{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T06:07:06Z","timestamp":1779170826602,"version":"3.51.4"},"reference-count":44,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Low Titer Group O Whole Blood (LTOWB) use has expanded to include patients with non\u2010traumatic bleeding etiologies. While a large body of evidence supports a potential survival benefit of LTOWB in trauma patients, data demonstrating the safety and efficacy of LTOWB in non\u2010trauma patients are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design and Methods<\/jats:title>\n                    <jats:p>Non\u2010trauma adult patients at two hospitals who received at least one unit of LTOWB were included in the study. Patient demographics, transfusion and laboratory data, diagnoses, mortality, and hospital length of stay were collected between January 1, 2018, and June 30, 2024. LTOWB recipients were further stratified by O versus non\u2010group O blood group, and laboratory markers of renal failure and hemolysis were compared between these two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 319 unique patients with 320 LTOWB transfusion episodes were included. The most common indications for transfusion were gastrointestinal and cardiovascular bleeding (266\/320, 83%). In\u2010hospital survival at 24 h and 30\u2009days posttransfusion was 75% and 53%, respectively. There was no statistically significant difference in markers of hemolysis between group O and non\u2010group O LTOWB recipients. There were no reported transfusion reactions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>In non\u2010trauma settings, LTOWB was most commonly utilized in patients with gastrointestinal and cardiovascular bleeding. LTOWB is a safe alternative to component therapy in non\u2010trauma adult populations. However, additional studies are needed to focus on efficacy and clinical outcomes in non\u2010trauma patients that receive LTOWB for severe hemorrhage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.70172","type":"journal-article","created":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T06:56:31Z","timestamp":1775890591000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Utilization and safety outcomes following the use of low titer group O whole blood in non\u2010trauma patients"],"prefix":"10.1111","volume":"66","author":[{"given":"Jozsef","family":"Bordas","sequence":"first","affiliation":[{"name":"Department of Pathology University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"},{"name":"Management Services Our Blood Institute  Oklahoma City Oklahoma 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