{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:40:25Z","timestamp":1792086025340,"version":"4.4.0"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH\u201012\u20101\u20100441"],"award-info":[{"award-number":["W81XWH\u201012\u20101\u20100441"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In this pilot trial, we tested the feasibility of conducting a randomized controlled trial in cardiac surgery patients using extended\u2010, 100% plasma\u2010, cold\u2010stored, and long\u2010distance\u2010shipped platelets (CSPs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design and Methods<\/jats:title>\n                    <jats:p>We conducted a single center, controlled, double\u2010blind pilot study in adult patients undergoing elective redo or complex cardiothoracic surgery. Patients were allocated in a week\u2010based block randomization scheme to receive either room temperature\u2010stored platelets (RTPs) or CSPs shipped from a Texas\u2010based blood center and stored between 10 and 14\u2009days. The primary outcome was defined as the feasibility of recruitment and accrual. Several other secondary endpoints were assessed. All platelet units were screened for aggregates using RTP release criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In a post\u2010hoc \u201cas treated\u201d analysis, 15 patients received\n                      <jats:styled-content style=\"fixed-case\">RTPs<\/jats:styled-content>\n                      , and 9 received\n                      <jats:styled-content style=\"fixed-case\">CSPs<\/jats:styled-content>\n                      (including 3 who received both). We found that most\n                      <jats:styled-content style=\"fixed-case\">CSPs<\/jats:styled-content>\n                      (58%) were not usable for transfusion due to the presence of aggregates. This resulted in an excess of subjects receiving\n                      <jats:styled-content style=\"fixed-case\">RTPs<\/jats:styled-content>\n                      ; consequently, the final nine transfused participants were allocated to receive\n                      <jats:styled-content style=\"fixed-case\">CSPs<\/jats:styled-content>\n                      without randomization. We accrued 0.7 evaluable subjects\/month of active enrollment, which was below our desired primary outcome feasibility target of \u22651.2. One death within 28\u2009days occurred in the\n                      <jats:styled-content style=\"fixed-case\">RTP<\/jats:styled-content>\n                      transfusion group, while none occurred in the\n                      <jats:styled-content style=\"fixed-case\">CSPs<\/jats:styled-content>\n                      group. In vitro testing yielded contradictory results.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Due to slow recruitment and the abundance of aggregates in CSPs, this pilot trial does not support the feasibility of the study protocol.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.70076","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T12:38:52Z","timestamp":1768221532000},"page":"555-567","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A pilot trial of long\u2010distance shipped, extended\u2010 and cold\u2010stored platelets in 100% plasma for cardiothoracic surgical bleeding"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2866-1674","authenticated-orcid":false,"given":"Moritz","family":"Stolla","sequence":"first","affiliation":[{"name":"Bloodworks Northwest Research Institute  Seattle Washington USA"},{"name":"Bloodworks Northwest Medical Services Division  Seattle Washington USA"},{"name":"Department of Medicine, Division of Hematology and Oncology University of Washington  Seattle Washington USA"},{"name":"Department of Laboratory Medicine and Pathology University of Washington  Seattle Washington USA"},{"name":"Clinical Research Division Fred Hutch Cancer Institute  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Lawrence","family":"Bailey","sequence":"additional","affiliation":[{"name":"Bloodworks Northwest Research Institute  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aastha","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Bloodworks Northwest Research Institute  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daire A.","family":"Byrne","sequence":"additional","affiliation":[{"name":"Bloodworks Northwest Research Institute  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Ting","sequence":"additional","affiliation":[{"name":"Stasys Medical Corporation  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Klotz","sequence":"additional","affiliation":[{"name":"Bloodworks Northwest Research Institute  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan N.","family":"Pulido","sequence":"additional","affiliation":[{"name":"Department of Critical Care, Division of Cardiac Anesthesiology, US Anesthesia Partners Swedish Medical Center, Cherry Hill Campus  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric J.","family":"Lehr","sequence":"additional","affiliation":[{"name":"Swedish Medical Center Swedish Cardiac Surgery  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Youssef","sequence":"additional","affiliation":[{"name":"Swedish Medical Center Swedish Cardiac Surgery  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josh","family":"Lawrence","sequence":"additional","affiliation":[{"name":"Stasys Medical Corporation  Seattle Washington 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