{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:55:43Z","timestamp":1790675743717,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Transfusion medicine represents the earliest and most enduring example of biotherapy, originating with Blundell's first successful human blood transfusion in 1818 and transformed into a precise, reliable treatment through Landsteiner's discovery of the ABO blood group system in 1901. These foundational advances established the therapeutic use of living cells and created the systems of donor stewardship, product safety, and laboratory precision that continue to define the field today. This commentary outlines how transfusion medicine built the operational, scientific, and regulatory frameworks that underpin the modern era of cellular and gene therapies (CGTs). The principles essential to transfusion, that is, safe donor management, standardized collection and processing, compatibility and infectious agents testing, GMP\/GTP manufacturing, and robust quality systems, form the backbone of hematopoietic cell transplantation, engineered immunotherapies such as CAR\u2010T cells, and emerging regenerative and gene\u2010editing technologies. We herein highlight the central role of transfusion professionals in apheresis, cell processing, logistics, and quality assurance. A global perspective underscores that access to high\u2010quality transfusion services is a prerequisite for equitable access to CGTs and that sustainable investment in transfusion infrastructure remains essential, particularly in low\u2010 and middle\u2010income countries. Transfusion medicine is not a historical precursor to cellular therapy; it is an active leader in shaping the future of biotherapies. Its century\u2010long commitment to safety, quality, and innovation provides the foundation on which advanced cellular and gene\u2010based therapies continue to evolve. By carrying forward these principles, transfusion medicine ensures that the promise of regenerative medicine and immunotherapy is realized safely, effectively, and equitably worldwide.<\/jats:p>","DOI":"10.1111\/trf.70162","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T08:26:02Z","timestamp":1790411162000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["From blood to biotherapies: A brief historical perspective"],"prefix":"10.1111","volume":"66","author":[{"given":"Jose A.","family":"Cancelas","sequence":"first","affiliation":[{"name":"Dana Farber Cancer Institute Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1089-5787","authenticated-orcid":false,"given":"Meghan","family":"Delaney","sequence":"additional","affiliation":[{"name":"Division of Pathology and Laboratory Medicine Children's National Hospital  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1530-7980","authenticated-orcid":false,"given":"Richard","family":"Sch\u00e4fer","sequence":"additional","affiliation":[{"name":"Institute of Transfusion Medicine and Gene Therapy Medical Center \u2013 University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/09595287180090P107"},{"key":"e_1_2_11_3_1","first-page":"357","article-title":"Zur Kenntnis der antifermentativen, lytischen und agglutinierenden Wirkungen des Blutserums und der Lymphe","volume":"27","author":"Landsteiner K","year":"1901","journal-title":"Zentralbl Bakteriol"},{"key":"e_1_2_11_4_1","volume-title":"Standards for blood banks and transfusion services","author":"AABB","year":"2026"},{"issue":"4","key":"e_1_2_11_5_1","first-page":"95","article-title":"Bone marrow transplantation: a review","volume":"36","author":"Thomas ED","year":"1999","journal-title":"Semin Hematol"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V75.3.555.555"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.2920100308"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aar6711"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2025.09.013"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5346.2130"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.11.019"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.02.008"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1800729"},{"key":"e_1_2_11_14_1","volume-title":"Standards for cellular therapy services","author":"AABB","year":"2025"},{"key":"e_1_2_11_15_1","volume-title":"International standards for hematopoietic cellular therapy product collection, processing, and administration","author":"FACT\u2013JACIE Standards Committee","year":"2026"},{"key":"e_1_2_11_16_1","unstructured":"AABB National Blood Exchange Program.Program overview.https:\/\/www.aabb.org\/corporate-solutions\/aabb-services\/national-blood-exchange"},{"key":"e_1_2_11_17_1","unstructured":"Approved Cellular and Gene Therapy Products | FDA.https:\/\/www.fda.gov\/vaccines\u2010blood\u2010biologics\/cellular\u2010gene\u2010therapy\u2010products\/approved\u2010cellular\u2010and\u2010gene\u2010therapy\u2010products"},{"key":"e_1_2_11_18_1","unstructured":"European Medicines Agency.ATMP Approvals 2009\u20132025.https:\/\/pharmaboardroom.com\/facts\/european-medicines-agency-atmp-approvals-2009-2025"},{"key":"e_1_2_11_19_1","unstructured":"Science Techniz.https:\/\/www.sciencetechniz.com\/2024\/01\/the-gene-therapy-is-here-but-many-will."},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2024.11.015"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2025.05.014"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021012248"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.70162","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/trf.70162","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.70162","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:00:31Z","timestamp":1790672431000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.70162"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":21,"journal-issue":{"issue":"S2","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/trf.70162"],"URL":"https:\/\/doi.org\/10.1111\/trf.70162","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2025-12-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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