{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:31:08Z","timestamp":1792794668620,"version":"4.5.0"},"reference-count":67,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100024731","name":"AABB Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100024731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acquired hypofibrinogenemia poses significant bleeding risks. Concentrated sources of fibrinogen, whether cryoprecipitate or fibrinogen concentrates, are widely used. This scoping review aimed to identify and map the available evidence on fibrinogen supplementation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design and Methods<\/jats:title>\n                    <jats:p>We used the JBI Manual and PRISMA\u2010ScR guidelines. We included patients of all ages treated with fibrinogen supplementation. The concept was treatment with cryoprecipitate or fibrinogen concentrate (prophylactically or therapeutically); and context was any clinical setting worldwide. Eligible studies included randomized trials and observational studies with comparator arms. Comprehensive searches of three databases were performed on February 21, 2025. Primary studies meeting inclusion criteria were selected. UpSet data visualizations displayed studies with intersecting sets of characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From 8181 references screened, 134 met inclusion criteria, of which 61 were randomized trials and 16 propensity\u2010matched observational cohort studies. The highest proportion of trials focused on cardiovascular surgery (28\/61; 46%) then trauma (12\/61; 20%) populations and mainly assessed use of fibrinogen therapeutically (34\/61; 56%). More trials evaluated fibrinogen concentrate (53\/61; 87%) compared to cryoprecipitate (8\/61; 13%). Commonly reported outcomes included bleeding, transfusion needs, or mortality. Studies inconsistently reported dosing, timing, and definitions of hypofibrinogenemia. Studies evaluating certain key populations\u2014including obstetrics and pediatrics\u2014were limited. All but one propensity\u2010matched study was in either cardiovascular surgery or trauma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>There is a growing body of literature informing use of fibrinogen supplementation, particularly in cardiovascular surgery and trauma populations. Meta\u2010analyses appear feasible to inform evidence\u2010based guideline development; however, variability in dosing, timing, and definitions highlights the need for more harmonized research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.70255","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T06:51:03Z","timestamp":1779259863000},"page":"1424-1437","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The clinical use of cryoprecipitate and fibrinogen concentrate: A scoping review"],"prefix":"10.1111","volume":"66","author":[{"given":"Aaron S.","family":"Hess","sequence":"first","affiliation":[{"name":"New Zealand Blood Service  Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra K.","family":"White","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1910-2800","authenticated-orcid":false,"given":"Elizabeth P.","family":"Crowe","sequence":"additional","affiliation":[{"name":"Department of Pathology Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay S.","family":"Raval","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Vermont  Burlington Vermont USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3801-4198","authenticated-orcid":false,"given":"Jennifer","family":"Andrews","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Department of Pediatrics Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9847-0470","authenticated-orcid":false,"given":"Claudia S.","family":"Cohn","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5452-4529","authenticated-orcid":false,"given":"Mischa L.","family":"Covington","sequence":"additional","affiliation":[{"name":"Department of Pathology Mass General Brigham, Harvard University  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8042-1494","authenticated-orcid":false,"given":"Melissa M.","family":"Cushing","sequence":"additional","affiliation":[{"name":"Department of Pathology Weill Cornell Medicine, Cornell University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1281-0644","authenticated-orcid":false,"given":"Cyril","family":"Jacquot","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Children's National Hospital  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Virginia  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil K.","family":"Panigrahi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Perioperative and Pain Medicine Stanford University  Stanford California USA"},{"name":"Department of Pathology Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1646-9201","authenticated-orcid":false,"given":"Nabiha H.","family":"Saifee","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Washington  Seattle Washington USA"},{"name":"Department of Laboratory Medicine and Pathology Seattle Children's Hospital  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0517-3766","authenticated-orcid":false,"given":"Aaron A. 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