{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T01:27:45Z","timestamp":1793582865580,"version":"4.5.0"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hepatitis E virus (HEV) infection is a common and usually asymptomatic infection but can be fatal in the context of prolonged immune suppression, such as during a hematopoietic stem cell transplant (HSCT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Report<\/jats:title>\n                    <jats:p>We describe the case of a 74\u2010year\u2010old man with primary central nervous system lymphoma (PCNSL) who required an autologous stem cell transplant (ASCT) as part of curative treatment for this condition but was identified to have acute HEV infection at the time of CD34 stem cell harvest. This meant he would be re\u2010exposed to a contaminated product with HEV infection at high viral load precisely at the time of most severe immune suppression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This is the first case of the prospective use of a CD34\u2010contaminated hepatitis E stem cell product with a high viral load (2,950,000\u2009IU\/mL) in an autologous stem cell transplant setting. We describe the successful prophylaxis with ribavirin. This case provides a practical management strategy for a HSCT, particularly in the allogeneic setting, where time\u2010critical donor CD34 products are required where acute HEV infection is detected. Our patient remains alive at &gt;12\u2009months post\u2010transplant with no evidence of HEV re\u2010activation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.70228","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T10:30:38Z","timestamp":1776335438000},"page":"1449-1453","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Successful re\u2010infusion of hepatitis E contaminated stem cells during autologous stem cell transplantation with ribavirin prophylaxis"],"prefix":"10.1111","volume":"66","author":[{"given":"Hannah","family":"Sadler","sequence":"first","affiliation":[{"name":"Great Western Hospital NHS Foundation Trust  Swindon UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Knightly","sequence":"additional","affiliation":[{"name":"Great Western Hospital NHS Foundation Trust  Swindon UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isobelle","family":"Waite","sequence":"additional","affiliation":[{"name":"Great Western Hospital NHS Foundation Trust  Swindon UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayley","family":"Aplin","sequence":"additional","affiliation":[{"name":"Great Western Hospital NHS Foundation Trust  Swindon UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander David","family":"Mangan","sequence":"additional","affiliation":[{"name":"Great Western Hospital NHS Foundation Trust  Swindon UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Austin","sequence":"additional","affiliation":[{"name":"Great Western Hospital NHS Foundation Trust  Swindon UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany","family":"Chan","sequence":"additional","affiliation":[{"name":"Great Western Hospital NHS Foundation Trust  Swindon UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rezarta","family":"Fekollari","sequence":"additional","affiliation":[{"name":"Great Western Hospital NHS Foundation Trust  Swindon UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0989-8091","authenticated-orcid":false,"given":"Ines","family":"Ushiro\u2010Lumb","sequence":"additional","affiliation":[{"name":"Organ and Tissue Donation and Transplantation NHS Blood and Transplant (NHSBT)  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Kent","sequence":"additional","affiliation":[{"name":"Great Western Hospital NHS Foundation Trust  Swindon UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moby","family":"Joseph","sequence":"additional","affiliation":[{"name":"Great Western Hospital NHS Foundation Trust  Swindon UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samreen","family":"Ijaz","sequence":"additional","affiliation":[{"name":"Blood Borne Virus Unit UKHSA, UK Health Security Agency  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Griffith","sequence":"additional","affiliation":[{"name":"Great Western Hospital NHS Foundation Trust  Swindon UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9045-5870","authenticated-orcid":false,"given":"Marcin","family":"Lubowiecki","sequence":"additional","affiliation":[{"name":"Great Western Hospital NHS Foundation Trust  Swindon UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61849-7"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.04078.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2019.08.002"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-03-492363"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-021-01497-2"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61034-5"},{"key":"e_1_2_10_8_1","unstructured":"Advisory committee on the Safety of Blood Tissues and Organs (SaBTO).Guidelines from the expert advisory committee on the Safety of Blood Tissues and Organs (SaBTO) on measures to protect patients from acquiring hepatitis E virus via transfusion or transplantation.2017[cited 2025 Aug 13]. Available from:https:\/\/assets.publishing.service.gov.uk\/media\/5a7c41ea40f0b62dffde0e0f\/Hepatitis_E_Guidelines.pdf"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2016.337"},{"issue":"1","key":"e_1_2_10_10_1","first-page":"680","article-title":"Hepatitis E virus (HEV) contaminated hematopoietic stem cell graft in a matched unrelated donor transplantation","volume":"55","author":"Boriskina K","year":"2020","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-011-0220-7"},{"key":"e_1_2_10_12_1","unstructured":"WMDA.Probable donor\u2013recipient transmission of hepatitis E virus through a cellular product. [cited 2026 Feb 18]. Available from:https:\/\/share.wmda.info\/spaces\/PromotingDonorCare\/pages\/444630413\/Rapid+Alerts+and+SPEAR+Communication"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01582-5"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2024.286132"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18135"},{"key":"e_1_2_10_16_1","unstructured":"Electronic Medicines Compendium.Ribavirin 200 mg film\u2010coated tablets. [cited 2025 Aug 13]. Available from:https:\/\/www.medicines.org.uk\/emc\/product\/7108\/smpc"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fm.2024.104529"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2005.01451.x"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.70228","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/trf.70228","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.70228","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T01:00:57Z","timestamp":1793581257000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.70228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,16]]},"references-count":17,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/trf.70228"],"URL":"https:\/\/doi.org\/10.1111\/trf.70228","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,16]]},"assertion":[{"value":"2026-01-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}