{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:06:09Z","timestamp":1790791569321,"version":"4.1.0"},"reference-count":63,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Fetal\/neonatal alloimmune thrombocytopenia (FNAIT) caused by antibodies to human platelet antigen (HPA)\u20101a in white HPA\u20101a\u2010negative mothers is the most frequent cause of intracranial hemorrhage (ICH) in otherwise healthy newborns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate the natural history of FNAIT and establish a biobank from HPA\u20101a\u2010negative alloimmunized and nonimmunized pregnancies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 24,259 pregnant women were recruited to the study during 2013\u20132017 and 24,236 were screened for HPA\u20101a. Anti\u2010HPA\u20101a antibodies were tested by Monoclonal Antibody Immobilization of Platelet Antigens (MAIPA) and some samples (MAIPA\u2010negative), with Luminex bead\u2010based immunoassay (PAKLx) if the neonate had thrombocytopenia and\/or ICH. HPA\u20101 genotyping of fathers, fetuses (from maternal plasma), and newborns was performed. Biological material was stored in biobanks in Norway and Poland.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 583\/24,236 (2.4%) HPA\u20101a\u2010negative women, samples were obtained from 529, of which 513 were examined during pregnancy. Anti\u2010HPA\u20101a antibodies were detected in 48\/529 (9.1%) women; whereof 34\/513 (6.6%) during pregnancy, either by prospective MAIPA (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200927) or in retrospect by PAKLx in MAIPA\u2010negatives (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20097). FNAIT was diagnosed in 11\/34 (32%) neonates from alloimmunized pregnancies: in 6\/11 cases by prospective MAIPA and in 5\/11 by retrospective PAKLx. There were no neonates with FNAIT\u2010associated ICH delivered by MAIPA\u2010positive women, but 3 ICH\/severe thrombocytopenia cases were diagnosed by PAKLx. Among nonimmunized HPA\u20101a\u2010negative women, 28 newborns had thrombocytopenia and 2 others had ICH.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Feasibility of HPA\u20101 antenatal screening was demonstrated, and a comprehensive biobank was established. The FNAIT detection rate was improved by retrospective diagnostics by PAKLx, including 3 newborns with ICH not identified by prospective MAIPA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.70080","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T11:19:19Z","timestamp":1768562359000},"page":"814-827","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>HPA<\/scp>\n                    \u20101a alloimmunization and pregnancy outcome in a Polish screening program:\n                    <scp>PREVFNAIT<\/scp>"],"prefix":"10.1111","volume":"66","author":[{"given":"Guz","family":"Katarzyna","sequence":"first","affiliation":[{"name":"Department of Hematological and Transfusion Immunology Institute of Hematology and Transfusion Medicine  Warsaw 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