{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T06:46:44Z","timestamp":1782197204870,"version":"3.54.5"},"reference-count":69,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cold\u2010stored platelets (CSPs) are used in active bleeding due to their extended shelf life and preserved hemostatic function. Although both CSPs and cold\u2010stored whole blood (CS\u2010WB) are used clinically, the comparative effects of cold storage on their hemostatic and immunological properties remain partially understood. This study evaluated longitudinal changes in platelet function and immune markers stored at 4\u00b0C for 21\u2009days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design and Methods<\/jats:title>\n                    <jats:p>Eight healthy donors each provided an apheresis platelet (AP) unit in plasma and a whole blood (WB) unit, leukoreduced using a platelet\u2010sparing filter. Baseline samples were collected prior to cold\u2010storage and on days 2, 7, 14, and 21 of cold\u2010storage. Hemostatic, metabolic, and immunological parameters were assessed by aggregometry, clot retraction assays, and flow cytometry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At baseline, CD62P, Annexin V binding, CD47 expression, and aggregation amplitude did not differ significantly between products. CD154 was higher in apheresis platelets. Over 21\u2010day cold storage, CS\u2010WB exhibited a more pronounced decline in aggregation and metabolic functions. Expression of activation markers (CD62P, Annexin V) increased in both products, with a stronger rise in CS\u2010WB. CD47\n                      <jats:sup>+<\/jats:sup>\n                      platelets remained high in both products, whereas CD154\n                      <jats:sup>+<\/jats:sup>\n                      platelets transiently increased in CS\u2010WB but remained low in CSPs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Cold\u2010storage differentially affects platelet in vitro characteristics across product types. While CS\u2010WB exhibited greater functional and metabolic deterioration, both products retained viable platelet function through the end of 21\u2010day cold storage. Larger studies are required to determine whether the observed in vitro differences translate into clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.70284","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T05:52:16Z","timestamp":1782193936000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Distinct hemostatic and immune profiles of cold\u2010stored apheresis platelets compared to leukoreduced whole blood"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0462-2857","authenticated-orcid":false,"given":"Zohreh","family":"Tatari\u2010Calderone","sequence":"first","affiliation":[{"name":"Medical and Scientific Office American Red Cross Biomedical Services  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3906-3111","authenticated-orcid":false,"given":"Tamar P.","family":"Feldman","sequence":"additional","affiliation":[{"name":"Medical and Scientific Office American Red Cross Biomedical Services  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikechuku","family":"Aguilera\u2010Nwachuku","sequence":"additional","affiliation":[{"name":"1st Medical Brigade US Army  Killeen Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najib","family":"Adamu","sequence":"additional","affiliation":[{"name":"USN, Naval Medical Camp Lejeune  Jacksonville North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3513-5653","authenticated-orcid":false,"given":"Chet","family":"Voelker","sequence":"additional","affiliation":[{"name":"US Army, Institute of Surgical Research  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9958-9115","authenticated-orcid":false,"given":"M. Adam","family":"Meledeo","sequence":"additional","affiliation":[{"name":"US Army, Institute of Surgical Research  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8595-8856","authenticated-orcid":false,"given":"Bethany L.","family":"Brown","sequence":"additional","affiliation":[{"name":"Medical and Scientific Office American Red Cross Biomedical Services  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"issue":"2","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1093\/milmed\/usy120","article-title":"Whole blood transfusion","volume":"183","author":"Cap AP","year":"2018","journal-title":"Mil Med"},{"issue":"20","key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1182\/blood.2023022593","article-title":"Platelet dysfunction reversal with cold\u2010stored vs room temperature\u2010stored platelet transfusions","volume":"143","author":"Kogler VJ","year":"2024","journal-title":"Blood"},{"issue":"27","key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"24751","DOI":"10.1074\/jbc.M011642200","article-title":"Mechanisms of cold\u2010induced platelet actin assembly","volume":"276","author":"Hoffmeister KM","year":"2001","journal-title":"J Biol Chem"},{"issue":"2","key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1159\/000533735","article-title":"In vitro hemostatic functions of cold\u2010stored platelets","volume":"51","author":"Kirschall J","year":"2024","journal-title":"Transfus Med Hemother"},{"issue":"3","key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"e163","DOI":"10.1055\/s-0040-1714254","article-title":"The impact of cold storage on adenosine diphosphate\u2010mediated platelet responsiveness","volume":"4","author":"Koessler J","year":"2020","journal-title":"TH Open"},{"issue":"7","key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1111\/j.1537-2995.2012.03917.x","article-title":"Enhanced shear\u2010induced platelet aggregation due to low\u2010temperature storage","volume":"53","author":"Montgomery RK","year":"2013","journal-title":"Transfusion"},{"issue":"4","key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/j.jtha.2023.11.025","article-title":"Cold\u2010stored platelet hemostatic capacity is maintained for three weeks of storage and associated with taurine metabolism","volume":"22","author":"Shea SM","year":"2024","journal-title":"J Thromb Haemost"},{"issue":"1","key":"e_1_2_9_9_1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.transci.2018.12.011","article-title":"Physiology of cold\u2010stored platelets","volume":"58","author":"Getz TM","year":"2019","journal-title":"Transfus Apher Sci"},{"issue":"7","key":"e_1_2_9_10_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26072944","article-title":"Storage temperature affects platelet activation and degranulation in response to stimuli","volume":"26","author":"Winskel\u2010Wood B","year":"2025","journal-title":"Int J Mol Sci"},{"issue":"1","key":"e_1_2_9_11_1","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1097\/SHK.0000000000000082","article-title":"Hemostatic function of apheresis platelets stored at 4 degrees C and 22 degrees C","volume":"41","author":"Reddoch KM","year":"2014","journal-title":"Shock"},{"issue":"2","key":"e_1_2_9_12_1","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1097\/SLA.0000000000006317","article-title":"Early cold stored platelet transfusion following severe injury: a randomized clinical trial","volume":"280","author":"Sperry JL","year":"2024","journal-title":"Ann Surg"},{"issue":"1","key":"e_1_2_9_13_1","doi-asserted-by":"crossref","DOI":"10.1136\/tsaco-2023-001358","article-title":"Preferential whole blood transfusion during the early resuscitation period is associated with decreased mortality and transfusion requirements in traumatically injured patients","volume":"9","author":"Lammers D","year":"2024","journal-title":"Trauma Surg Acute Care Open"},{"issue":"4","key":"e_1_2_9_14_1","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1001\/jamasurg.2023.7178","article-title":"Timing to first whole blood transfusion and survival following severe hemorrhage in trauma patients","volume":"159","author":"Torres CM","year":"2024","journal-title":"JAMA Surg"},{"issue":"4","key":"e_1_2_9_15_1","first-page":"392","article-title":"Leukocyte reduction of cellular blood components. 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