{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:22:10Z","timestamp":1787016130420,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000014","name":"Canadian Blood Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000014","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Red blood cell (RBC) transfusions are part of essential supportive therapy in patients with acute leukemia, where patients often present with anemia and thrombocytopenia. Together these cytopenias increase bleeding risk; however, optimal hemoglobin (Hb) thresholds for RBC transfusion remain undefined, and current recommendations for restrictive strategies (&lt;7\u2009g\/dL) are based on low\u2010certainty, indirect evidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design and Methods<\/jats:title>\n                    <jats:p>A national web\u2010based survey was distributed to 43 physicians (24 centers, Canada) to assess current RBC transfusion practice in patients with acute leukemia, perceptions of a liberal threshold (11\u2009g\/dL) in the context of a clinical trial, and feasibility considerations. The survey included categorical responses and open\u2010text fields.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 38 eligible physicians, 34 responded (89%). For stable, non\u2010bleeding patients receiving induction chemotherapy, 27\/34 (79%) used a Hb threshold of 7\u2009g\/dL, 6\/34 (18%) used 8\u2009g\/dL, and 1\/34 (3%) used 9\u2009g\/dL. Fourteen (14\/34, 41%) respondents indicated that a Hb threshold of 11\u2009g\/dL was reasonable for the liberal arm of a clinical trial, while 20\/34 (59%) did not. For such a trial, 32\/34 (94%) would consider enrolling patients in the trial and 2\/34 (6%) would not.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>A Hb threshold of 7\u2009g\/dL was most reported as standard\u2010of\u2010care. Most respondents supported enrolling their patients in a clinical trial comparing a liberal RBC transfusion strategy of 11\u2009g\/dL with standard\u2010of\u2010care. The feasibility of 11\u2009g\/dL should be tested with clear justification, appropriate study outcomes, and attention to safety risks and resource demands.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.70202","type":"journal-article","created":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T06:01:38Z","timestamp":1777096898000},"page":"1079-1084","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Red blood cell transfusion thresholds in acute leukemia: Current practice and physician perspectives from a national survey"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5879-4179","authenticated-orcid":false,"given":"Dimpy","family":"Modi","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences, Medical Sciences Graduate Program McMaster University  Hamilton Ontario Canada"},{"name":"Michael G. DeGroote Centre for Transfusion Research McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8776-4083","authenticated-orcid":false,"given":"Brett L.","family":"Houston","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Max Rady College of Medicine University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Leber","sequence":"additional","affiliation":[{"name":"Department of Medicine McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Jamula","sequence":"additional","affiliation":[{"name":"Michael G. DeGroote Centre for Transfusion Research McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Heddle","sequence":"additional","affiliation":[{"name":"Michael G. DeGroote Centre for Transfusion Research McMaster University  Hamilton Ontario Canada"},{"name":"Department of Medicine McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Hillis","sequence":"additional","affiliation":[{"name":"Department of Oncology McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6489-6980","authenticated-orcid":false,"given":"Michelle P.","family":"Zeller","sequence":"additional","affiliation":[{"name":"Michael G. DeGroote Centre for Transfusion Research McMaster University  Hamilton Ontario Canada"},{"name":"Department of Medicine McMaster University  Hamilton Ontario Canada"},{"name":"Medical Services Canadian Blood Services  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Berg","sequence":"additional","affiliation":[{"name":"Department of Oncology McMaster University  Hamilton Ontario Canada"},{"name":"Centre for Discovery in Cancer Research McMaster University and Hamilton Health Sciences  Hamilton Ontario Canada"},{"name":"Escarpment Cancer Research Institute McMaster University and Hamilton Health Sciences  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald M.","family":"Arnold","sequence":"additional","affiliation":[{"name":"Michael G. DeGroote Centre for Transfusion Research McMaster University  Hamilton Ontario Canada"},{"name":"Department of Medicine McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2021.06.001"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.12914"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1711818"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1012452"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199902113400601"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020001920"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx758"},{"issue":"11","key":"e_1_2_8_9_1","first-page":"1530","article-title":"The risk of bleeding in thrombocytopenic patients with acute myeloid leukemia","volume":"91","author":"Webert K","year":"2006","journal-title":"Haematologica"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-01-757930"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.12-6-727"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103208"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781394260645"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-021-06737-1"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2021.279867"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01485.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13658"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.2450\/BloodTransfus.482"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V126.23.1138.1138"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.70202","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/trf.70202","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.70202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T05:30:17Z","timestamp":1781069417000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.70202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,24]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/trf.70202"],"URL":"https:\/\/doi.org\/10.1111\/trf.70202","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,24]]},"assertion":[{"value":"2025-10-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}