{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T06:07:11Z","timestamp":1779170831664,"version":"3.51.4"},"reference-count":47,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100012399","name":"Biomedical Advanced Research and Development Authority","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hemorrhage is the leading cause of preventable death on and off the battlefield that leads to coagulation dysfunction and endotheliopathy. To improve understanding of the nature and timing of these pathologies, we sought to profile markers of coagulopathy and endotheliopathy between survivors and non\u2010survivors in a swine model of uncontrolled hemorrhage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design and Methods<\/jats:title>\n                    <jats:p>\n                      Anesthetized Yorkshire cross\u2010bred swine (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200939) were subjected to a 45\u2009s uncontrolled bleed following a 6\u2010mm laceration to the femoral artery. Following applications of various hemostatic dressings, anesthetized swine were monitored up to 24\u2009h with periodic blood sampling. Serum\/plasma was assayed for coagulopathy and endotheliopathy biomarkers and compared between survivors (24\u2009h post\u2010hemorrhage) and non\u2010survivors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The injury resulted in a 62% mortality with 95% succumbing to injury within ~3\u2009h. Hyaluronan and heparan sulfate were elevated in the fatality groups at 1\u2009h (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05) and 2\u2009h (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05), respectively. The fatality group at 1\u2009h exhibited reduced plasminogen activator inhibitor\u20101 (PAI\u20101,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001) and elevated tissue plasminogen activator (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.01) and D\u2010Dimer (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05) relative to survivors. Survivors experienced significant elevations in C\u2010reactive protein (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.0001), PAI\u20101 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.0001), heparan sulfate (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.0001), E\u2010selectin (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.0001), and vascular cell adhesion molecule\u20101 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.01) compared to baseline.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>These results suggest that acute fatalities undergo hyperfibrinolysis followed by glycocalyx shedding. Survivors may experience longer term complications due to delayed\/on\u2010going inflammation and\/or endothelium activation. This characterization of severe hemorrhage provides insights into the nature and progression of coagulopathy and endotheliopathy that emulate clinical findings which can be used for evaluating future therapeutics to reduce preventable deaths.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.70122","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T09:03:36Z","timestamp":1771232616000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of endotheliopathy and coagulopathy biomarkers with survival in a swine model of isolated uncontrolled hemorrhage"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9266-0123","authenticated-orcid":false,"suffix":"Jr.","given":"Alan","family":"Weaver","sequence":"first","affiliation":[{"name":"US Army Institute of Surgical Research  San Antonio Texas 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Antonio Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheresa","family":"Calhoun","sequence":"additional","affiliation":[{"name":"US Army Institute of Surgical Research  San Antonio Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Edwards","sequence":"additional","affiliation":[{"name":"US Army Institute of Surgical Research  San Antonio Texas USA"},{"name":"College of Veterinary Medicine Texas A&amp;M University  Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e3182755dcc"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-20-5452"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc10096"},{"key":"e_1_2_11_5_1","volume-title":"Near\u2010peer threats at highest point since cold war, DOD official 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