{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T18:43:37Z","timestamp":1786214617789,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2026,8]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Passenger lymphocyte syndrome (PLS) is a hematologic complication of ABO blood\u2010type minor incompatibility that can occur following both solid\u2010organ and hematopoietic stem cell transplant (HSCT). HSCT patients usually require red blood cell (RBC) transfusions until they achieve full erythroid engraftment. It is unclear whether the blood bank should honor the recipient's blood type or the donor's blood type at the time of issuing RBC products for minor ABO\u2010incompatible HSCT patients prior to full engraftment. To avoid this confusion, blood group O RBCs are often transfused. However, the role of this approach in the prevention of PLS in minor ABO\u2010mismatched HSCT recipients prior to full engraftment is not well understood.<\/jats:p>\n <\/jats:sec>\n \n Study Design and Methods<\/jats:title>\n We conducted a survey of academic hospital blood banks across the United States in October\u2013December 2025 to assess their practices for providing RBC transfusion support to minor\u2010incompatible HSCT patients.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Sixteen out of 24 hospital blood banks, including adult and pediatric centers, responded to the survey. The majority reported providing crossmatch\u2010compatible type O RBC to recipients with blood types A, B, or AB, regardless of engraftment outcome. Five do not routinely transfuse O RBC.<\/jats:p>\n Two hospitals had one patient each with PLS resulting in severe intravascular hemolysis, and 11 reported mild PLS despite providing crossmatch\u2010compatible type O RBC products to recipients.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Regardless of the blood type of the transfused RBC, mild PLS can occur in minor ABO\u2010incompatible HSCT patients prior to full engraftment.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/trf.70282","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T15:21:28Z","timestamp":1781796088000},"page":"1597-1601","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A survey of transfusion support strategies for passenger lymphocyte syndrome in minor\n ABO<\/scp>\n \u2010mismatched allogeneic hematopoietic stem cell transplantation"],"prefix":"10.1111","volume":"66","author":[{"given":"Ayda","family":"Javanbakht","sequence":"first","affiliation":[{"name":"Department of Pathology University of Texas Southwestern Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9480-2762","authenticated-orcid":false,"given":"Brian D.","family":"Adkins","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Texas Southwestern Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4199-5158","authenticated-orcid":false,"given":"Ravi","family":"Sarode","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Texas Southwestern Dallas Texas USA"},{"name":"Department of Internal Medicine University of Texas Southwestern Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2005.05.017"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2020.06.004"},{"key":"e_1_2_8_4_1","article-title":"Passenger lymphocyte syndrome and liver transplantation","volume":"2008","author":"Audet M","year":"2009","journal-title":"Clin Dev Immunol"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.22043"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198411013111807"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202306-1107OC"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1991.31191096190.x"},{"key":"e_1_2_8_9_1","first-page":"307","article-title":"Genetic testing to resolve the source of haemolytic antibody in solid organ 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