{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T15:52:24Z","timestamp":1782921144722,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006083","name":"Ministry of Defence","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006083","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Dried plasma is an attractive option when provision of frozen plasma is challenging. FrontlineODP\u2122 system (Velico Medical) is a spray drying system producing a unit of spray dried plasma (SDP), in a blood bag, in around 30\u2009min. This study evaluates coagulation parameters before and after drying, using two types of starting plasma: Whole blood (WB) derived, and apheresis derived.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A minimum of 15 units each of WB derived CPD\u2010anticoagulated plasma and plasmapheresis (Aurora, Fresenius Kabi) sodium citrate\u2010anticoagulated plasma were sampled and frozen within 12\u201318\u2009h of venepuncture. Units were spray dried using the Velico FrontlineODP\u2122 system. Following rehydration with sterile water, further samples were taken. All samples (pre drying, immediately post rehydration and 6\u2009h post rehydration) were tested in parallel for a range of coagulation parameters, including thrombin generation, as well as biochemical parameters and bacterial contamination.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n All dried plasma units rehydrated in an average of 6\u2009min. All coagulation parameters were within \u00b120% pre to post drying, except von Willebrand factor (vWF) activity and FXIII activity, which decreased by approximately 50% and 25%, respectively. Further investigation of vWF showed a change in the ratio of high and low molecular weight multimers. No bacterial contamination was detected in any of the units.<\/jats:p>\n <\/jats:sec>\n \n Summary\/Conclusions<\/jats:title>\n The FrontlineODP system can be incorporated into a standard blood service laboratory environment and successfully produce SDP with acceptable levels of coagulation proteins. Clinical data assessing SDP in a relevant patient population are now needed.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/trf.70219","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T15:29:21Z","timestamp":1782919761000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Spray dried plasma manufactured from apheresis and whole blood derived plasma"],"prefix":"10.1111","author":[{"given":"Lucy","family":"Bower","sequence":"first","affiliation":[{"name":"Component Development Laboratory NHS Blood and Transplant Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5611-554X","authenticated-orcid":false,"given":"Sian","family":"Huish","sequence":"additional","affiliation":[{"name":"Component Development Laboratory NHS Blood and Transplant Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Oleniacz","sequence":"additional","affiliation":[{"name":"Component Development Laboratory NHS Blood and Transplant Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Ellington","sequence":"additional","affiliation":[{"name":"Department of Haematology University of Cambridge Cambridge UK"},{"name":"Academic Department of Military Emergency Medicine Royal Centre for Defence Medicine Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2131-2281","authenticated-orcid":false,"given":"Melanie J.","family":"Robbins","sequence":"additional","affiliation":[{"name":"Component Development Laboratory NHS Blood and Transplant Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Woolley","sequence":"additional","affiliation":[{"name":"Academic Department of Military Anaesthesia and Critical Care Research & Clinical Innovation Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihae","family":"Sohn","sequence":"additional","affiliation":[{"name":"Velico Medical Beverly Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Green","sequence":"additional","affiliation":[{"name":"Centre for Trauma Sciences, Blizard Institute Queen Mary University of London London UK"},{"name":"NHS Blood and Transplant London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Cardigan","sequence":"additional","affiliation":[{"name":"Component Development Laboratory NHS Blood and Transplant Cambridge UK"},{"name":"Department of Haematology University of Cambridge Cambridge 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