{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T06:04:08Z","timestamp":1781071448789,"version":"3.54.1"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Anti\u2010M antibodies were described as rarely eliciting hemolytic disease of the fetus and newborn (HDFN) in pregnancy. More recent literature, primarily from Asia, reports severe HDFN attributed to maternal anti\u2010M. The objective of this study is to determine if there is a difference in the frequency and\/or severity of anti\u2010M HDFN among subjects who self\u2010report as Asian compared to non\u2010Asian.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective data were collected from 18 sites. Fetuses\/neonates affected by HDFN were categorized as unaffected, mild, moderate, or severe based on clinical management and outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Anti\u2010M was identified in 557 obstetric patients. Among 332 neonates with complete data for analysis, anti\u2010M was detected in isolation during the pregnancies of 210 (63.3%) neonates; 198 (94.3%) were unaffected by HDFN. The overall frequency of HDFN was 6.5% (2\/31) in Asian patients and 5.6% (10\/179) in non\u2010Asian patients. The frequency of severe HDFN was 6.5% (2\/31) among Asian patients and 0.6% (1\/179) among non\u2010Asian patients. Among non\u2010Asian patients, eight (4.5%) were mild and one (0.6%) was moderate. Of 63 pregnancies with anti\u2010M and ABO incompatibility, 6 (9.5%) were associated with mild HDFN and 57 (90.5%) were unaffected. Of 49 pregnancies with anti\u2010M and non\u2010ABO antibody(s), 6 (12.2%) were associated with mild HDFN and 43 (87.8%) were unaffected. One case (10.0%) of HDFN (mild) occurred in the presence of anti\u2010M, additional antibody(s), and ABO incompatibility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this study, severe anti\u2010M HDFN was rare in non\u2010Asian subjects. There is a signal that Asian patients are at greater risk for severe anti\u2010M HDFN.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.70210","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T08:34:25Z","timestamp":1775464465000},"page":"1086-1098","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical significance of anti\u2010M in pregnancy and self\u2010reported ancestry: The\n                    <scp>BEST<\/scp>\n                    collaborative study"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2292-3167","authenticated-orcid":false,"given":"Wen","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa","family":"Ziman","sequence":"additional","affiliation":[{"name":"Wing\u2010Kwai and Alice Lee\u2010Tsing Chung Transfusion Service, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine University of California Los Angeles  California Los Angeles USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0322-5240","authenticated-orcid":false,"given":"Charles","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6404-1931","authenticated-orcid":false,"given":"Matthew T. 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