreme neonatal hyperbilirubinemia over 10\u2009years in shiraz, Iran","volume":"49","author":"Hemmati F","year":"2024","journal-title":"Iran J Med Sci"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-020-0642-0"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12288-015-0534-1"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.112970"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15631"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.114.1.297"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2024.114225"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.01.028"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2022-058859"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-020-04312-3"},{"issue":"8","key":"e_1_2_11_19_1","article-title":"Exchange transfusion simulation models: a technical report","volume":"11","author":"Rosen O","year":"2019","journal-title":"Cureus"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.70056","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/trf.70056","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.70056","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T12:58:55Z","timestamp":1789563535000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.70056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,30]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/trf.70056"],"URL":"https:\/\/doi.org\/10.1111\/trf.70056","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,30]]},"assertion":[{"value":"2024-10-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}