{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T06:07:00Z","timestamp":1779170820327,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/T023961\/1"],"award-info":[{"award-number":["MR\/T023961\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Trauma\u2010induced coagulopathy (TIC) describes a complex set of coagulation changes affecting severely injured patients. The thrombomodulin\u2010protein C axis is central to the evolution of TIC. Soluble thrombomodulin (sTM) levels are elevated after injury and predict poor clinical outcomes. Recently, a heritable bleeding disorder defined by injury\u2010related excessive bleeding, markedly elevated sTM and a\n                      <jats:italic>THBD<\/jats:italic>\n                      mutation has been described. The clinical phenotype broadly mirrors that of trauma hemorrhage, and we hypothesized that their endothelial colony forming cells (ECFCs) could be used to model trauma\u2010induced endothelial damage.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design and Methods<\/jats:title>\n                    <jats:p>\n                      Our objectives were to: (a) define the hemostatic capacity of wild type (WT\u2010) and\n                      <jats:italic>THBD<\/jats:italic>\n                      variant (MT\u2010) ECFCs, using global hemostatic assays, (b) determine the hemostatic changes on ECFC surfaces after exposing cells to trauma stimuli, (c) evaluate the contributions of traumatized ECFCs and trauma patient plasma to overall hemostatic capacity, to better understand the injured endothelial\u2010coagulation interface.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We show that trauma stimuli cause significant, rapid shedding of TM from WT\u2010cells and this reduced membrane\u2010TM supports quicker fibrinolysis and greater thrombin generating capacity. Combining trauma plasma with traumatized ECFCs attenuates and\/or negates these effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This ECFC model provides novel mechanistic insights into TIC at the endothelial surface, informing future treatment strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.70089","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T09:25:51Z","timestamp":1769678751000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Endothelial thrombomodulin\u2014Its role in trauma\u2010induced coagulopathy"],"prefix":"10.1111","volume":"66","author":[{"given":"Jeries","family":"Abu\u2010Hanna","sequence":"first","affiliation":[{"name":"Oxford Haemophilia &amp; Thrombosis Centre Oxford University Hospitals NHS Foundation Trust  Oxford 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