{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T15:07:03Z","timestamp":1779116823073,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000014","name":"Canadian Blood Services","doi-asserted-by":"publisher","award":["IG2019\u2010SN"],"award-info":[{"award-number":["IG2019\u2010SN"]}],"id":[{"id":"10.13039\/501100000014","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Immunomodulatory consequences of transfusion, known as transfusion\u2010related immune modulation (TRIM), impact patients but are not captured by hemovigilance systems. This study's objective is to explore TRIM impacts of production changes made by the blood supplier.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included all transfused and non\u2010transfused adult inpatients from 2002 to 2022 in Hamilton, Canada. Non\u2010transfused patients served as controls to identify confounding temporal trends. We captured data from the Transfusion Research Utilization Surveillance and Tracking (TRUST) database and recorded TRIM outcomes including: sepsis, respiratory failure, venous thrombosis, organ dysfunction and in\u2010hospital mortality using International Classification of Diseases codes, Canadian Classification of Health Interventions codes, and laboratory parameters, where applicable. The blood supplier provided data on production changes and quality control assessments. We used time series trend graphs to summarize aggregate data and the rolling window E\u2010Divisive with Medians to detect change. A transparent and replicable point system approach identified changes in blood production most likely to have TRIM impacts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A cohort of 568,991 non\u2010transfused and 102,446 transfused hospital admissions were included. We generated 40 time series TRIM trend graphs for transfused (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200935) and non\u2010transfused patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20095). The blood supplier independently identified 12 key product policy, collection, or production changes. Consolidation of production in Ontario and introduction of buffy coat manufacturing were identified as having high TRIM impacts for patients transfused with any blood components.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Using a novel hypothesis generating data mining design, consolidation of blood production and buffy coat manufacturing are identified as changes with possible TRIM impacts among transfused hospitalized patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.70060","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T05:14:32Z","timestamp":1769836472000},"page":"579-589","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Novel method for trend change detection and hypothesis generation in hemovigilance: A transfusion\u2010related immunomodulation and blood production changes study"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7675-4058","authenticated-orcid":false,"given":"S.","family":"Ning","sequence":"first","affiliation":[{"name":"Michael G. DeGroote Centre for Transfusion Research, Department of Medicine McMaster University  Hamilton Ontario Canada"},{"name":"Department of Medicine McMaster University  Hamilton Ontario Canada"},{"name":"Department of Pathology and Molecular Medicine McMaster University  Hamilton Ontario Canada"},{"name":"Canadian Blood Services  Ancaster Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Li","sequence":"additional","affiliation":[{"name":"Michael G. DeGroote Centre for Transfusion Research, Department of Medicine McMaster University  Hamilton Ontario Canada"},{"name":"Department of Community Health Sciences University of Calgary  Calgary Alberta Canada"},{"name":"Department of Computing and Software McMaster University  Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Liu","sequence":"additional","affiliation":[{"name":"Michael G. DeGroote Centre for Transfusion Research, Department of Medicine McMaster University  Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Kim","sequence":"additional","affiliation":[{"name":"Michael G. DeGroote Centre for Transfusion Research, Department of Medicine McMaster University  Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1445-827X","authenticated-orcid":false,"given":"J. P.","family":"Acker","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Alberta  Edmonton Alberta Canada"},{"name":"Innovation and Portfolio Management Canadian Blood Services  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Arnold","sequence":"additional","affiliation":[{"name":"Michael G. DeGroote Centre for Transfusion Research, Department of Medicine McMaster University  Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Hadzi\u2010Tosev","sequence":"additional","affiliation":[{"name":"Michael G. DeGroote Centre for Transfusion Research, Department of Medicine McMaster University  Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Hillis","sequence":"additional","affiliation":[{"name":"Department of Oncology McMaster University  Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Kauffman","sequence":"additional","affiliation":[{"name":"Temerty Faculty of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. J.","family":"Lucier","sequence":"additional","affiliation":[{"name":"Michael G. DeGroote Centre for Transfusion Research, Department of Medicine McMaster University  Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. C.","family":"Liaw","sequence":"additional","affiliation":[{"name":"Department of Medicine McMaster University  Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Rochwerg","sequence":"additional","affiliation":[{"name":"Department of Medicine McMaster University  Hamilton Ontario Canada"},{"name":"Department of Health Research Methods, Evidence and Impact McMaster University  Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Syed","sequence":"additional","affiliation":[{"name":"Department of Anesthesia Halton Health Care  Oakville Ontario Canada"},{"name":"Department of Anesthesia McMaster University  Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Travis","sequence":"additional","affiliation":[{"name":"Michael G. 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