{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:19:25Z","timestamp":1792174765095,"version":"4.4.0"},"reference-count":49,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100017530","name":"Fresenius Kabi","doi-asserted-by":"publisher","award":["5800134\u2010FPG"],"award-info":[{"award-number":["5800134\u2010FPG"]}],"id":[{"id":"10.13039\/100017530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The BORN trial suggested that using cord blood\u2010red blood cells (CB\u2010RBCs) to transfuse severely preterm neonates significantly improves clinical outcomes compared to standard adult donor RBCs (A\u2010RBC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design and Methods<\/jats:title>\n                    <jats:p>The study illustrates CB\u2010RBC concentrate production and inventory management across nine CB banks participating in the BORN trial. Quality requirements were those established by the European regulation for leukocyte\u2010depleted RBC concentrates in additive solution. The compliance rate among centers was reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During the BORN study, 451 CB\u2010RBC units were processed and 107 were transfused to 69 patients in the intervention arm. However, for 67 transfusion requests, no compatible CB\u2010RBC units were available and adult\u2010RBCs were given. The CB\u2010RBC inventory comprised a minor fraction of CB units collected during the study period, suggesting that many did not meet the protocol\u2010defined volume threshold of 67\u2009mL at collection. Quality control results showed that 84.0% of units achieved target hematocrit (Htc) levels (50\u201370%), with higher success rates in centers processing more CB units. All centers met quality standards, maintaining residual leukocytes below 1\u2009\u00d7\u200910\n                      <jats:sup>6<\/jats:sup>\n                      and end\u2010storage hemolysis below 0.8% in more than 90% of cases. CB\u2010RBC availability was significantly limited by the time required for bacterial testing results and the need for \u03b3\u2010irradiation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>These data suggest that the standardized CB\u2010RBC production is reproducible. Moreover, extending CB\u2010RBC storage to 21\u2009days could maximize the inventory utility.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.70241","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T13:02:01Z","timestamp":1777467721000},"page":"1402-1414","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cord blood red cell concentrates for preterm neonate transfusion: Insights from the multicenter BORN trial"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1614-5576","authenticated-orcid":false,"given":"Claudio","family":"Pellegrino","sequence":"first","affiliation":[{"name":"Fondazione Policlinico A. Gemelli IRCCS  Rome Italy"},{"name":"Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Papacci","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico A. Gemelli IRCCS  Rome Italy"},{"name":"Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Dani","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliero Universitaria Careggi  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Cresi","sequence":"additional","affiliation":[{"name":"Citt\u00e0 della Salute e della Scienza  Torino Italy"},{"name":"Department of Public Health and Pediatrics Universit\u00e0 di Torino  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6235-4486","authenticated-orcid":false,"given":"Giulia","family":"Remaschi","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliero Universitaria Careggi  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Ansaldi","sequence":"additional","affiliation":[{"name":"Citt\u00e0 della Salute e della Scienza  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Giannantonio","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico A. Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Francesca","family":"Campagnoli","sequence":"additional","affiliation":[{"name":"Citt\u00e0 della Salute e della Scienza  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Vania","sequence":"additional","affiliation":[{"name":"Citt\u00e0 della Salute e della Scienza  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Fabbri","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliero Universitaria Pisana  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta Penta de Vera d'","family":"Aragona","sequence":"additional","affiliation":[{"name":"Ospedale Santobono Pausilipon  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Molisso","sequence":"additional","affiliation":[{"name":"Ospedale Evangelico Villa Betania  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Beccastrini","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliero Universitaria Careggi  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Dragonetti","sequence":"additional","affiliation":[{"name":"Citt\u00e0 della Salute e della Scienza  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Pasciuto","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico A. Gemelli IRCCS  Rome Italy"},{"name":"Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Gabbriellini","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliero Universitaria Pisana  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Baroni","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico A. Gemelli IRCCS  Rome Italy"},{"name":"Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7115-1469","authenticated-orcid":false,"given":"Francesca","family":"Serrao","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico A. Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Velia","family":"Purcaro","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico A. Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genny","family":"Raffaeli","sequence":"additional","affiliation":[{"name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico  Milan Italy"},{"name":"Department of Clinical Sciences and Community Health Universit\u00e0 di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Villa","sequence":"additional","affiliation":[{"name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2281-7498","authenticated-orcid":false,"given":"Daniele","family":"Prati","sequence":"additional","affiliation":[{"name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico  Milan Italy"},{"name":"Department of Clinical Sciences and Community Health Universit\u00e0 di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Mondello","sequence":"additional","affiliation":[{"name":"Grande Ospedale Metropolitano Bianchi Melacrino Morelli  Reggio Calabria Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Falcone","sequence":"additional","affiliation":[{"name":"Grande Ospedale Metropolitano Bianchi Melacrino Morelli  Reggio Calabria Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Letizia","family":"Patti","sequence":"additional","affiliation":[{"name":"Fondazione IRCCS Policlinico S. Matteo  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziana","family":"Boggini","sequence":"additional","affiliation":[{"name":"Fondazione IRCCS Policlinico S. Matteo  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Bergamaschi","sequence":"additional","affiliation":[{"name":"Fondazione IRCCS Policlinico S. Matteo  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iolanda","family":"Mozzetta","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico A. Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7022-5366","authenticated-orcid":false,"given":"Caterina Giovanna","family":"Valentini","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico A. Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Locatelli","sequence":"additional","affiliation":[{"name":"Citt\u00e0 della Salute e della Scienza  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Albiani","sequence":"additional","affiliation":[{"name":"Citt\u00e0 della Salute e della Scienza  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico Genzano","family":"Besso","sequence":"additional","affiliation":[{"name":"Citt\u00e0 della Salute e della Scienza  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia Vanina","family":"Cantone","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico A. Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Coscia","sequence":"additional","affiliation":[{"name":"Citt\u00e0 della Salute e della Scienza  Torino Italy"},{"name":"Department of Public Health and Pediatrics Universit\u00e0 di Torino  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Trimarchi","sequence":"additional","affiliation":[{"name":"Grande Ospedale Metropolitano Bianchi Melacrino Morelli  Reggio Calabria Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Capone","sequence":"additional","affiliation":[{"name":"Presidio Ospedaliero di Pescara  Pescara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Ghirardello","sequence":"additional","affiliation":[{"name":"Fondazione IRCCS Policlinico S. Matteo  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Vento","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico A. Gemelli IRCCS  Rome Italy"},{"name":"Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7214-1561","authenticated-orcid":false,"given":"Luciana","family":"Teofili","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico A. Gemelli IRCCS  Rome Italy"},{"name":"Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002042.pub6"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2025.14194"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2024-327926"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.18432"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-025-02079-4"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/sper.2002.37313"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.41643"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jped.2021.11.008"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000368296"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16851"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.16965"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-025-05797-0"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2025.103426"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-022-06949-8"},{"key":"e_1_2_9_16_1","volume-title":"Disposizioni relative ai requisiti di qualit\u00e0 e sicurezza del sangue e degli emocomponenti","author":"Ministero della Salute"},{"key":"e_1_2_9_17_1","volume-title":"Guide to the preparation, use and quality assurance of blood components","author":"European Directorate for the Quality of Medicines & HealthCare (EDQM)","year":"2020"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16918"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.2450\/2020.0169-20"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-025-02345-7"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-025-02519-3"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.70376"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/102809"},{"key":"e_1_2_9_24_1","first-page":"242","article-title":"Efficiency assessment of cord blood banking and compatibility with delayed cord clamping","volume":"23","author":"Manchanayake GS","year":"2025","journal-title":"Blood Transfus"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14574"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13424"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10561-016-9565-6"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2025-328598"},{"key":"e_1_2_9_29_1","volume-title":"Guideline: delayed umbilical cord clamping for improved maternal and infant health and nutrition outcomes","author":"World Health Organization","year":"2014"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000004167"},{"key":"e_1_2_9_31_1","unstructured":"National Institute of Care Excellence Guidelines. [Cited 2026 Mar 7]. Available from:https:\/\/www.nice.org.uk\/guidance\/qs105\/chapter\/Quality-statement-6-Delayed-cord-clamping"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare13202567"},{"issue":"3","key":"e_1_2_9_33_1","first-page":"484","article-title":"Recommendations for transfusion therapy in neonatology","volume":"13","author":"Girelli G","year":"2015","journal-title":"Blood Transfus"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.2450\/BloodTransfus.761"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2010.01440.x"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.70024"},{"issue":"10","key":"e_1_2_9_37_1","first-page":"441","article-title":"Clinical effects of leucoreduction of blood transfusions","volume":"69","author":"Bilgin YM","year":"2011","journal-title":"Neth J Med"},{"key":"e_1_2_9_38_1","volume-title":"Guide to the preparation, use and quality assurance of blood components","author":"European Directorate for the Quality of Medicines & HealthCare (EDQM)","year":"2025"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1246-7820(00)80013-0"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.70219"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01759"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2022.103402"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197402142900703"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16189"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17015"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12518"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2022.0152"},{"key":"#cr-split#-e_1_2_9_48_1.1","unstructured":"European Parliament and Council of the European Union. Regulation (EU) 2024\/1938 of the European Parliament and of the Council of 13 June 2024 on standards of quality and safety for substances of human origin intended for human application and repealing Directives 2002\/98\/EC and 2004\/23\/EC (Text with EEA relevance). Eur Union2024"},{"key":"#cr-split#-e_1_2_9_48_1.2","unstructured":"L 17.07.2024: 1\u201080 [cited 2026 Mar 7]. Available from:https:\/\/eur-lex.europa.eu\/eli\/reg\/2024\/1938\/oj\/eng"},{"key":"e_1_2_9_49_1","unstructured":"Euro GTP II. [Cited 2026 Mar 5]. Available from:https:\/\/tool.goodtissuepractices.site\/indexB.html"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.70241","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/trf.70241","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.70241","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T02:49:38Z","timestamp":1783651778000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.70241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,29]]},"references-count":49,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/trf.70241"],"URL":"https:\/\/doi.org\/10.1111\/trf.70241","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,29]]},"assertion":[{"value":"2026-03-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}