{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:11:20Z","timestamp":1789564280859,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T00:00:00Z","timestamp":1766793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T00:00:00Z","timestamp":1766793600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["P01 HL149626"],"award-info":[{"award-number":["P01 HL149626"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Reports on the safety and efficacy of combination heparin and citrate anticoagulation with cell therapy collections in adults are limited. There are no reports on the use of this combination in healthy allogeneic adult donors undergoing cell therapy collection. This retrospective analysis is the first study to examine its safety and efficacy in cell therapy collections of healthy adult allogeneic donors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design and Methods<\/jats:title>\n                    <jats:p>The heparin infusion rate and adverse event profile for 90 cell therapy collections using 6\u2009units heparin per mL of citrate anticoagulation were examined. In 12 consecutive large volume collections, activated partial thromboplastin time (aPTT), anti\u2010Xa levels, and target cell collection efficiencies were also analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Heparin infusion rates approximated the rate recommended for acute venous thrombosis. There were no adverse events related to heparin. There was a good correlation between aPTT and anti\u2010Xa levels, but no patient had supratherapeutic and only 3 had therapeutic anti\u2010Xa levels. An inverse correlation was found between the anti\u2010Xa level and platelet loss. Collection efficiencies of mononuclear cell types were increased compared to citrate\u2010only collections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Heparin\/citrate anticoagulation was safe, with lower heparin infusion rates, anti\u2010Xa levels, and less prolonged aPTT than those observed in autologous adult donors. The good correlation between aPTT and anti\u2010Xa levels suggests that aPTT levels can be used to estimate anti\u2010Xa levels. Collection efficiencies of mononuclear cell types on heparin\/ACD\u2010A anticoagulation should be further explored.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.70057","type":"journal-article","created":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T19:17:08Z","timestamp":1766863028000},"page":"385-392","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Safety and efficacy of combined heparin\/citrate anticoagulation for cell therapy collections in healthy adult allogeneic donors"],"prefix":"10.1111","volume":"66","author":[{"given":"Jiahao","family":"Zhang","sequence":"first","affiliation":[{"name":"Lindsley F. Kimball Research Institute New York Blood Center  Rye New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demi Minlun","family":"Wu","sequence":"additional","affiliation":[{"name":"Lindsley F. 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