{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T03:30:42Z","timestamp":1787628642307,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Alpha\u2010gal syndrome (AGS), a distinct form of IgE\u2010mediated hypersensitivity to the carbohydrate galactose\u2010\u03b1\u20101,3\u2010galactose (\u03b1\u2010Gal), typically occurs after repeated tick bites and leads to allergic reactions after ingestion of mammalian meat. Patients with AGS may experience a broad spectrum of allergic reactions, from pruritus and urticaria to angioedema and anaphylaxis. Although classically associated with food\u2010triggered reactions, emerging reports describe AGS\u2010related anaphylaxis following exposure to group B blood products, including cases without accompanying gastrointestinal symptoms, highlighting an underrecognized clinical presentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Report<\/jats:title>\n                    <jats:p>A 29\u2010year\u2010old group O male with chronic myelogenous leukemia, status post stem cell transplant from group A donor, with extensive pancytopenia, received multiple blood products, including red blood cells and platelets. Although most of the transfusions were uneventful, he developed allergic reactions repeatedly, from mild to anaphylactic reactions during the transfusion of group AB or B platelets. A history of tick bites was confirmed without establishing an association between his symptoms and meat consumption. A mildly elevated galactose\u2010\u03b1\u20101,3\u2010galactose IgE was detected. No additional allergic reactions were observed after strict use of non\u2010B blood products was implemented.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This case demonstrates a possible clinical association between AGS and anaphylactic transfusion reaction to group B blood products in non\u2010B recipients. Early laboratory workups for AGS antibodies are recommended in non\u2010B patients with a history of tick exposure and severe allergic reactions to meat consumption or transfusion of group B blood products. Meanwhile, transfusion of group B blood products should be avoided once AGS is suspected clinically in non\u2010B patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.70212","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T06:08:21Z","timestamp":1775542101000},"page":"1690-1693","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Anaphylactic transfusion reaction to group B platelets related to alpha\u2010gal syndrome: A case report"],"prefix":"10.1111","volume":"66","author":[{"given":"Oscar Andre","family":"Hinojosa","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Kansas Medical Center  Kansas City Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amitava","family":"Dasgupta","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Kansas Medical Center  Kansas City Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2378-3813","authenticated-orcid":false,"given":"Zhan","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Kansas Medical Center  Kansas City Missouri USA"},{"name":"Community Blood Center of Kansas City  Kansas City Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.12.591"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.01.047"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/falgy.2021.783279"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2019.09.017"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17521"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17811"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwf087"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199708150-00032"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2019.03.031"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17319"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.26857"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.02.016"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2022.08.028"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.70030"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.18338"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.70212","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/trf.70212","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.70212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T18:28:57Z","timestamp":1786213737000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.70212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,6]]},"references-count":15,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/trf.70212"],"URL":"https:\/\/doi.org\/10.1111\/trf.70212","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,6]]},"assertion":[{"value":"2026-02-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}