{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T06:04:23Z","timestamp":1781071463325,"version":"3.54.1"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2026,6]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Umbilical cord blood (UCB) is a rich source of hematopoietic stem and progenitor cells for regenerative medicine. This study characterized the cellular composition of UCB from twin pregnancies to identify blood type concordance (BTC)\u2010related differences.<\/jats:p>\n <\/jats:sec>\n \n Study Design and Methods<\/jats:title>\n A cross\u2010sectional study was conducted at the Vinmec Tissue Biobank, involving 128 twin deliveries (2019\u20132023). Linear correlation and mixed\u2010effect modeling were employed to analyze relationships between cellular factors and BTC in twins.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Maternal and gestational ages were 31.9\u2009\u00b1\u20095.56\u2009years and 36.7\u2009\u00b1\u20091.42\u2009weeks. Neonatal weight averaged 2470.68\u2009\u00b1\u2009382.5\u2009g, with ABO blood type discordance (ABO\u2010BTD) twins significantly heavier than ABO\u2010BTC twins (\n p<\/jats:italic>\n \u2009<\u20090.05). UCB volume exceeded 100\u2009mL, positively correlating with birth weight and cellular yields. BTC twins exhibited higher pre\u2010processing mononuclear cell (MNC) and lymphocyte\u2010monocyte (L\u2010M) counts and post\u2010processing white blood cell (WBC) and MNC counts. Recovery rates for total nucleated cells (TNCs) and MNCs were 86.14\u2009\u00b1\u200915.72% and 96.47\u2009\u00b1\u200917.77%. CD34+ cell counts were higher in the BTD twins (\n p<\/jats:italic>\n \u2009<\u20090.05), while hematocrit was lower (p\u2009<\u20090.05). Strong positive correlations were found between UCB volume and TNC, MNC, and CD34+ counts, whereas hematocrit showed weak or negative associations. Mixed\u2010effect modeling confirmed higher TNC and WBC counts in BTD twins before and after processing (\n p<\/jats:italic>\n \u2009<\u20090.05), independent of intra\u2010pair variability.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n ABO\u2010BTC significantly influences UCB cellular yield, with ABO\u2010BTD twins offering superior hematopoietic stem cell recovery potential for cord blood banking and clinical use.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/trf.70199","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T05:47:33Z","timestamp":1775627253000},"page":"1141-1150","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["ABO blood type concordance\u2010dependent variations in umbilical cord blood: Insights from twin pregnancies"],"prefix":"10.1111","volume":"66","author":[{"given":"Van\u2010Tinh","family":"Nguyen","sequence":"first","affiliation":[{"name":"Vinmec Hi\u2010Tech Center Vinmec Healthcare System Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi\u2010Thao","family":"Chu","sequence":"additional","affiliation":[{"name":"Vinmec Hi\u2010Tech Center Vinmec Healthcare System Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kien\u2010Thach","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Vinmec Hi\u2010Tech Center Vinmec Healthcare System Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong\u2010Luc","family":"Le","sequence":"additional","affiliation":[{"name":"Vinmec Hi\u2010Tech Center Vinmec Healthcare System Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duc\u2010Hung","family":"Hoang","sequence":"additional","affiliation":[{"name":"Vinmec Hi\u2010Tech Center Vinmec Healthcare System Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi Thanh\u2010Ha","family":"Luong","sequence":"additional","affiliation":[{"name":"Vinmec Hi\u2010Tech Center Vinmec Healthcare System Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"The\u2010Dung","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Vinmec Hi\u2010Tech Center Vinmec Healthcare System Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan\u2010Hung","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Vinmec Hi\u2010Tech Center Vinmec Healthcare System Hanoi Vietnam"},{"name":"Vinmec\u2010VinUni Institute of Immunology College of Health Sciences, VinUniversity Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2847-7068","authenticated-orcid":false,"given":"Uyen Thi Trang","family":"Than","sequence":"additional","affiliation":[{"name":"Vinmec\u2010VinUni Institute of Immunology College of Health Sciences, VinUniversity Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60915-5"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.18332\/ejm\/192930"},{"key":"e_1_2_11_4_1","doi-asserted-by":"crossref","unstructured":"AliH Al\u2010MullaF.Defining umbilical cord blood stem cells.2012.","DOI":"10.4236\/scd.2012.21003"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-016-0363-7"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-024-05758-0"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/stcltm\/szad071"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-02-453175"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.12571"},{"issue":"10","key":"e_1_2_11_10_1","article-title":"Delivery methods in twin gestations: evaluating outcomes, risk factors, and the paradigm shift towards elective cesarean deliveries","volume":"15","author":"Abraham M","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.21907"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-6-3"},{"key":"e_1_2_11_13_1","unstructured":"Maternal N. a. G. S. E. L. C.South Australian perinatal practice guideline. Multiple pregnancy: Department for Health and Wellbeing Government of South Australia.2023https:\/\/www.sahealth.sa.gov.au\/wps\/wcm\/connect\/4f4b69804eedff43b818bb6a7ac0d6e4\/Multiple+Pregnancy+PPG_+v6_0.pdf?MOD=AJPERES&CACHEID=ROOTWORKSPACE\u20104f4b69804eedff43b818bb6a7ac0d6e4\u2010p4cjTar"},{"key":"e_1_2_11_14_1","volume-title":"Multiple pregnancy: new challenges","author":"Santana EFM","year":"2018"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2018.02.004"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e318195bd57"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2014.09.003"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12481"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12340"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200006223422501"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.4103\/ajts.AJTS_124_18"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.70199","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/trf.70199","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.70199","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T05:29:57Z","timestamp":1781069397000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.70199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,7]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/trf.70199"],"URL":"https:\/\/doi.org\/10.1111\/trf.70199","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,7]]},"assertion":[{"value":"2025-10-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}