{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T17:29:29Z","timestamp":1788024569364,"version":"build-2784847793"},"reference-count":19,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100016318","name":"Cerus Corporation","doi-asserted-by":"publisher","award":["AGT011786"],"award-info":[{"award-number":["AGT011786"]}],"id":[{"id":"10.13039\/100016318","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In cases of massive transfusion, intravenous access can be limited. Additionally, delivering different products through separate lines and infusion methods adds unnecessary steps. RBC, plasma, and whole blood (WB) are delivered via rapid infusers; cryoprecipitate (CRYO) is infused through separate access and is not approved with these devices.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design and Methods<\/jats:title>\n                    <jats:p>We examined the impact of different transfusion methods on hemostatic performance and factor activity using two available CRYO products. Ten bags of CRYO, ten bags pathogen\u2010reduced CRYO (Intercept\u00ae Fibrinogen Complex, IFC), and 20\u2009units of WB were obtained. Each CRYO bag was infused with one unit of WB by three techniques: (1) gravity infusion with filter, (2) rapid infuser at 70\u2009mL\/min, and (3) pressure bag and filter. Hemostatic potential was measured by thrombelastography (TEG), thrombin generation (CAT), and factor levels (ACLTOP). Post\u2010each infusion, disposable tubing and infusion parts were inspected for evidence of clumping or clogging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both standard CRYO and IFC demonstrated maintained or improved TEG, CAT, and factor levels when subjected to a rapid infuser device and pressure bag. When compared with gravity infusion, a rapid infuser device and pressure bag demonstrated maintained or improved values by TEG, CAT, and factor activity. No evidence of clumping or clogging of tubing was encountered in the 20 runs performed. No evidence of system dysfunction with use of CRYO through these devices was found either.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Restriction of CRYO infusion through rapid infuser devices or with pressure bags should be reconsidered. Future clinical trials are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.70132","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T04:17:26Z","timestamp":1771474646000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The impact of rapid infusers on the hemostatic potential of cryoprecipitate products"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5030-8446","authenticated-orcid":false,"given":"Connor D.","family":"Purvis","sequence":"first","affiliation":[{"name":"Department of Surgery The McGovern Medical School at The University of Texas Health Science Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Redden","sequence":"additional","affiliation":[{"name":"Department of Surgery The McGovern Medical School at The University of Texas Health Science Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Jacobson","sequence":"additional","affiliation":[{"name":"Department of Surgery The McGovern Medical School at The University of Texas Health Science Center  Houston Texas USA"},{"name":"Joint Trauma System, Defense Health Agency, Joint Base San Antonio\u2010Fort Sam Houston  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao\u2010Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Surgery The McGovern Medical School at The University of Texas Health Science Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Surgery The McGovern Medical School at The University of Texas Health Science Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Cardenas","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Colorado\u2010Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4655-2527","authenticated-orcid":false,"given":"Jan\u2010Michael","family":"Van Gent","sequence":"additional","affiliation":[{"name":"Department of Surgery The McGovern Medical School at The University of Texas Health Science Center  Houston Texas USA"},{"name":"Joint Trauma System, Defense Health Agency, Joint Base San Antonio\u2010Fort Sam Houston  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4184-6742","authenticated-orcid":false,"given":"Bryan A.","family":"Cotton","sequence":"additional","affiliation":[{"name":"Department of Surgery The McGovern Medical School at The University of Texas Health Science Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,18]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"CryerHG NathensAB BulgerEM CallandJF CohenMJ CottonBA.ACS TQIP Massive Transfusion in Trauma Guidelines.2014Accessed November 18 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with rapid transfusion systems in the trauma setting","volume":"47","author":"Kim P","year":"2004","journal-title":"Can J Surg"},{"key":"e_1_2_9_15_1","first-page":"487","article-title":"Routine extracorporeal circulation with a centrifugal or roller pump","volume":"37","author":"Jakob HG","year":"1991","journal-title":"ASAIO Trans"},{"key":"e_1_2_9_16_1","first-page":"319","article-title":"Mechanism action of platelets and crucial blood coagulation pathways in hemostasis","volume":"11","author":"Periayah MH","year":"2017","journal-title":"Int J Hematol Oncol Stem Cell Res"},{"key":"e_1_2_9_17_1","first-page":"328","article-title":"Trauma induced coagulopathy and fibrinogen levels: why do we need to measure them, and what are the supplementation strategies?","volume":"35","author":"Savioli F","year":"2023","journal-title":"Crit Care 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