{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:31:11Z","timestamp":1790425871771,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T00:00:00Z","timestamp":1768694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T00:00:00Z","timestamp":1768694400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The deferral period for men who have sex with men (MSM) in the US decreased over time from indefinite deferral to 12 to 3\u2009months. In 2023, the US Food and Drug Administration permitted individual donor assessment (IDA), shifting from categorical exclusions to risk behavior\u2010based screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Trends in HIV risk\u2010based behavior deferrals in a large US collector over similar periods with indefinite MSM, 12\u2010month, and 3\u2010month deferrals versus IDA were analyzed. Rates of confirmed HIV, hepatitis B virus (HBV), and syphilis testing during corresponding pre\u2010 and post\u2010IDA periods are reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among males, a significant decrease in HIV risk\u2010based behavior deferrals occurred from indefinite deferral (0.150%) to 12\u2010month (0.114%) to 3\u2010month (0.085%) periods, to IDA (0.067%). For females, MSM contact deferrals significantly decreased from 12\u2010month deferral periods (0.015\u20130.033%) to 3\u2010month deferral periods (0.007%); post\u2010IDA, rates significantly increased to 0.049%. IDA increased overall deferrals from 0.04% to 0.06% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) compared to the 3\u2010month deferral period. Higher deferrals were seen in males (adjusted odds ratio [aOR]\u2009=\u20091.45 [95% CI\u2009=\u20091.24\u20131.69]), first\u2010time versus active donors (aOR\u2009\u2009=\u20092.54 [2.12\u20133.03]), and at ages 19\u201322 (aOR\u2009=\u20092.73 [2.12\u20133.52]) compared to 30\u2010 and 39\u2010year\u2010olds. IDA implementation did not increase the rates of confirmed HIV, HBV, or active syphilis; however, rates of RPR\u2010negative confirmed syphilis reactivity rose significantly post\u2010IDA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Transition from indefinite MSM deferral to 12 and then 3\u2009months significantly decreased deferral rates. Rates rose in female but not male donors with IDA. IDA implementation did not result in higher rates of confirmed HIV, HBV, or active syphilis. An increase in remote\/treated syphilis may be confounded by broader epidemiological trends rather than IDA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.70085","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T07:30:38Z","timestamp":1768807838000},"page":"534-542","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Individual donor assessment in the United States: Impact on deferral and infectious disease marker rates"],"prefix":"10.1111","volume":"66","author":[{"given":"Ruchika","family":"Goel","sequence":"first","affiliation":[{"name":"Vitalant, Medical Affairs  Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjorie","family":"Bravo","sequence":"additional","affiliation":[{"name":"Vitalant, Medical Affairs  Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Townsend","sequence":"additional","affiliation":[{"name":"Vitalant, Medical Affairs  Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"Hopkins","sequence":"additional","affiliation":[{"name":"Vitalant, Medical Affairs  Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8754-047X","authenticated-orcid":false,"given":"Ralph","family":"Vassallo","sequence":"additional","affiliation":[{"name":"Vitalant, Medical Affairs  Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,18]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"US Food and Drug Administration.Guidance for INDUSTRY: recommendations for evaluating donor eligibility using individual risk\u2010based questions to reduce the risk of human immunodeficiency virus transmission by blood and blood products.2023. [Monograph on the internet]. Available from:https:\/\/www.fda.gov\/regulatory\u2010information\/search\u2010fda\u2010guidancedocuments\/recommendations\u2010evaluating\u2010donor\u2010eligibility\u2010using\u2010individual\u2010risk\u2010based\u2010questions\u2010reduce\u2010risk\u2010human"},{"key":"e_1_2_8_3_1","first-page":"137","article-title":"Human immunodeficiency virus infection in transfusion recipients and their family members","volume":"36","author":"Centers for Disease Control (CDC)","year":"1987","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_8_4_1","first-page":"652","article-title":"Possible transfusion\u2010associated acquired immune deficiency syndrome (AIDS) \u2013 California","volume":"31","author":"Centers for Disease Control (CDC)","year":"1982","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2020.02.001"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12225"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.18195"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16250"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13632"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17515"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17916"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17707"},{"key":"e_1_2_8_13_1","article-title":"Trends in incidence of syphilis among US adults from January 2017 to October 2024","author":"Do D","year":"2025","journal-title":"Am J Prev Med"},{"key":"e_1_2_8_14_1","first-page":"547","article-title":"Update: revised public health service definition of persons who should refrain from donating blood and plasma\u2014United States","volume":"34","author":"Centers for Disease Control (CDC)","year":"1985","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13726"},{"key":"e_1_2_8_16_1","unstructured":"France to lift blood donation ban for gay men who have had recent sex.2022. [Monograph on the internet]. Available from:https:\/\/www.connexionfrance.com\/news\/france\u2010to\u2010lift\u2010blood\u2010donation\u2010ban\u2010for\u2010gay\u2010men\u2010who\u2010have\u2010had\u2010recent\u2010sex"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13435"},{"key":"e_1_2_8_18_1","unstructured":"NHS.Blood donor selection policy: more people now able to give blood.2021. [Monograph on the internet]. [cited 2025 August 16]. Available from:https:\/\/www.blood.co.uk\/news-and-campaigns\/news-and-statements\/fair-steering-group\/"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12888"},{"key":"e_1_2_8_20_1","unstructured":"Canadian Blood Services.Sexual behaviour\u2010based screening.2022. [Monograph on the internet]. Available from:https:\/\/www.blood.ca\/en\/blood\/am\u2010i\u2010eligible\u2010donate\u2010blood\/sexual\u2010behaviour\u2010based\u2010screening"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/hematology.2023000482"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.18168"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17941"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.70085","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/trf.70085","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.70085","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T14:11:44Z","timestamp":1779113504000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.70085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,18]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/trf.70085"],"URL":"https:\/\/doi.org\/10.1111\/trf.70085","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,18]]},"assertion":[{"value":"2025-08-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}