{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T15:05:35Z","timestamp":1789657535606,"version":"4.0.1"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Forschung, Technologie und Raumfahrt","doi-asserted-by":"publisher","award":["01KD25030"],"award-info":[{"award-number":["01KD25030"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>High\u2010dose chemotherapy followed by autologous stem cell transplantation (ASCT) remains the standard of care for fit patients with newly diagnosed multiple myeloma (MM). The increasing use of CD38 antibody\u2010based quadruplet induction regimens such as daratumumab\u2010VTd (Dara\u2010VTd) has raised concerns regarding impaired stem cell mobilization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design and Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a retrospective single\u2010center analysis comparing steady\u2010state stem cell mobilization after Dara\u2010VTd versus bortezomib\u2013cyclophosphamide\u2013dexamethasone (VCd) induction. Mobilization kinetics, plerixafor use, and CD34\n                      <jats:sup>+<\/jats:sup>\n                      collection outcomes were evaluated. CD34\n                      <jats:sup>+<\/jats:sup>\n                      counts prior to first apheresis were adjusted for plerixafor use (adjCD34\n                      <jats:sup>+<\/jats:sup>\n                      ). Multivariate logistic regression was performed to identify predictors of mobilization success.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 153 patients, 85 received Dara\u2010VTd and 68 received VCd. Despite significantly deeper responses after Dara\u2010VTd (\u2265VGPR 81% vs. 42%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.01), these patients showed lower adjCD34\n                      <jats:sup>+<\/jats:sup>\n                      counts prior to first apheresis (16 vs. 50\/\u03bcL;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.01) and required plerixafor more frequently (64% vs. 15%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.01). Nevertheless, cumulative CD34\n                      <jats:sup>+<\/jats:sup>\n                      yields were comparable between Dara\u2010VTd and VCd (6.4 vs. 6.0\u2009\u00d7\u200910\n                      <jats:sup>6<\/jats:sup>\n                      CD34\n                      <jats:sup>+<\/jats:sup>\n                      cells\/kg;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.15), and target yields were achieved in the majority of patients proceeding to apheresis (90% vs. 94%). Dara\u2010VTd induction, prior radiation, and high tumor burden were identified as independent negative predictors of mobilization success.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Although Dara\u2010VTd induction is associated with impaired mobilization kinetics, successful steady\u2010state mobilization remains feasible. On\u2010demand plerixafor use overcomes mobilization deficits, supporting this approach in patients receiving CD38\u2010based quadruplet induction therapy. Furthermore, follow\u2010up analysis of stem cell graft utilization demonstrates a high proportion of collected but unused stem cell grafts in both cohorts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.70165","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T11:01:37Z","timestamp":1774004497000},"page":"751-762","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Steady\u2010state mobilization with on\u2010demand plerixafor after\n                    <scp>CD38<\/scp>\n                    antibody\u2010based induction in multiple myeloma patients"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8213-2047","authenticated-orcid":false,"given":"Maximilian Alexander","family":"R\u00f6hnert","sequence":"first","affiliation":[{"name":"Department of Medicine I, Faculty of Medicine and University Hospital Carl Gustav Carus TUD Dresden University of Technology  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Seifert","sequence":"additional","affiliation":[{"name":"Department of Medicine I, Faculty of Medicine and University Hospital Carl Gustav Carus TUD Dresden University of Technology  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9050-1049","authenticated-orcid":false,"given":"Karolin","family":"Trautmann\u2010Grill","sequence":"additional","affiliation":[{"name":"Department of Medicine I, Faculty of Medicine and University Hospital Carl Gustav Carus TUD Dresden University of Technology  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3791-0548","authenticated-orcid":false,"given":"Christoph","family":"R\u00f6llig","sequence":"additional","affiliation":[{"name":"Department of Medicine I, Faculty of Medicine and University Hospital Carl Gustav Carus TUD Dresden University of Technology  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Zimmer","sequence":"additional","affiliation":[{"name":"Department of Medicine I, Faculty of Medicine and University Hospital Carl Gustav Carus TUD Dresden University of Technology  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0472-4335","authenticated-orcid":false,"given":"Katharina","family":"Egger\u2010Heidrich","sequence":"additional","affiliation":[{"name":"Department of Medicine I, Faculty of Medicine and University Hospital Carl Gustav Carus TUD Dresden University of Technology  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Bill","sequence":"additional","affiliation":[{"name":"Department of Medicine I, Faculty of Medicine and University Hospital Carl Gustav Carus TUD Dresden University of Technology  Dresden 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